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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Defective in cullin neddylation 1 domain containing 3
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
16
Cytoband
p12.3
Chromosome location (bp)
20854925 - 20900358
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes and may play a role in the cell cycle progression by regulating the SCF ubiquitin E3 ligase complex, after UV damage 1,2,3,4. At the cell membrane, can promote and as well inhibit cullins neddylation 5,6,7....show less
Gene summary (Entrez)i
Useful information about the gene from Entrez
Enables cullin family protein binding activity. Involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; regulation of protein neddylation; and response to UV-C. Located in nucleus; perinuclear region of cytoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000151[ubiquitin ligase complex] GO:0003674[molecular_function] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0010225[response to UV-C] GO:0010332[response to gamma radiation] GO:0010564[regulation of cell cycle process] GO:0016020[membrane] GO:0030308[negative regulation of cell growth] GO:0031624[ubiquitin conjugating enzyme binding] GO:0032182[ubiquitin-like protein binding] GO:0043065[positive regulation of apoptotic process] GO:0045116[protein neddylation] GO:0048471[perinuclear region of cytoplasm] GO:0051443[positive regulation of ubiquitin-protein transferase activity] GO:0097602[cullin family protein binding] GO:2000134[negative regulation of G1/S transition of mitotic cell cycle] GO:2000434[regulation of protein neddylation] GO:2000435[negative regulation of protein neddylation] GO:2000436[positive regulation of protein neddylation]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151[ubiquitin ligase complex] GO:0003674[molecular_function] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0010225[response to UV-C] GO:0010332[response to gamma radiation] GO:0010564[regulation of cell cycle process] GO:0016020[membrane] GO:0030308[negative regulation of cell growth] GO:0031624[ubiquitin conjugating enzyme binding] GO:0032182[ubiquitin-like protein binding] GO:0043065[positive regulation of apoptotic process] GO:0045116[protein neddylation] GO:0048471[perinuclear region of cytoplasm] GO:0051443[positive regulation of ubiquitin-protein transferase activity] GO:0097602[cullin family protein binding] GO:2000134[negative regulation of G1/S transition of mitotic cell cycle] GO:2000434[regulation of protein neddylation] GO:2000435[negative regulation of protein neddylation] GO:2000436[positive regulation of protein neddylation]
The Human Protein Atlas project is funded
