GENERAL INFORMATIONi
Gene namei PPIA
Synonyms CYPA
Gene descriptioni Peptidylprolyl isomerase A
Protein classi Enzymes
FDA approved drug targets
Metabolic proteins
Plasma proteins
Predicted locationi Secreted, Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 7
Cytoband p13
Chromosome location (bp) 44796680 - 44824564
Number of transcriptsi 9
Ensembl ENSG00000196262 (version 109)
Entrez gene 5478
HGNC HGNC:9253
UniProt P62937 (UniProt - Evidence at protein level)
neXtProt NX_P62937
GeneCards PPIA
Antibodypedia PPIA antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides 1, 2, 3, 4, 5. Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation 6, 7. Activates endothelial cells (ECs) in a pro-inflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 8. Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis 9. In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 10. Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 11. Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates 12. Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans 13. Inhibits replication of influenza A virus (IAV) 14. Inhibits ITCH/AIP4-mediated ubiquitination of matrix protein 1 (M1) of IAV by impairing the interaction of ITCH/AIP4 with M1, followed by the suppression of the nuclear export of M1, and finally reduction of the replication of IAV 15, 16. show less
Molecular function (UniProt)i Isomerase, Rotamase
Biological process (UniProt)i Apoptosis, Host-virus interaction
Gene summary (Entrez)i This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
PPIA-201
ENSP00000430817
ENST00000355968
P62937
[Direct mapping] Peptidyl-prolyl cis-trans isomerase A Peptidyl-prolyl cis-trans isomerase A, N-terminally processed
Show all
Enzymes
   ENZYME proteins
   Isomerase
Metabolic proteins
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003723 [RNA binding]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006457 [protein folding]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006915 [apoptotic process]
GO:0016018 [cyclosporin A binding]
GO:0016020 [membrane]
GO:0016853 [isomerase activity]
GO:0019076 [viral release from host cell]
GO:0030168 [platelet activation]
GO:0030593 [neutrophil chemotaxis]
GO:0030595 [leukocyte chemotaxis]
GO:0031982 [vesicle]
GO:0032148 [activation of protein kinase B activity]
GO:0032873 [negative regulation of stress-activated MAPK cascade]
GO:0032991 [protein-containing complex]
GO:0034389 [lipid droplet organization]
GO:0034599 [cellular response to oxidative stress]
GO:0034774 [secretory granule lumen]
GO:0035307 [positive regulation of protein dephosphorylation]
GO:0042118 [endothelial cell activation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045069 [regulation of viral genome replication]
GO:0045070 [positive regulation of viral genome replication]
GO:0046790 [virion binding]
GO:0050714 [positive regulation of protein secretion]
GO:0051082 [unfolded protein binding]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0060352 [cell adhesion molecule production]
GO:0061944 [negative regulation of protein K48-linked ubiquitination]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
GO:1903901 [negative regulation of viral life cycle]
GO:1904399 [heparan sulfate binding]
GO:1904813 [ficolin-1-rich granule lumen]
GO:2001233 [regulation of apoptotic signaling pathway]
Show all
 105 aa
11.4 kDa 		No 0
PPIA-203
ENSP00000405975
ENST00000451562
C9J5S7
[Direct mapping] Peptidyl-prolyl cis-trans isomerase
Show all
Metabolic proteins
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0006457 [protein folding]
GO:0016853 [isomerase activity]
Show all
 121 aa
13.2 kDa 		No 0
PPIA-204
ENSP00000419425
ENST00000468812
P62937
[Direct mapping] Peptidyl-prolyl cis-trans isomerase A Peptidyl-prolyl cis-trans isomerase A, N-terminally processed
Show all
V9HWF5
[Target identity:100%; Query identity:100%] Peptidyl-prolyl cis-trans isomerase
Show all
Enzymes
   ENZYME proteins
   Isomerase
Metabolic proteins
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003723 [RNA binding]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006457 [protein folding]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006915 [apoptotic process]
GO:0016018 [cyclosporin A binding]
GO:0016020 [membrane]
GO:0016853 [isomerase activity]
GO:0019076 [viral release from host cell]
GO:0030168 [platelet activation]
GO:0030593 [neutrophil chemotaxis]
GO:0030595 [leukocyte chemotaxis]
GO:0031982 [vesicle]
GO:0032148 [activation of protein kinase B activity]
GO:0032873 [negative regulation of stress-activated MAPK cascade]
GO:0032991 [protein-containing complex]
GO:0034389 [lipid droplet organization]
GO:0034599 [cellular response to oxidative stress]
GO:0034774 [secretory granule lumen]
GO:0035307 [positive regulation of protein dephosphorylation]
GO:0042118 [endothelial cell activation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045069 [regulation of viral genome replication]
