GENERAL INFORMATIONi
Gene namei HMGB1
Synonyms DKFZp686A04236, HMG1, HMG3, SBP-1
Gene descriptioni High mobility group box 1
Protein classi Plasma proteins
Predicted locationi Secreted, Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 13
Cytoband q12.3
Chromosome location (bp) 30456704 - 30617597
Number of transcriptsi 6
Ensembl ENSG00000189403 (version 109)
Entrez gene 3146
HGNC HGNC:4983
UniProt P09429 (UniProt - Evidence at protein level)
neXtProt NX_P09429
GeneCards HMGB1
Antibodypedia HMGB1 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability 1. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury 2. Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors 3. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance 4, 5, 6, 7. Has proangiogdenic activity (By similarity). May be involved in platelet activation (By similarity). Binds to phosphatidylserine and phosphatidylethanolamide (By similarity). Bound to RAGE mediates signaling for neuronal outgrowth (By similarity). May play a role in accumulation of expanded polyglutamine (polyQ) proteins such as huntingtin (HTT) or TBP 8, 9. show less
Molecular function (UniProt)i DNA-binding
Biological process (UniProt)i Adaptive immunity, Autophagy, Chemotaxis, DNA damage, DNA recombination, DNA repair, Host-virus interaction, Immunity, Inflammatory response, Innate immunity
Gene summary (Entrez)i This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
HMGB1-201
ENSP00000369904
ENST00000326004
Q5T7C4
[Direct mapping] High mobility group protein B1
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002376 [immune system process]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005694 [chromosome]
GO:0045087 [innate immune response]
Show all
 158 aa
18.3 kDa 		No 0
HMGB1-202
ENSP00000343040
ENST00000339872
P09429
[Direct mapping] High mobility group protein B1
Show all
A0A024RDR0
[Target identity:100%; Query identity:100%] High mobility group protein B1
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000400 [four-way junction DNA binding]
GO:0000405 [bubble DNA binding]
GO:0000793 [condensed chromosome]
GO:0000976 [transcription cis-regulatory region binding]
GO:0001530 [lipopolysaccharide binding]
GO:0001773 [myeloid dendritic cell activation]
GO:0001786 [phosphatidylserine binding]
GO:0002218 [activation of innate immune response]
GO:0002250 [adaptive immune response]
GO:0002376 [immune system process]
GO:0002407 [dendritic cell chemotaxis]
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0002643 [regulation of tolerance induction]
GO:0002840 [regulation of T cell mediated immune response to tumor cell]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0003723 [RNA binding]
GO:0005125 [cytokine activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005886 [plasma membrane]
GO:0006265 [DNA topological change]
GO:0006281 [DNA repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006310 [DNA recombination]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006914 [autophagy]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007165 [signal transduction]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0008301 [DNA binding, bending]
GO:0009986 [cell surface]
GO:0010508 [positive regulation of autophagy]
GO:0016020 [membrane]
GO:0016829 [lyase activity]
GO:0017053 [transcription repressor complex]
GO:0017055 [negative regulation of RNA polymerase II transcription preinitiation complex assembly]
GO:0019958 [C-X-C chemokine binding]
GO:0031175 [neuron projection development]
GO:0031347 [regulation of defense response]
GO:0031507 [heterochromatin formation]
GO:0032072 [regulation of restriction endodeoxyribonuclease activity]
GO:0032103 [positive regulation of response to external stimulus]
GO:0032392 [DNA geometric change]
GO:0032425 [positive regulation of mismatch repair]
GO:0032689 [negative regulation of interferon-gamma production]
GO:0032732 [positive regulation of interleukin-1 production]
GO:0032733 [positive regulation of interleukin-10 production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0033151 [V(D)J recombination]
GO:0034165 [positive regulation of toll-like receptor 9 signaling pathway]
GO:0034774 [secretory granule lumen]
GO:0035711 [T-helper 1 cell activation]
GO:0035868 [alphav-beta3 integrin-HMGB1 complex]
GO:0042056 [chemoattractant activity]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0043065 [positive regulation of apoptotic process]
