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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
10
Cytoband
q11.21
Chromosome location (bp)
43194535 - 43267065
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, KRAS, HRAS, and NRAS (in vitro). Plays a role in cell migration....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Guanine-nucleotide releasing factor
Gene summary (Entrez)i
Useful information about the gene from Entrez
Enables guanyl-nucleotide exchange factor activity. Involved in cell migration and positive regulation of Ras protein signal transduction. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q8N9B8 [Direct mapping] Ras-GEF domain-containing family member 1A
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007264[small GTPase mediated signal transduction] GO:0007265[Ras protein signal transduction] GO:0016477[cell migration] GO:0043547[positive regulation of GTPase activity] GO:0046579[positive regulation of Ras protein signal transduction]
Q8N9B8 [Direct mapping] Ras-GEF domain-containing family member 1A
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007264[small GTPase mediated signal transduction] GO:0007265[Ras protein signal transduction] GO:0016477[cell migration] GO:0043547[positive regulation of GTPase activity] GO:0046579[positive regulation of Ras protein signal transduction]
Q8N9B8 [Direct mapping] Ras-GEF domain-containing family member 1A
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007264[small GTPase mediated signal transduction] GO:0007265[Ras protein signal transduction] GO:0016477[cell migration] GO:0043547[positive regulation of GTPase activity] GO:0046579[positive regulation of Ras protein signal transduction]
The Human Protein Atlas project is funded
