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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
BRF1 RNA polymerase III transcription initiation factor subunit
Protein classi
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
14
Cytoband
q32.33
Chromosome location (bp)
105209286 - 105315589
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is required for transcription of the U6 promoter....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes one of the three subunits of the RNA polymerase III transcription factor complex. This complex plays a central role in transcription initiation by RNA polymerase III on genes encoding tRNA, 5S rRNA, and other small structural RNAs. The gene product belongs to the TF2B family. Several alternatively spliced variants encoding different isoforms, that function at different promoters transcribed by RNA polymerase III, have been identified. [provided by RefSeq, Jun 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000126[transcription factor TFIIIB complex] GO:0000995[RNA polymerase III general transcription initiation factor activity] GO:0001006[RNA polymerase III type 3 promoter sequence-specific DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006352[DNA-templated transcription initiation] GO:0006383[transcription by RNA polymerase III] GO:0006384[transcription initiation at RNA polymerase III promoter] GO:0009303[rRNA transcription] GO:0009304[tRNA transcription] GO:0017025[TBP-class protein binding] GO:0046872[metal ion binding] GO:0070897[transcription preinitiation complex assembly] GO:0097550[transcription preinitiation complex]
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000126[transcription factor TFIIIB complex] GO:0000995[RNA polymerase III general transcription initiation factor activity] GO:0001006[RNA polymerase III type 3 promoter sequence-specific DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006352[DNA-templated transcription initiation] GO:0006383[transcription by RNA polymerase III] GO:0006384[transcription initiation at RNA polymerase III promoter] GO:0009303[rRNA transcription] GO:0009304[tRNA transcription] GO:0017025[TBP-class protein binding] GO:0046872[metal ion binding] GO:0070897[transcription preinitiation complex assembly] GO:0097550[transcription preinitiation complex]
A0A024R6P8 [Target identity:100%; Query identity:100%] BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae), isoform CRA_b
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Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000126[transcription factor TFIIIB complex] GO:0000995[RNA polymerase III general transcription initiation factor activity] GO:0001006[RNA polymerase III type 3 promoter sequence-specific DNA binding] GO:0003743[translation initiation factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006352[DNA-templated transcription initiation] GO:0006383[transcription by RNA polymerase III] GO:0006384[transcription initiation at RNA polymerase III promoter] GO:0006413[translational initiation] GO:0009303[rRNA transcription] GO:0009304[tRNA transcription] GO:0017025[TBP-class protein binding] GO:0046872[metal ion binding] GO:0070897[transcription preinitiation complex assembly] GO:0097550[transcription preinitiation complex]
SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000126[transcription factor TFIIIB complex] GO:0000995[RNA polymerase III general transcription initiation factor activity] GO:0001006[RNA polymerase III type 3 promoter sequence-specific DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006352[DNA-templated transcription initiation] GO:0006383[transcription by RNA polymerase III] GO:0006384[transcription initiation at RNA polymerase III promoter] GO:0009303[rRNA transcription] GO:0009304[tRNA transcription] GO:0017025[TBP-class protein binding] GO:0046872[metal ion binding] GO:0070897[transcription preinitiation complex assembly] GO:0097550[transcription preinitiation complex]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000126[transcription factor TFIIIB complex] GO:0000995[RNA polymerase III general transcription initiation factor activity] GO:0001006[RNA polymerase III type 3 promoter sequence-specific DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006352[DNA-templated transcription initiation] GO:0006383[transcription by RNA polymerase III] GO:0006384[transcription initiation at RNA polymerase III promoter] GO:0009303[rRNA transcription] GO:0009304[tRNA transcription] GO:0017025[TBP-class protein binding] GO:0046872[metal ion binding] GO:0070897[transcription preinitiation complex assembly] GO:0097550[transcription preinitiation complex]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000126[transcription factor TFIIIB complex] GO:0000995[RNA polymerase III general transcription initiation factor activity] GO:0006352[DNA-templated transcription initiation] GO:0006383[transcription by RNA polymerase III] GO:0017025[TBP-class protein binding] GO:0070897[transcription preinitiation complex assembly]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000126[transcription factor TFIIIB complex] GO:0000995[RNA polymerase III general transcription initiation factor activity] GO:0001006[RNA polymerase III type 3 promoter sequence-specific DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006352[DNA-templated transcription initiation] GO:0006383[transcription by RNA polymerase III] GO:0006384[transcription initiation at RNA polymerase III promoter] GO:0009303[rRNA transcription] GO:0009304[tRNA transcription] GO:0017025[TBP-class protein binding] GO:0045945[positive regulation of transcription by RNA polymerase III] GO:0046872[metal ion binding] GO:0070897[transcription preinitiation complex assembly] GO:0097550[transcription preinitiation complex]
V9HVY2 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein Li 76p
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000126[transcription factor TFIIIB complex] GO:0000995[RNA polymerase III general transcription initiation factor activity] GO:0001006[RNA polymerase III type 3 promoter sequence-specific DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006352[DNA-templated transcription initiation] GO:0006383[transcription by RNA polymerase III] GO:0006384[transcription initiation at RNA polymerase III promoter] GO:0009303[rRNA transcription] GO:0009304[tRNA transcription] GO:0017025[TBP-class protein binding] GO:0046872[metal ion binding] GO:0070897[transcription preinitiation complex assembly] GO:0097550[transcription preinitiation complex]
Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000126[transcription factor TFIIIB complex] GO:0000995[RNA polymerase III general transcription initiation factor activity] GO:0006352[DNA-templated transcription initiation] GO:0006383[transcription by RNA polymerase III] GO:0017025[TBP-class protein binding] GO:0070897[transcription preinitiation complex assembly]
Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Human disease related genes Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000126[transcription factor TFIIIB complex] GO:0000995[RNA polymerase III general transcription initiation factor activity] GO:0006352[DNA-templated transcription initiation] GO:0006383[transcription by RNA polymerase III] GO:0017025[TBP-class protein binding] GO:0070897[transcription preinitiation complex assembly]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000126[transcription factor TFIIIB complex] GO:0000995[RNA polymerase III general transcription initiation factor activity] GO:0006352[DNA-templated transcription initiation] GO:0006383[transcription by RNA polymerase III] GO:0017025[TBP-class protein binding] GO:0070897[transcription preinitiation complex assembly]
Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000126[transcription factor TFIIIB complex] GO:0000995[RNA polymerase III general transcription initiation factor activity] GO:0006352[DNA-templated transcription initiation] GO:0006383[transcription by RNA polymerase III] GO:0017025[TBP-class protein binding] GO:0070897[transcription preinitiation complex assembly]
Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000126[transcription factor TFIIIB complex] GO:0000995[RNA polymerase III general transcription initiation factor activity] GO:0006352[DNA-templated transcription initiation] GO:0006383[transcription by RNA polymerase III] GO:0017025[TBP-class protein binding] GO:0070897[transcription preinitiation complex assembly]
Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000126[transcription factor TFIIIB complex] GO:0000995[RNA polymerase III general transcription initiation factor activity] GO:0006352[DNA-templated transcription initiation] GO:0006383[transcription by RNA polymerase III] GO:0017025[TBP-class protein binding] GO:0070897[transcription preinitiation complex assembly]
The Human Protein Atlas project is funded
