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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
WW domain containing E3 ubiquitin protein ligase 2
Protein classi
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes Metabolic proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
16
Cytoband
q22.1
Chromosome location (bp)
69762328 - 69941741
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Transferase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Host-virus interaction, Ubl conjugation pathway
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination. The encoded protein contains four WW domains and may play a role in multiple processes including chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the tumor suppressor PTEN. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 10. [provided by RefSeq, Jul 2012]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Enzymes ENZYME proteins Transferases Metabolic proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000151[ubiquitin ligase complex] GO:0000209[protein polyubiquitination] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0006858[extracellular transport] GO:0008134[transcription factor binding] GO:0010629[negative regulation of gene expression] GO:0016020[membrane] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0032410[negative regulation of transporter activity] GO:0034765[regulation of ion transmembrane transport] GO:0036211[protein modification process] GO:0042391[regulation of membrane potential] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0045746[negative regulation of Notch signaling pathway] GO:0045892[negative regulation of DNA-templated transcription] GO:0046718[viral entry into host cell] GO:0051224[negative regulation of protein transport] GO:0051865[protein autoubiquitination] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0061630[ubiquitin protein ligase activity] GO:0070062[extracellular exosome] GO:0070534[protein K63-linked ubiquitination] GO:1901016[regulation of potassium ion transmembrane transporter activity]
Enzymes ENZYME proteins Transferases Metabolic proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000151[ubiquitin ligase complex] GO:0000209[protein polyubiquitination] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006366[transcription by RNA polymerase II] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0006858[extracellular transport] GO:0008134[transcription factor binding] GO:0010629[negative regulation of gene expression] GO:0016020[membrane] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0032410[negative regulation of transporter activity] GO:0034765[regulation of ion transmembrane transport] GO:0036211[protein modification process] GO:0042391[regulation of membrane potential] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0045746[negative regulation of Notch signaling pathway] GO:0045892[negative regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046718[viral entry into host cell] GO:0051224[negative regulation of protein transport] GO:0051865[protein autoubiquitination] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0061630[ubiquitin protein ligase activity] GO:0070062[extracellular exosome] GO:0070534[protein K63-linked ubiquitination] GO:1901016[regulation of potassium ion transmembrane transporter activity]
Enzymes ENZYME proteins Transferases Metabolic proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000151[ubiquitin ligase complex] GO:0000209[protein polyubiquitination] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0006858[extracellular transport] GO:0008134[transcription factor binding] GO:0010629[negative regulation of gene expression] GO:0016020[membrane] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0032410[negative regulation of transporter activity] GO:0034765[regulation of ion transmembrane transport] GO:0036211[protein modification process] GO:0042391[regulation of membrane potential] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0045746[negative regulation of Notch signaling pathway] GO:0045892[negative regulation of DNA-templated transcription] GO:0046718[viral entry into host cell] GO:0051224[negative regulation of protein transport] GO:0051865[protein autoubiquitination] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0061630[ubiquitin protein ligase activity] GO:0070062[extracellular exosome] GO:0070534[protein K63-linked ubiquitination] GO:1901016[regulation of potassium ion transmembrane transporter activity]
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000151[ubiquitin ligase complex] GO:0000209[protein polyubiquitination] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0006858[extracellular transport] GO:0008134[transcription factor binding] GO:0010629[negative regulation of gene expression] GO:0016020[membrane] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0032410[negative regulation of transporter activity] GO:0034765[regulation of ion transmembrane transport] GO:0036211[protein modification process] GO:0042391[regulation of membrane potential] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0045746[negative regulation of Notch signaling pathway] GO:0045892[negative regulation of DNA-templated transcription] GO:0046718[viral entry into host cell] GO:0051224[negative regulation of protein transport] GO:0051865[protein autoubiquitination] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0061630[ubiquitin protein ligase activity] GO:0070062[extracellular exosome] GO:0070534[protein K63-linked ubiquitination] GO:1901016[regulation of potassium ion transmembrane transporter activity]
The Human Protein Atlas project is funded
