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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
14
Cytoband
q24.1
Chromosome location (bp)
68787660 - 68796253
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis 1,2,3,4,5,6,7,8,9,10. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery 11. Functions by recruiting the CCR4-NOT deadenylase complex and components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes 12,13,14. Induces also the degradation of ARE-containing mRNAs even in absence of poly(A) tail (By similarity). Binds to 3'-UTR ARE of numerous mRNAs 15,16,17,18,19,20,21,22,23,24. Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Promotes ARE-mediated mRNA decay of mineralocorticoid receptor NR3C2 mRNA in response to hypertonic stress 25. Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA 26. Positively regulates monocyte/macrophage cell differentiation by promoting ARE-mediated mRNA decay of the cyclin-dependent kinase CDK6 mRNA 27. Promotes degradation of ARE-containing pluripotency-associated mRNAs in embryonic stem cells (ESCs), such as NANOG, through a fibroblast growth factor (FGF)-induced MAPK-dependent signaling pathway, and hence attenuates ESC self-renewal and positively regulates mesendoderm differentiation (By similarity). May play a role in mediating pro-apoptotic effects in malignant B-cells by promoting ARE-mediated mRNA decay of BCL2 mRNA 28. In association with ZFP36L2 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination and functional immune cell formation (By similarity). Together with ZFP36L2 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA (By similarity). Participates in the delivery of target ARE-mRNAs to processing bodies (PBs) 29. In addition to its cytosolic mRNA-decay function, plays a role in the regulation of nuclear mRNA 3'- end processing; modulates mRNA 3'-end maturation efficiency of the DLL4 mRNA through binding with an ARE embedded in a weak noncanonical polyadenylation (poly(A)) signal in endothelial cells 30. Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion 31. Plays a role in vasculogenesis and endocardial development (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis 32. Plays a role in myoblast cell differentiation (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
mRNA processing, mRNA transport, Transport
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene is a member of the TIS11 family of early response genes, which are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. This gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q07352 [Direct mapping] mRNA decay activator protein ZFP36L1
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A0A024R658 [Target identity:100%; Query identity:100%] mRNA decay activator protein ZFP36
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Mutational cancer driver genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000165[MAPK cascade] GO:0000932[P-body] GO:0003677[DNA binding] GO:0003723[RNA binding] GO:0003729[mRNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006397[mRNA processing] GO:0006417[regulation of translation] GO:0009611[response to wounding] GO:0010468[regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0010837[regulation of keratinocyte proliferation] GO:0014065[phosphatidylinositol 3-kinase signaling] GO:0031086[nuclear-transcribed mRNA catabolic process, deadenylation-independent decay] GO:0031440[regulation of mRNA 3'-end processing] GO:0032869[cellular response to insulin stimulus] GO:0033077[T cell differentiation in thymus] GO:0035925[mRNA 3'-UTR AU-rich region binding] GO:0038066[p38MAPK cascade] GO:0043488[regulation of mRNA stability] GO:0043491[protein kinase B signaling] GO:0044344[cellular response to fibroblast growth factor stimulus] GO:0045577[regulation of B cell differentiation] GO:0045600[positive regulation of fat cell differentiation] GO:0045616[regulation of keratinocyte differentiation] GO:0045647[negative regulation of erythrocyte differentiation] GO:0045657[positive regulation of monocyte differentiation] GO:0045661[regulation of myoblast differentiation] GO:0046872[metal ion binding] GO:0048382[mesendoderm development] GO:0051028[mRNA transport] GO:0061014[positive regulation of mRNA catabolic process] GO:0061158[3'-UTR-mediated mRNA destabilization] GO:0070371[ERK1 and ERK2 cascade] GO:0071320[cellular response to cAMP] GO:0071356[cellular response to tumor necrosis factor] GO:0071364[cellular response to epidermal growth factor stimulus] GO:0071375[cellular response to peptide hormone stimulus] GO:0071385[cellular response to glucocorticoid stimulus] GO:0071456[cellular response to hypoxia] GO:0071472[cellular response to salt stress] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0071889[14-3-3 protein binding] GO:0072091[regulation of stem cell proliferation] GO:0097403[cellular response to raffinose] GO:1900153[positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:1901991[negative regulation of mitotic cell cycle phase transition] GO:1902172[regulation of keratinocyte apoptotic process] GO:1904582[positive regulation of intracellular mRNA localization] GO:1990904[ribonucleoprotein complex]
