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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
CD markers Plasma proteins Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
11
Cytoband
p15.5
Chromosome location (bp)
310041 - 315272
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) 1,2. Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV and SARS-CoV-2 S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration 3. Inhibits SARS-CoV-2 S protein-mediated syncytia formation 4. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation. In hepatocytes, IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation 5. IFITM2 and IFITM3 display anti-HCV activity that may complement the anti-HCV activity of IFITM1 by inhibiting the late stages of HCV entry, possibly in a coordinated manner by trapping the virion in the endosomal pathway and targeting it for degradation at the lysosome 6....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Interferon-induced transmembrane (IFITM) proteins are a family of interferon induced antiviral proteins. The family contains five members, including IFITM1, IFITM2 and IFITM3 that belong to the CD225 superfamily. The protein encoded by this gene restricts cellular entry by diverse viral pathogens, such as influenza A virus, Ebola virus and Sars-CoV-2. [provided by RefSeq, Nov 2021]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P13164 [Direct mapping] Interferon-induced transmembrane protein 1
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CD markers Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0001503[ossification] GO:0002376[immune system process] GO:0005515[protein binding] GO:0005764[lysosome] GO:0005765[lysosomal membrane] GO:0005886[plasma membrane] GO:0007166[cell surface receptor signaling pathway] GO:0008285[negative regulation of cell population proliferation] GO:0009615[response to virus] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0030336[negative regulation of cell migration] GO:0032991[protein-containing complex] GO:0034341[response to type II interferon] GO:0035455[response to interferon-alpha] GO:0035456[response to interferon-beta] GO:0045071[negative regulation of viral genome replication] GO:0045087[innate immune response] GO:0045669[positive regulation of osteoblast differentiation] GO:0046597[negative regulation of viral entry into host cell] GO:0051607[defense response to virus] GO:0060337[type I interferon signaling pathway]
P13164 [Direct mapping] Interferon-induced transmembrane protein 1
Show all
CD markers Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0001503[ossification] GO:0002376[immune system process] GO:0005515[protein binding] GO:0005764[lysosome] GO:0005765[lysosomal membrane] GO:0005886[plasma membrane] GO:0007166[cell surface receptor signaling pathway] GO:0008285[negative regulation of cell population proliferation] GO:0009615[response to virus] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0030336[negative regulation of cell migration] GO:0032991[protein-containing complex] GO:0034341[response to type II interferon] GO:0035455[response to interferon-alpha] GO:0035456[response to interferon-beta] GO:0045071[negative regulation of viral genome replication] GO:0045087[innate immune response] GO:0045669[positive regulation of osteoblast differentiation] GO:0046597[negative regulation of viral entry into host cell] GO:0051607[defense response to virus] GO:0060337[type I interferon signaling pathway]
P13164 [Direct mapping] Interferon-induced transmembrane protein 1
Show all
CD markers Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0001503[ossification] GO:0002376[immune system process] GO:0005515[protein binding] GO:0005764[lysosome] GO:0005765[lysosomal membrane] GO:0005886[plasma membrane] GO:0007166[cell surface receptor signaling pathway] GO:0008285[negative regulation of cell population proliferation] GO:0009615[response to virus] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0030336[negative regulation of cell migration] GO:0032991[protein-containing complex] GO:0034341[response to type II interferon] GO:0035455[response to interferon-alpha] GO:0035456[response to interferon-beta] GO:0045071[negative regulation of viral genome replication] GO:0045087[innate immune response] GO:0045669[positive regulation of osteoblast differentiation] GO:0046597[negative regulation of viral entry into host cell] GO:0051607[defense response to virus] GO:0060337[type I interferon signaling pathway]
P13164 [Direct mapping] Interferon-induced transmembrane protein 1
Show all
CD markers Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0001503[ossification] GO:0002376[immune system process] GO:0005515[protein binding] GO:0005764[lysosome] GO:0005765[lysosomal membrane] GO:0005886[plasma membrane] GO:0007166[cell surface receptor signaling pathway] GO:0008285[negative regulation of cell population proliferation] GO:0009615[response to virus] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0030336[negative regulation of cell migration] GO:0032991[protein-containing complex] GO:0034341[response to type II interferon] GO:0035455[response to interferon-alpha] GO:0035456[response to interferon-beta] GO:0045071[negative regulation of viral genome replication] GO:0045087[innate immune response] GO:0045669[positive regulation of osteoblast differentiation] GO:0046597[negative regulation of viral entry into host cell] GO:0051607[defense response to virus] GO:0060337[type I interferon signaling pathway]
The Human Protein Atlas project is funded
