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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
p32.3
Chromosome location (bp)
50437028 - 50960267
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Ubiquitin-binding protein 1. Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation 2. Potentiates but cannot initiate FAS-induced apoptosis (By similarity)....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Apoptosis
Gene summary (Entrez)i
Useful information about the gene from Entrez
Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005515[protein binding] GO:0005634[nucleus] GO:0005635[nuclear envelope] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0007253[cytoplasmic sequestering of NF-kappaB] GO:0008219[cell death] GO:0010942[positive regulation of cell death] GO:0019887[protein kinase regulator activity] GO:0019901[protein kinase binding] GO:0019904[protein domain specific binding] GO:0030155[regulation of cell adhesion] GO:0030433[ubiquitin-dependent ERAD pathway] GO:0031072[heat shock protein binding] GO:0031265[CD95 death-inducing signaling complex] GO:0031334[positive regulation of protein-containing complex assembly] GO:0031625[ubiquitin protein ligase binding] GO:0034098[VCP-NPL4-UFD1 AAA ATPase complex] GO:0042176[regulation of protein catabolic process] GO:0043065[positive regulation of apoptotic process] GO:0043130[ubiquitin binding] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0045732[positive regulation of protein catabolic process] GO:0045740[positive regulation of DNA replication] GO:0048471[perinuclear region of cytoplasm] GO:0051059[NF-kappaB binding] GO:1902043[positive regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1990917[ooplasm]
The Human Protein Atlas project is funded