GO:0043277 [apoptotic cell clearance]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043371 [negative regulation of CD4-positive, alpha-beta T cell differentiation]
GO:0043388 [positive regulation of DNA binding]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0045063 [T-helper 1 cell differentiation]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046330 [positive regulation of JNK cascade]
GO:0046598 [positive regulation of viral entry into host cell]
GO:0050786 [RAGE receptor binding]
GO:0050918 [positive chemotaxis]
GO:0051106 [positive regulation of DNA ligation]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070182 [DNA polymerase binding]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0090026 [positive regulation of monocyte chemotaxis]
GO:0097100 [supercoiled DNA binding]
GO:0097350 [neutrophil clearance]
GO:0140297 [DNA-binding transcription factor binding]
GO:1904813 [ficolin-1-rich granule lumen]
GO:1905564 [positive regulation of vascular endothelial cell proliferation]
GO:2000343 [positive regulation of chemokine (C-X-C motif) ligand 2 production]
GO:2000426 [negative regulation of apoptotic cell clearance]
GO:2001200 [positive regulation of dendritic cell differentiation]
Show all
 215 aa
24.9 kDa 		No 0
HMGB1-203
ENSP00000345347
ENST00000341423
P09429
[Direct mapping] High mobility group protein B1
Show all
A0A024RDR0
[Target identity:100%; Query identity:100%] High mobility group protein B1
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000400 [four-way junction DNA binding]
GO:0000405 [bubble DNA binding]
GO:0000793 [condensed chromosome]
GO:0000976 [transcription cis-regulatory region binding]
GO:0001530 [lipopolysaccharide binding]
GO:0001773 [myeloid dendritic cell activation]
GO:0001786 [phosphatidylserine binding]
GO:0002218 [activation of innate immune response]
GO:0002250 [adaptive immune response]
GO:0002376 [immune system process]
GO:0002407 [dendritic cell chemotaxis]
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0002643 [regulation of tolerance induction]
GO:0002840 [regulation of T cell mediated immune response to tumor cell]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0003723 [RNA binding]
GO:0005125 [cytokine activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005886 [plasma membrane]
GO:0006265 [DNA topological change]
GO:0006281 [DNA repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006310 [DNA recombination]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006914 [autophagy]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007165 [signal transduction]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0008301 [DNA binding, bending]
GO:0009986 [cell surface]
GO:0010508 [positive regulation of autophagy]
GO:0016020 [membrane]
GO:0016829 [lyase activity]
GO:0017053 [transcription repressor complex]
GO:0017055 [negative regulation of RNA polymerase II transcription preinitiation complex assembly]
GO:0019958 [C-X-C chemokine binding]
GO:0031175 [neuron projection development]
GO:0031347 [regulation of defense response]
GO:0031507 [heterochromatin formation]
GO:0032072 [regulation of restriction endodeoxyribonuclease activity]
GO:0032103 [positive regulation of response to external stimulus]
GO:0032392 [DNA geometric change]
GO:0032425 [positive regulation of mismatch repair]
GO:0032689 [negative regulation of interferon-gamma production]
GO:0032732 [positive regulation of interleukin-1 production]
GO:0032733 [positive regulation of interleukin-10 production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0033151 [V(D)J recombination]
GO:0034165 [positive regulation of toll-like receptor 9 signaling pathway]
GO:0034774 [secretory granule lumen]
GO:0035711 [T-helper 1 cell activation]
GO:0035868 [alphav-beta3 integrin-HMGB1 complex]
GO:0042056 [chemoattractant activity]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0043065 [positive regulation of apoptotic process]
GO:0043277 [apoptotic cell clearance]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043371 [negative regulation of CD4-positive, alpha-beta T cell differentiation]
GO:0043388 [positive regulation of DNA binding]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0045063 [T-helper 1 cell differentiation]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046330 [positive regulation of JNK cascade]
GO:0046598 [positive regulation of viral entry into host cell]
GO:0050786 [RAGE receptor binding]
GO:0050918 [positive chemotaxis]
