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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
FDA approved drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
9
Cytoband
q31.1
Chromosome location (bp)
101591604 - 101595021
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity....show less
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Calcium, Metal-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
Predicted to enable calcium ion binding activity and calcium-dependent protein serine/threonine phosphatase regulator activity. Predicted to be involved in regulation of catalytic activity. Predicted to act upstream of or within penetration of zona pellucida. Predicted to be located in sperm mitochondrial sheath. Predicted to be part of calcineurin complex. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q96LZ3 [Direct mapping] Calcineurin subunit B type 2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0005509[calcium ion binding] GO:0005515[protein binding] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0005955[calcineurin complex] GO:0006470[protein dephosphorylation] GO:0007341[penetration of zona pellucida] GO:0008287[protein serine/threonine phosphatase complex] GO:0008597[calcium-dependent protein serine/threonine phosphatase regulator activity] GO:0019902[phosphatase binding] GO:0036126[sperm flagellum] GO:0046872[metal ion binding] GO:0070886[positive regulation of calcineurin-NFAT signaling cascade] GO:0097225[sperm midpiece] GO:0097226[sperm mitochondrial sheath] GO:0097720[calcineurin-mediated signaling] GO:1901386[negative regulation of voltage-gated calcium channel activity] GO:1901387[positive regulation of voltage-gated calcium channel activity] GO:1905665[positive regulation of calcium ion import across plasma membrane] GO:1905949[negative regulation of calcium ion import across plasma membrane]
A0A1B0GUC7 [Direct mapping] Calcineurin subunit B type 2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC
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GO:0005509[calcium ion binding] GO:0005829[cytosol] GO:0008597[calcium-dependent protein serine/threonine phosphatase regulator activity] GO:0046872[metal ion binding]
The Human Protein Atlas project is funded
