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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
14
Cytoband
q22.3
Chromosome location (bp)
55027230 - 55049489
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Signal transduction inhibitor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Growth regulation, Ubl conjugation pathway
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q8WXH5 [Direct mapping] Suppressor of cytokine signaling 4
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Q5H9R6 [Target identity:100%; Query identity:100%] Full-length cDNA clone CS0DD006YF02 of Neuroblastoma of Homo sapiens (human); HCG1790822; Uncharacterized protein DKFZp686J1568
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0005515[protein binding] GO:0005942[phosphatidylinositol 3-kinase complex] GO:0007175[negative regulation of epidermal growth factor-activated receptor activity] GO:0009968[negative regulation of signal transduction] GO:0016567[protein ubiquitination] GO:0032436[positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0035556[intracellular signal transduction] GO:0046854[phosphatidylinositol phosphate biosynthetic process] GO:0046935[1-phosphatidylinositol-3-kinase regulator activity]
Q8WXH5 [Direct mapping] Suppressor of cytokine signaling 4
Show all
Q5H9R6 [Target identity:100%; Query identity:100%] Full-length cDNA clone CS0DD006YF02 of Neuroblastoma of Homo sapiens (human); HCG1790822; Uncharacterized protein DKFZp686J1568
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0005515[protein binding] GO:0005942[phosphatidylinositol 3-kinase complex] GO:0007175[negative regulation of epidermal growth factor-activated receptor activity] GO:0009968[negative regulation of signal transduction] GO:0016567[protein ubiquitination] GO:0032436[positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0035556[intracellular signal transduction] GO:0046854[phosphatidylinositol phosphate biosynthetic process] GO:0046935[1-phosphatidylinositol-3-kinase regulator activity]
Q8WXH5 [Direct mapping] Suppressor of cytokine signaling 4
Show all
Q5H9R6 [Target identity:100%; Query identity:100%] Full-length cDNA clone CS0DD006YF02 of Neuroblastoma of Homo sapiens (human); HCG1790822; Uncharacterized protein DKFZp686J1568
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0005515[protein binding] GO:0005942[phosphatidylinositol 3-kinase complex] GO:0007175[negative regulation of epidermal growth factor-activated receptor activity] GO:0009968[negative regulation of signal transduction] GO:0016567[protein ubiquitination] GO:0032436[positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0035556[intracellular signal transduction] GO:0046854[phosphatidylinositol phosphate biosynthetic process] GO:0046935[1-phosphatidylinositol-3-kinase regulator activity]
The Human Protein Atlas project is funded