GO:0051106 [positive regulation of DNA ligation]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070182 [DNA polymerase binding]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0090026 [positive regulation of monocyte chemotaxis]
GO:0097100 [supercoiled DNA binding]
GO:0097350 [neutrophil clearance]
GO:0140297 [DNA-binding transcription factor binding]
GO:1904813 [ficolin-1-rich granule lumen]
GO:1905564 [positive regulation of vascular endothelial cell proliferation]
GO:2000343 [positive regulation of chemokine (C-X-C motif) ligand 2 production]
GO:2000426 [negative regulation of apoptotic cell clearance]
GO:2001200 [positive regulation of dendritic cell differentiation]
Show all
 215 aa
24.9 kDa 		No 0
HMGB1-204
ENSP00000382412
ENST00000399489
Q5T7C4
[Direct mapping] High mobility group protein B1
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002376 [immune system process]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005694 [chromosome]
GO:0045087 [innate immune response]
Show all
 158 aa
18.3 kDa 		No 0
HMGB1-205
ENSP00000382417
ENST00000399494
P09429
[Direct mapping] High mobility group protein B1
Show all
A0A024RDR0
[Target identity:100%; Query identity:100%] High mobility group protein B1
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000400 [four-way junction DNA binding]
GO:0000405 [bubble DNA binding]
GO:0000793 [condensed chromosome]
GO:0000976 [transcription cis-regulatory region binding]
GO:0001530 [lipopolysaccharide binding]
GO:0001773 [myeloid dendritic cell activation]
GO:0001786 [phosphatidylserine binding]
GO:0002218 [activation of innate immune response]
GO:0002250 [adaptive immune response]
GO:0002376 [immune system process]
GO:0002407 [dendritic cell chemotaxis]
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0002643 [regulation of tolerance induction]
GO:0002840 [regulation of T cell mediated immune response to tumor cell]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0003723 [RNA binding]
GO:0005125 [cytokine activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005886 [plasma membrane]
GO:0006265 [DNA topological change]
GO:0006281 [DNA repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006310 [DNA recombination]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006914 [autophagy]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007165 [signal transduction]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0008301 [DNA binding, bending]
GO:0009986 [cell surface]
GO:0010508 [positive regulation of autophagy]
GO:0016020 [membrane]
GO:0016829 [lyase activity]
GO:0017053 [transcription repressor complex]
GO:0017055 [negative regulation of RNA polymerase II transcription preinitiation complex assembly]
GO:0019958 [C-X-C chemokine binding]
GO:0031175 [neuron projection development]
GO:0031347 [regulation of defense response]
GO:0031507 [heterochromatin formation]
GO:0032072 [regulation of restriction endodeoxyribonuclease activity]
GO:0032103 [positive regulation of response to external stimulus]
GO:0032392 [DNA geometric change]
GO:0032425 [positive regulation of mismatch repair]
GO:0032689 [negative regulation of interferon-gamma production]
GO:0032732 [positive regulation of interleukin-1 production]
GO:0032733 [positive regulation of interleukin-10 production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0033151 [V(D)J recombination]
GO:0034165 [positive regulation of toll-like receptor 9 signaling pathway]
GO:0034774 [secretory granule lumen]
GO:0035711 [T-helper 1 cell activation]
GO:0035868 [alphav-beta3 integrin-HMGB1 complex]
GO:0042056 [chemoattractant activity]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0043065 [positive regulation of apoptotic process]
GO:0043277 [apoptotic cell clearance]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043371 [negative regulation of CD4-positive, alpha-beta T cell differentiation]
GO:0043388 [positive regulation of DNA binding]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0045063 [T-helper 1 cell differentiation]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046330 [positive regulation of JNK cascade]
GO:0046598 [positive regulation of viral entry into host cell]
GO:0050786 [RAGE receptor binding]
GO:0050918 [positive chemotaxis]
GO:0051106 [positive regulation of DNA ligation]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070182 [DNA polymerase binding]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0090026 [positive regulation of monocyte chemotaxis]
