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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
8
Cytoband
q21.3
Chromosome location (bp)
90621995 - 90791632
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Positively regulates TNFSF11-induced osteoclast differentiation. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with SERCA2 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation. Negatively regulates osteoblast differentiation and positively regulates adipocyte differentiation via modulation of the canonical Wnt signaling pathway. Mediates the switch in lineage commitment to osteogenesis rather than to adipogenesis in mesenchymal stem cells by negatively regulating the expression, activity and nuclear localization of CTNNB1....show less
Gene summary (Entrez)i
Useful information about the gene from Entrez
Predicted to be involved in negative regulation of canonical Wnt signaling pathway; negative regulation of osteoblast differentiation; and positive regulation of fat cell differentiation. Predicted to act upstream of or within several processes, including positive regulation of bone resorption; positive regulation of osteoclast differentiation; and regulation of ATPase activity. Predicted to be located in endoplasmic reticulum. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
GO:0005783[endoplasmic reticulum] GO:0016020[membrane] GO:0045600[positive regulation of fat cell differentiation] GO:0045668[negative regulation of osteoblast differentiation] GO:0045672[positive regulation of osteoclast differentiation] GO:0045780[positive regulation of bone resorption] GO:0051480[regulation of cytosolic calcium ion concentration] GO:0090090[negative regulation of canonical Wnt signaling pathway]
GO:0005783[endoplasmic reticulum] GO:0016020[membrane] GO:0030316[osteoclast differentiation] GO:0043462[regulation of ATP-dependent activity] GO:0045600[positive regulation of fat cell differentiation] GO:0045668[negative regulation of osteoblast differentiation] GO:0045672[positive regulation of osteoclast differentiation] GO:0045780[positive regulation of bone resorption] GO:0051480[regulation of cytosolic calcium ion concentration] GO:0090090[negative regulation of canonical Wnt signaling pathway]
GO:0005783[endoplasmic reticulum] GO:0016020[membrane] GO:0045600[positive regulation of fat cell differentiation] GO:0045668[negative regulation of osteoblast differentiation] GO:0045672[positive regulation of osteoclast differentiation] GO:0045780[positive regulation of bone resorption] GO:0051480[regulation of cytosolic calcium ion concentration] GO:0090090[negative regulation of canonical Wnt signaling pathway]
The Human Protein Atlas project is funded
