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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
13
Cytoband
q34
Chromosome location (bp)
113820549 - 113864076
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Growth regulation, Host-virus interaction
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Calcium, Metal-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. [provided by RefSeq, Aug 2014]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q14393 [Direct mapping] Growth arrest-specific protein 6
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THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001764[neuron migration] GO:0001786[phosphatidylserine binding] GO:0001934[positive regulation of protein phosphorylation] GO:0001961[positive regulation of cytokine-mediated signaling pathway] GO:0003104[positive regulation of glomerular filtration] GO:0005102[signaling receptor binding] GO:0005509[calcium ion binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005788[endoplasmic reticulum lumen] GO:0005796[Golgi lumen] GO:0006468[protein phosphorylation] GO:0006909[phagocytosis] GO:0006915[apoptotic process] GO:0007165[signal transduction] GO:0007167[enzyme-linked receptor protein signaling pathway] GO:0007596[blood coagulation] GO:0009267[cellular response to starvation] GO:0010628[positive regulation of gene expression] GO:0010804[negative regulation of tumor necrosis factor-mediated signaling pathway] GO:0018105[peptidyl-serine phosphorylation] GO:0019064[fusion of virus membrane with host plasma membrane] GO:0019079[viral genome replication] GO:0030296[protein tyrosine kinase activator activity] GO:0030674[protein-macromolecule adaptor activity] GO:0030971[receptor tyrosine kinase binding] GO:0031093[platelet alpha granule lumen] GO:0031100[animal organ regeneration] GO:0031589[cell-substrate adhesion] GO:0032008[positive regulation of TOR signaling] GO:0032148[activation of protein kinase B activity] GO:0032689[negative regulation of interferon-gamma production] GO:0032692[negative regulation of interleukin-1 production] GO:0032715[negative regulation of interleukin-6 production] GO:0032720[negative regulation of tumor necrosis factor production] GO:0032825[positive regulation of natural killer cell differentiation] GO:0033028[myeloid cell apoptotic process] GO:0033033[negative regulation of myeloid cell apoptotic process] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0035457[cellular response to interferon-alpha] GO:0035754[B cell chemotaxis] GO:0043027[cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043277[apoptotic cell clearance] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0043491[protein kinase B signaling] GO:0044346[fibroblast apoptotic process] GO:0045860[positive regulation of protein kinase activity] GO:0045892[negative regulation of DNA-templated transcription] GO:0046718[viral entry into host cell] GO:0046813[receptor-mediated virion attachment to host cell] GO:0046827[positive regulation of protein export from nucleus] GO:0046872[metal ion binding] GO:0048018[receptor ligand activity] GO:0048146[positive regulation of fibroblast proliferation] GO:0050766[positive regulation of phagocytosis] GO:0050896[response to stimulus] GO:0051897[positive regulation of protein kinase B signaling] GO:0061098[positive regulation of protein tyrosine kinase activity] GO:0070062[extracellular exosome] GO:0070168[negative regulation of biomineral tissue development] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0070588[calcium ion transmembrane transport] GO:0071307[cellular response to vitamin K] GO:0071333[cellular response to glucose stimulus] GO:0071363[cellular response to growth factor stimulus] GO:0071466[cellular response to xenobiotic stimulus] GO:0072659[protein localization to plasma membrane] GO:0085029[extracellular matrix assembly] GO:0097028[dendritic cell differentiation] GO:0097241[hematopoietic stem cell migration to bone marrow] GO:1900142[negative regulation of oligodendrocyte apoptotic process] GO:2000270[negative regulation of fibroblast apoptotic process] GO:2000352[negative regulation of endothelial cell apoptotic process] GO:2000510[positive regulation of dendritic cell chemotaxis] GO:2000533[] GO:2000669[negative regulation of dendritic cell apoptotic process]
The Human Protein Atlas project is funded