Q07352 [Direct mapping] mRNA decay activator protein ZFP36L1
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A0A024R658 [Target identity:100%; Query identity:100%] mRNA decay activator protein ZFP36
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Mutational cancer driver genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000165[MAPK cascade] GO:0000288[nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:0000932[P-body] GO:0001570[vasculogenesis] GO:0003342[proepicardium development] GO:0003677[DNA binding] GO:0003723[RNA binding] GO:0003729[mRNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006397[mRNA processing] GO:0006402[mRNA catabolic process] GO:0006417[regulation of translation] GO:0006915[apoptotic process] GO:0007507[heart development] GO:0008283[cell population proliferation] GO:0009611[response to wounding] GO:0010468[regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0010837[regulation of keratinocyte proliferation] GO:0014065[phosphatidylinositol 3-kinase signaling] GO:0021915[neural tube development] GO:0031086[nuclear-transcribed mRNA catabolic process, deadenylation-independent decay] GO:0031440[regulation of mRNA 3'-end processing] GO:0032869[cellular response to insulin stimulus] GO:0033077[T cell differentiation in thymus] GO:0035264[multicellular organism growth] GO:0035925[mRNA 3'-UTR AU-rich region binding] GO:0038066[p38MAPK cascade] GO:0043488[regulation of mRNA stability] GO:0043491[protein kinase B signaling] GO:0044344[cellular response to fibroblast growth factor stimulus] GO:0045577[regulation of B cell differentiation] GO:0045600[positive regulation of fat cell differentiation] GO:0045616[regulation of keratinocyte differentiation] GO:0045647[negative regulation of erythrocyte differentiation] GO:0045657[positive regulation of monocyte differentiation] GO:0045661[regulation of myoblast differentiation] GO:0046872[metal ion binding] GO:0048382[mesendoderm development] GO:0048568[embryonic organ development] GO:0051028[mRNA transport] GO:0060710[chorio-allantoic fusion] GO:0060712[spongiotrophoblast layer development] GO:0061014[positive regulation of mRNA catabolic process] GO:0061158[3'-UTR-mediated mRNA destabilization] GO:0070371[ERK1 and ERK2 cascade] GO:0071320[cellular response to cAMP] GO:0071356[cellular response to tumor necrosis factor] GO:0071364[cellular response to epidermal growth factor stimulus] GO:0071375[cellular response to peptide hormone stimulus] GO:0071385[cellular response to glucocorticoid stimulus] GO:0071456[cellular response to hypoxia] GO:0071472[cellular response to salt stress] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0071889[14-3-3 protein binding] GO:0072091[regulation of stem cell proliferation] GO:0097403[cellular response to raffinose] GO:1900153[positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:1901991[negative regulation of mitotic cell cycle phase transition] GO:1902172[regulation of keratinocyte apoptotic process] GO:1904582[positive regulation of intracellular mRNA localization] GO:1990904[ribonucleoprotein complex]
G3V515 [Direct mapping] mRNA decay activator protein ZFP36
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014)
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GO:0003729[mRNA binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0035925[mRNA 3'-UTR AU-rich region binding] GO:0043488[regulation of mRNA stability] GO:0046872[metal ion binding] GO:0061158[3'-UTR-mediated mRNA destabilization] GO:1900153[positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:1990904[ribonucleoprotein complex]
G3V2D5 [Direct mapping] mRNA decay activator protein ZFP36
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014)
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GO:0003729[mRNA binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0006417[regulation of translation] GO:0010629[negative regulation of gene expression] GO:0035925[mRNA 3'-UTR AU-rich region binding] GO:0043488[regulation of mRNA stability] GO:0046872[metal ion binding] GO:0061014[positive regulation of mRNA catabolic process] GO:0061158[3'-UTR-mediated mRNA destabilization] GO:1900153[positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:1990904[ribonucleoprotein complex]
G3V2P5 [Direct mapping] mRNA decay activator protein ZFP36
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003729[mRNA binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0006417[regulation of translation] GO:0010629[negative regulation of gene expression] GO:0035925[mRNA 3'-UTR AU-rich region binding] GO:0043488[regulation of mRNA stability] GO:0046872[metal ion binding] GO:0061014[positive regulation of mRNA catabolic process] GO:0061158[3'-UTR-mediated mRNA destabilization] GO:1900153[positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:1990904[ribonucleoprotein complex]
The Human Protein Atlas project is funded
