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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Transporter 2, ATP binding cassette subfamily B member
Protein classi
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Enzymes Human disease related genes Potential drug targets Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
6
Cytoband
p21.32
Chromosome location (bp)
32821833 - 32838739
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
ABC transporter associated with antigen processing. In complex with TAP1 mediates unidirectional translocation of peptide antigens from cytosol to endoplasmic reticulum (ER) for loading onto MHC class I (MHCI) molecules 1,2. Uses the chemical energy of ATP to export peptides against the concentration gradient 3. During the transport cycle alternates between 'inward-facing' state with peptide binding site facing the cytosol to 'outward-facing' state with peptide binding site facing the ER lumen. Peptide antigen binding to ATP-loaded TAP1-TAP2 induces a switch to hydrolysis-competent 'outward-facing' conformation ready for peptide loading onto nascent MHCI molecules. Subsequently ATP hydrolysis resets the transporter to the 'inward facing' state for a new cycle 4,5,6. Typically transports intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via IFNG-induced immunoproteasome. Binds peptides with free N- and C-termini, the first three and the C-terminal residues being critical. Preferentially selects peptides having a highly hydrophobic residue at position 3 and hydrophobic or charged residues at the C-terminal anchor. Proline at position 2 has the most destabilizing effect 7,8,9. As a component of the peptide loading complex (PLC), acts as a molecular scaffold essential for peptide-MHCI assembly and antigen presentation 10,11,12....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Translocase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Adaptive immunity, Host-virus interaction, Immunity, Peptide transport, Protein transport, Transport
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. [provided by RefSeq, Feb 2014]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q5JNW1 [Target identity:100%; Query identity:100%] TAP2; Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP); Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP), isoform CRA_b; cDNA FLJ77215, highly similar to Homo sapiens transporter 2, ATP-binding cassette, sub-family B (MDR/TAP), mRNA
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Enzymes ENZYME proteins Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Disease related genes Potential drug targets Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0001913[T cell mediated cytotoxicity] GO:0001916[positive regulation of T cell mediated cytotoxicity] GO:0002237[response to molecule of bacterial origin] GO:0002250[adaptive immune response] GO:0002376[immune system process] GO:0002481[antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent] GO:0002485[antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent] GO:0002489[antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0015031[protein transport] GO:0015433[ABC-type peptide antigen transporter activity] GO:0015440[ABC-type peptide transporter activity] GO:0015833[peptide transport] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016607[nuclear speck] GO:0016887[ATP hydrolysis activity] GO:0019885[antigen processing and presentation of endogenous peptide antigen via MHC class I] GO:0023029[MHC class Ib protein binding] GO:0030176[integral component of endoplasmic reticulum membrane] GO:0030670[phagocytic vesicle membrane] GO:0033116[endoplasmic reticulum-Golgi intermediate compartment membrane] GO:0042287[MHC protein binding] GO:0042288[MHC class I protein binding] GO:0042605[peptide antigen binding] GO:0042626[ATPase-coupled transmembrane transporter activity] GO:0042824[MHC class I peptide loading complex] GO:0042825[TAP complex] GO:0046872[metal ion binding] GO:0046967[cytosol to endoplasmic reticulum transport] GO:0046968[peptide antigen transport] GO:0046978[TAP1 binding] GO:0046980[tapasin binding] GO:0055085[transmembrane transport] GO:0140359[ABC-type transporter activity] GO:1904680[peptide transmembrane transporter activity]
The Human Protein Atlas project is funded