GO:0045070 [positive regulation of viral genome replication]
GO:0046790 [virion binding]
GO:0050714 [positive regulation of protein secretion]
GO:0051082 [unfolded protein binding]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0060352 [cell adhesion molecule production]
GO:0061944 [negative regulation of protein K48-linked ubiquitination]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
GO:1903901 [negative regulation of viral life cycle]
GO:1904399 [heparan sulfate binding]
GO:1904813 [ficolin-1-rich granule lumen]
GO:2001233 [regulation of apoptotic signaling pathway]
Show all
 165 aa
18 kDa 		No 0
PPIA-208
ENSP00000427976
ENST00000489459
P62937
[Direct mapping] Peptidyl-prolyl cis-trans isomerase A Peptidyl-prolyl cis-trans isomerase A, N-terminally processed
Show all
Enzymes
   ENZYME proteins
   Isomerase
Metabolic proteins
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003723 [RNA binding]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006457 [protein folding]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006915 [apoptotic process]
GO:0016018 [cyclosporin A binding]
GO:0016020 [membrane]
GO:0016853 [isomerase activity]
GO:0019076 [viral release from host cell]
GO:0030168 [platelet activation]
GO:0030593 [neutrophil chemotaxis]
GO:0030595 [leukocyte chemotaxis]
GO:0031982 [vesicle]
GO:0032148 [activation of protein kinase B activity]
GO:0032873 [negative regulation of stress-activated MAPK cascade]
GO:0032991 [protein-containing complex]
GO:0034389 [lipid droplet organization]
GO:0034599 [cellular response to oxidative stress]
GO:0034774 [secretory granule lumen]
GO:0035307 [positive regulation of protein dephosphorylation]
GO:0042118 [endothelial cell activation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045069 [regulation of viral genome replication]
GO:0045070 [positive regulation of viral genome replication]
GO:0046790 [virion binding]
GO:0050714 [positive regulation of protein secretion]
GO:0051082 [unfolded protein binding]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0060352 [cell adhesion molecule production]
GO:0061944 [negative regulation of protein K48-linked ubiquitination]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
GO:1903901 [negative regulation of viral life cycle]
GO:1904399 [heparan sulfate binding]
GO:1904813 [ficolin-1-rich granule lumen]
GO:2001233 [regulation of apoptotic signaling pathway]
Show all
 105 aa
11.4 kDa 		No 0
PPIA-210
ENSP00000479961
ENST00000620047
A0A7P0S768
[Direct mapping] Peptidyl-prolyl cis-trans isomerase A
Show all
Metabolic proteins
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
 61 aa
7.1 kDa 		No 0
PPIA-212
ENSP00000504216
ENST00000677022
P62937
[Direct mapping] Peptidyl-prolyl cis-trans isomerase A Peptidyl-prolyl cis-trans isomerase A, N-terminally processed
Show all
Enzymes
   ENZYME proteins
   Isomerase
Metabolic proteins
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003723 [RNA binding]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006457 [protein folding]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006915 [apoptotic process]
GO:0016018 [cyclosporin A binding]
GO:0016020 [membrane]
GO:0016853 [isomerase activity]
GO:0019076 [viral release from host cell]
GO:0030168 [platelet activation]
GO:0030593 [neutrophil chemotaxis]
GO:0030595 [leukocyte chemotaxis]
GO:0031982 [vesicle]
GO:0032148 [activation of protein kinase B activity]
GO:0032873 [negative regulation of stress-activated MAPK cascade]
GO:0032991 [protein-containing complex]
GO:0034389 [lipid droplet organization]
GO:0034599 [cellular response to oxidative stress]
GO:0034774 [secretory granule lumen]
GO:0035307 [positive regulation of protein dephosphorylation]
GO:0042118 [endothelial cell activation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045069 [regulation of viral genome replication]
GO:0045070 [positive regulation of viral genome replication]
GO:0046790 [virion binding]
GO:0050714 [positive regulation of protein secretion]
GO:0051082 [unfolded protein binding]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0060352 [cell adhesion molecule production]
GO:0061944 [negative regulation of protein K48-linked ubiquitination]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
GO:1903901 [negative regulation of viral life cycle]
GO:1904399 [heparan sulfate binding]
GO:1904813 [ficolin-1-rich granule lumen]
GO:2001233 [regulation of apoptotic signaling pathway]
Show all
 105 aa
11.4 kDa 		No 0
PPIA-213
ENSP00000504735
ENST00000677107
P62937
[Direct mapping] Peptidyl-prolyl cis-trans isomerase A Peptidyl-prolyl cis-trans isomerase A, N-terminally processed
Show all
Enzymes
   ENZYME proteins
   Isomerase
Metabolic proteins
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003723 [RNA binding]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006457 [protein folding]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006915 [apoptotic process]
GO:0016018 [cyclosporin A binding]
GO:0016020 [membrane]
GO:0016853 [isomerase activity]
