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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes Plasma proteins Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
5
Cytoband
q31.3
Chromosome location (bp)
140107777 - 140125619
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
This is a probable transcription activator that specifically binds the purine-rich single strand of the PUR element located upstream of the MYC gene. May play a role in the initiation of DNA replication and in recombination....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator, DNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q00577 [Direct mapping] Transcriptional activator protein Pur-alpha
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Yet undefined DNA-binding domains Cancer-related genes Candidate cancer biomarkers Disease related genes Human disease related genes Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000781[chromosome, telomeric region] GO:0000900[mRNA regulatory element binding translation repressor activity] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003690[double-stranded DNA binding] GO:0003691[double-stranded telomeric DNA binding] GO:0003697[single-stranded DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0003723[RNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0006268[DNA unwinding involved in DNA replication] GO:0006270[DNA replication initiation] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007399[nervous system development] GO:0008283[cell population proliferation] GO:0008284[positive regulation of cell population proliferation] GO:0017148[negative regulation of translation] GO:0030154[cell differentiation] GO:0030425[dendrite] GO:0032422[purine-rich negative regulatory element binding] GO:0032839[dendrite cytoplasm] GO:0042127[regulation of cell population proliferation] GO:0043025[neuronal cell body] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0045892[negative regulation of DNA-templated transcription] GO:0046332[SMAD binding] GO:0046651[lymphocyte proliferation] GO:0050673[epithelial cell proliferation] GO:0098794[postsynapse] GO:0098963[dendritic transport of messenger ribonucleoprotein complex] GO:0098978[glutamatergic synapse] GO:0140297[DNA-binding transcription factor binding] GO:0140416[transcription regulator inhibitor activity]
A0A494C0X8 [Direct mapping] Transcriptional activator protein Pur-alpha
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
A0A494C0H6 [Direct mapping] Transcriptional activator protein Pur-alpha
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
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GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0003677[DNA binding] GO:0003723[RNA binding] GO:0005634[nucleus] GO:0030154[cell differentiation] GO:0032422[purine-rich negative regulatory element binding] GO:0042127[regulation of cell population proliferation] GO:0045892[negative regulation of DNA-templated transcription]
Q00577 [Direct mapping] Transcriptional activator protein Pur-alpha
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Yet undefined DNA-binding domains Cancer-related genes Candidate cancer biomarkers Disease related genes Human disease related genes Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000781[chromosome, telomeric region] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003691[double-stranded telomeric DNA binding] GO:0003697[single-stranded DNA binding] GO:0003723[RNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0006268[DNA unwinding involved in DNA replication] GO:0006270[DNA replication initiation] GO:0006357[regulation of transcription by RNA polymerase II] GO:0017148[negative regulation of translation] GO:0030154[cell differentiation] GO:0032422[purine-rich negative regulatory element binding] GO:0032839[dendrite cytoplasm] GO:0042127[regulation of cell population proliferation] GO:0045892[negative regulation of DNA-templated transcription] GO:0140297[DNA-binding transcription factor binding]
The Human Protein Atlas project is funded