GO:0097100 [supercoiled DNA binding]
GO:0097350 [neutrophil clearance]
GO:0140297 [DNA-binding transcription factor binding]
GO:1904813 [ficolin-1-rich granule lumen]
GO:1905564 [positive regulation of vascular endothelial cell proliferation]
GO:2000343 [positive regulation of chemokine (C-X-C motif) ligand 2 production]
GO:2000426 [negative regulation of apoptotic cell clearance]
GO:2001200 [positive regulation of dendritic cell differentiation]
Show all
 215 aa
24.9 kDa 		No 0
HMGB1-206
ENSP00000384678
ENST00000405805
P09429
[Direct mapping] High mobility group protein B1
Show all
A0A024RDR0
[Target identity:100%; Query identity:100%] High mobility group protein B1
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000400 [four-way junction DNA binding]
GO:0000405 [bubble DNA binding]
GO:0000793 [condensed chromosome]
GO:0000976 [transcription cis-regulatory region binding]
GO:0001530 [lipopolysaccharide binding]
GO:0001773 [myeloid dendritic cell activation]
GO:0001786 [phosphatidylserine binding]
GO:0002218 [activation of innate immune response]
GO:0002250 [adaptive immune response]
GO:0002376 [immune system process]
GO:0002407 [dendritic cell chemotaxis]
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0002643 [regulation of tolerance induction]
GO:0002840 [regulation of T cell mediated immune response to tumor cell]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0003723 [RNA binding]
GO:0005125 [cytokine activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005886 [plasma membrane]
GO:0006265 [DNA topological change]
GO:0006281 [DNA repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006310 [DNA recombination]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006914 [autophagy]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007165 [signal transduction]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0008301 [DNA binding, bending]
GO:0009986 [cell surface]
GO:0010508 [positive regulation of autophagy]
GO:0016020 [membrane]
GO:0016829 [lyase activity]
GO:0017053 [transcription repressor complex]
GO:0017055 [negative regulation of RNA polymerase II transcription preinitiation complex assembly]
GO:0019958 [C-X-C chemokine binding]
GO:0031175 [neuron projection development]
GO:0031347 [regulation of defense response]
GO:0031507 [heterochromatin formation]
GO:0032072 [regulation of restriction endodeoxyribonuclease activity]
GO:0032103 [positive regulation of response to external stimulus]
GO:0032392 [DNA geometric change]
GO:0032425 [positive regulation of mismatch repair]
GO:0032689 [negative regulation of interferon-gamma production]
GO:0032732 [positive regulation of interleukin-1 production]
GO:0032733 [positive regulation of interleukin-10 production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0033151 [V(D)J recombination]
GO:0034165 [positive regulation of toll-like receptor 9 signaling pathway]
GO:0034774 [secretory granule lumen]
GO:0035711 [T-helper 1 cell activation]
GO:0035868 [alphav-beta3 integrin-HMGB1 complex]
GO:0042056 [chemoattractant activity]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0043065 [positive regulation of apoptotic process]
GO:0043277 [apoptotic cell clearance]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043371 [negative regulation of CD4-positive, alpha-beta T cell differentiation]
GO:0043388 [positive regulation of DNA binding]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0045063 [T-helper 1 cell differentiation]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046330 [positive regulation of JNK cascade]
GO:0046598 [positive regulation of viral entry into host cell]
GO:0050786 [RAGE receptor binding]
GO:0050918 [positive chemotaxis]
GO:0051106 [positive regulation of DNA ligation]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070182 [DNA polymerase binding]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0090026 [positive regulation of monocyte chemotaxis]
GO:0097100 [supercoiled DNA binding]
GO:0097350 [neutrophil clearance]
GO:0140297 [DNA-binding transcription factor binding]
GO:1904813 [ficolin-1-rich granule lumen]
GO:1905564 [positive regulation of vascular endothelial cell proliferation]
GO:2000343 [positive regulation of chemokine (C-X-C motif) ligand 2 production]
GO:2000426 [negative regulation of apoptotic cell clearance]
GO:2001200 [positive regulation of dendritic cell differentiation]
Show all
 215 aa
24.9 kDa 		No 0

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