GO:0019076 [viral release from host cell]
GO:0030168 [platelet activation]
GO:0030593 [neutrophil chemotaxis]
GO:0030595 [leukocyte chemotaxis]
GO:0031982 [vesicle]
GO:0032148 [activation of protein kinase B activity]
GO:0032873 [negative regulation of stress-activated MAPK cascade]
GO:0032991 [protein-containing complex]
GO:0034389 [lipid droplet organization]
GO:0034599 [cellular response to oxidative stress]
GO:0034774 [secretory granule lumen]
GO:0035307 [positive regulation of protein dephosphorylation]
GO:0042118 [endothelial cell activation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045069 [regulation of viral genome replication]
GO:0045070 [positive regulation of viral genome replication]
GO:0046790 [virion binding]
GO:0050714 [positive regulation of protein secretion]
GO:0051082 [unfolded protein binding]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0060352 [cell adhesion molecule production]
GO:0061944 [negative regulation of protein K48-linked ubiquitination]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
GO:1903901 [negative regulation of viral life cycle]
GO:1904399 [heparan sulfate binding]
GO:1904813 [ficolin-1-rich granule lumen]
GO:2001233 [regulation of apoptotic signaling pathway]
Show all
 105 aa
11.4 kDa 		No 0
PPIA-217
ENSP00000503804
ENST00000678789
P62937
[Direct mapping] Peptidyl-prolyl cis-trans isomerase A Peptidyl-prolyl cis-trans isomerase A, N-terminally processed
Show all
Enzymes
   ENZYME proteins
   Isomerase
Metabolic proteins
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003723 [RNA binding]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006457 [protein folding]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006915 [apoptotic process]
GO:0016018 [cyclosporin A binding]
GO:0016020 [membrane]
GO:0016853 [isomerase activity]
GO:0019076 [viral release from host cell]
GO:0030168 [platelet activation]
GO:0030593 [neutrophil chemotaxis]
GO:0030595 [leukocyte chemotaxis]
GO:0031982 [vesicle]
GO:0032148 [activation of protein kinase B activity]
GO:0032873 [negative regulation of stress-activated MAPK cascade]
GO:0032991 [protein-containing complex]
GO:0034389 [lipid droplet organization]
GO:0034599 [cellular response to oxidative stress]
GO:0034774 [secretory granule lumen]
GO:0035307 [positive regulation of protein dephosphorylation]
GO:0042118 [endothelial cell activation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045069 [regulation of viral genome replication]
GO:0045070 [positive regulation of viral genome replication]
GO:0046790 [virion binding]
GO:0050714 [positive regulation of protein secretion]
GO:0051082 [unfolded protein binding]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0060352 [cell adhesion molecule production]
GO:0061944 [negative regulation of protein K48-linked ubiquitination]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
GO:1903901 [negative regulation of viral life cycle]
GO:1904399 [heparan sulfate binding]
GO:1904813 [ficolin-1-rich granule lumen]
GO:2001233 [regulation of apoptotic signaling pathway]
Show all
 105 aa
11.4 kDa 		No 0
PPIA-218
ENSP00000502945
ENST00000678805
P62937
[Direct mapping] Peptidyl-prolyl cis-trans isomerase A Peptidyl-prolyl cis-trans isomerase A, N-terminally processed
Show all
Enzymes
   ENZYME proteins
   Isomerase
Metabolic proteins
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003723 [RNA binding]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006457 [protein folding]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006915 [apoptotic process]
GO:0016018 [cyclosporin A binding]
GO:0016020 [membrane]
GO:0016853 [isomerase activity]
GO:0019076 [viral release from host cell]
GO:0030168 [platelet activation]
GO:0030593 [neutrophil chemotaxis]
GO:0030595 [leukocyte chemotaxis]
GO:0031982 [vesicle]
GO:0032148 [activation of protein kinase B activity]
GO:0032873 [negative regulation of stress-activated MAPK cascade]
GO:0032991 [protein-containing complex]
GO:0034389 [lipid droplet organization]
GO:0034599 [cellular response to oxidative stress]
GO:0034774 [secretory granule lumen]
GO:0035307 [positive regulation of protein dephosphorylation]
GO:0042118 [endothelial cell activation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045069 [regulation of viral genome replication]
GO:0045070 [positive regulation of viral genome replication]
GO:0046790 [virion binding]
GO:0050714 [positive regulation of protein secretion]
GO:0051082 [unfolded protein binding]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0060352 [cell adhesion molecule production]
GO:0061944 [negative regulation of protein K48-linked ubiquitination]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
GO:1903901 [negative regulation of viral life cycle]
GO:1904399 [heparan sulfate binding]
GO:1904813 [ficolin-1-rich granule lumen]
GO:2001233 [regulation of apoptotic signaling pathway]
Show all
 105 aa
11.4 kDa 		No 0

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