We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
11
Cytoband
q22.3
Chromosome location (bp)
105041326 - 105101431
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Protease inhibitor, Thiol protease inhibitor
Gene summary (Entrez)i
Useful information about the gene from Entrez
Enables several functions, including CARD domain binding activity; cysteine-type endopeptidase inhibitor activity; and enzyme binding activity. Involved in several processes, including negative regulation of cysteine-type endopeptidase activity; regulation of gene expression; and regulation of signal transduction. Part of protease inhibitor complex. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q5EG05 [Direct mapping] Caspase recruitment domain-containing protein 16
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197[cysteine-type endopeptidase activity] GO:0004869[cysteine-type endopeptidase inhibitor activity] GO:0005515[protein binding] GO:0006508[proteolysis] GO:0010466[negative regulation of peptidase activity] GO:0010804[negative regulation of tumor necrosis factor-mediated signaling pathway] GO:0019900[kinase binding] GO:0030414[peptidase inhibitor activity] GO:0031665[negative regulation of lipopolysaccharide-mediated signaling pathway] GO:0032091[negative regulation of protein binding] GO:0032691[negative regulation of interleukin-1 beta production] GO:0032991[protein-containing complex] GO:0042802[identical protein binding] GO:0042981[regulation of apoptotic process] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0050700[CARD domain binding] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0071222[cellular response to lipopolysaccharide] GO:0071456[cellular response to hypoxia] GO:0071494[cellular response to UV-C] GO:0089720[caspase binding] GO:0097179[protease inhibitor complex] GO:0097340[inhibition of cysteine-type endopeptidase activity]
Q5EG05 [Direct mapping] Caspase recruitment domain-containing protein 16
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197[cysteine-type endopeptidase activity] GO:0004869[cysteine-type endopeptidase inhibitor activity] GO:0005515[protein binding] GO:0006508[proteolysis] GO:0010466[negative regulation of peptidase activity] GO:0010804[negative regulation of tumor necrosis factor-mediated signaling pathway] GO:0019900[kinase binding] GO:0030414[peptidase inhibitor activity] GO:0031665[negative regulation of lipopolysaccharide-mediated signaling pathway] GO:0032091[negative regulation of protein binding] GO:0032691[negative regulation of interleukin-1 beta production] GO:0032991[protein-containing complex] GO:0042802[identical protein binding] GO:0042981[regulation of apoptotic process] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0050700[CARD domain binding] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0071222[cellular response to lipopolysaccharide] GO:0071456[cellular response to hypoxia] GO:0071494[cellular response to UV-C] GO:0089720[caspase binding] GO:0097179[protease inhibitor complex] GO:0097340[inhibition of cysteine-type endopeptidase activity]
The Human Protein Atlas project is funded
