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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
5
Cytoband
q35.3
Chromosome location (bp)
178204533 - 178211163
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
RNA-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001837[epithelial to mesenchymal transition] GO:0003676[nucleic acid binding] GO:0003723[RNA binding] GO:0003729[mRNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0010468[regulation of gene expression] GO:0010604[positive regulation of macromolecule metabolic process] GO:0016556[mRNA modification] GO:0045293[mRNA editing complex] GO:0045893[positive regulation of DNA-templated transcription] GO:0051173[positive regulation of nitrogen compound metabolic process] GO:0090575[RNA polymerase II transcription regulator complex] GO:0110165[cellular anatomical entity] GO:1901537[positive regulation of DNA demethylation] GO:1990904[ribonucleoprotein complex] GO:2000623[negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001837[epithelial to mesenchymal transition] GO:0003676[nucleic acid binding] GO:0003723[RNA binding] GO:0003729[mRNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0010468[regulation of gene expression] GO:0010604[positive regulation of macromolecule metabolic process] GO:0016556[mRNA modification] GO:0030425[dendrite] GO:0044877[protein-containing complex binding] GO:0045293[mRNA editing complex] GO:0045893[positive regulation of DNA-templated transcription] GO:0051173[positive regulation of nitrogen compound metabolic process] GO:0060341[regulation of cellular localization] GO:0071230[cellular response to amino acid stimulus] GO:0071598[neuronal ribonucleoprotein granule] GO:0090575[RNA polymerase II transcription regulator complex] GO:0110165[cellular anatomical entity] GO:1901537[positive regulation of DNA demethylation] GO:1904580[regulation of intracellular mRNA localization] GO:1990124[messenger ribonucleoprotein complex] GO:1990837[sequence-specific double-stranded DNA binding] GO:1990904[ribonucleoprotein complex] GO:2000623[negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0001837[epithelial to mesenchymal transition] GO:0003676[nucleic acid binding] GO:0003723[RNA binding] GO:0003729[mRNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0010468[regulation of gene expression] GO:0010604[positive regulation of macromolecule metabolic process] GO:0016556[mRNA modification] GO:0045293[mRNA editing complex] GO:0045893[positive regulation of DNA-templated transcription] GO:0051173[positive regulation of nitrogen compound metabolic process] GO:0090575[RNA polymerase II transcription regulator complex] GO:0110165[cellular anatomical entity] GO:1901537[positive regulation of DNA demethylation] GO:1990904[ribonucleoprotein complex] GO:2000623[negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001837[epithelial to mesenchymal transition] GO:0003676[nucleic acid binding] GO:0003723[RNA binding] GO:0003729[mRNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0010468[regulation of gene expression] GO:0010604[positive regulation of macromolecule metabolic process] GO:0016556[mRNA modification] GO:0045293[mRNA editing complex] GO:0045893[positive regulation of DNA-templated transcription] GO:0051173[positive regulation of nitrogen compound metabolic process] GO:0090575[RNA polymerase II transcription regulator complex] GO:0110165[cellular anatomical entity] GO:1901537[positive regulation of DNA demethylation] GO:1990904[ribonucleoprotein complex] GO:2000623[negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
The Human Protein Atlas project is funded
