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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
6
Cytoband
p21.33
Chromosome location (bp)
31665227 - 31670343
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine 1,2. Participates in Wnt signaling (By similarity)....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Wnt signaling pathway
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P67870 [Direct mapping] Casein kinase II subunit beta
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N0E4C7 [Target identity:100%; Query identity:100%] Casein kinase II subunit beta
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0003682[chromatin binding] GO:0004674[protein serine/threonine kinase activity] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005956[protein kinase CK2 complex] GO:0006468[protein phosphorylation] GO:0007165[signal transduction] GO:0008285[negative regulation of cell population proliferation] GO:0010862[positive regulation of pathway-restricted SMAD protein phosphorylation] GO:0016055[Wnt signaling pathway] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0019887[protein kinase regulator activity] GO:0019904[protein domain specific binding] GO:0031519[PcG protein complex] GO:0032927[positive regulation of activin receptor signaling pathway] GO:0033211[adiponectin-activated signaling pathway] GO:0034774[secretory granule lumen] GO:0042802[identical protein binding] GO:0043537[negative regulation of blood vessel endothelial cell migration] GO:0046872[metal ion binding] GO:0051101[regulation of DNA binding] GO:0061154[endothelial tube morphogenesis] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0065003[protein-containing complex assembly] GO:0070062[extracellular exosome] GO:0080163[regulation of protein serine/threonine phosphatase activity] GO:1904813[ficolin-1-rich granule lumen]
P67870 [Direct mapping] Casein kinase II subunit beta
Show all
N0E4C7 [Target identity:100%; Query identity:100%] Casein kinase II subunit beta
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0003682[chromatin binding] GO:0004674[protein serine/threonine kinase activity] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005956[protein kinase CK2 complex] GO:0006468[protein phosphorylation] GO:0007165[signal transduction] GO:0008285[negative regulation of cell population proliferation] GO:0010862[positive regulation of pathway-restricted SMAD protein phosphorylation] GO:0016055[Wnt signaling pathway] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0019887[protein kinase regulator activity] GO:0019904[protein domain specific binding] GO:0031519[PcG protein complex] GO:0032927[positive regulation of activin receptor signaling pathway] GO:0033211[adiponectin-activated signaling pathway] GO:0034774[secretory granule lumen] GO:0042802[identical protein binding] GO:0043537[negative regulation of blood vessel endothelial cell migration] GO:0046872[metal ion binding] GO:0051101[regulation of DNA binding] GO:0061154[endothelial tube morphogenesis] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0065003[protein-containing complex assembly] GO:0070062[extracellular exosome] GO:0080163[regulation of protein serine/threonine phosphatase activity] GO:1904813[ficolin-1-rich granule lumen]
P67870 [Direct mapping] Casein kinase II subunit beta
Show all
N0E4C7 [Target identity:100%; Query identity:100%] Casein kinase II subunit beta
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0003682[chromatin binding] GO:0004674[protein serine/threonine kinase activity] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005956[protein kinase CK2 complex] GO:0006468[protein phosphorylation] GO:0007165[signal transduction] GO:0008285[negative regulation of cell population proliferation] GO:0010862[positive regulation of pathway-restricted SMAD protein phosphorylation] GO:0016055[Wnt signaling pathway] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0019887[protein kinase regulator activity] GO:0019904[protein domain specific binding] GO:0031519[PcG protein complex] GO:0032927[positive regulation of activin receptor signaling pathway] GO:0033211[adiponectin-activated signaling pathway] GO:0034774[secretory granule lumen] GO:0042802[identical protein binding] GO:0043537[negative regulation of blood vessel endothelial cell migration] GO:0046872[metal ion binding] GO:0051101[regulation of DNA binding] GO:0061154[endothelial tube morphogenesis] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0065003[protein-containing complex assembly] GO:0070062[extracellular exosome] GO:0080163[regulation of protein serine/threonine phosphatase activity] GO:1904813[ficolin-1-rich granule lumen]
The Human Protein Atlas project is funded
