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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
12
Cytoband
p13.31
Chromosome location (bp)
6965327 - 6970780
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Receptor, Repressor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Enables several functions, including protein C-terminus binding activity; protein N-terminus binding activity; and protein dimerization activity. Involved in several processes, including defense response to virus; positive regulation of cell cycle phase transition; and regulation of transcription, DNA-templated. Located in several cellular components, including cell surface; mitochondrial membrane; and nuclear matrix. Part of mitochondrial prohibitin complex. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
MEMSAT3 predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
MEMSAT3 predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000423[mitophagy] GO:0002639[positive regulation of immunoglobulin production] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005743[mitochondrial inner membrane] GO:0005886[plasma membrane] GO:0006606[protein import into nucleus] GO:0007005[mitochondrion organization] GO:0007062[sister chromatid cohesion] GO:0007202[activation of phospholipase C activity] GO:0008022[protein C-terminus binding] GO:0009986[cell surface] GO:0016020[membrane] GO:0016363[nuclear matrix] GO:0016477[cell migration] GO:0023035[CD40 signaling pathway] GO:0030331[nuclear estrogen receptor binding] GO:0031536[positive regulation of exit from mitosis] GO:0032991[protein-containing complex] GO:0033218[amide binding] GO:0035632[mitochondrial prohibitin complex] GO:0039529[RIG-I signaling pathway] GO:0042113[B cell activation] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043066[negative regulation of apoptotic process] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0045892[negative regulation of DNA-templated transcription] GO:0046625[sphingolipid binding] GO:0046982[protein heterodimerization activity] GO:0047485[protein N-terminus binding] GO:0050821[protein stabilization] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0071944[cell periphery] GO:0140374[antiviral innate immune response] GO:1900208[regulation of cardiolipin metabolic process] GO:1901224[positive regulation of NIK/NF-kappaB signaling] GO:1902808[positive regulation of cell cycle G1/S phase transition] GO:1904959[regulation of cytochrome-c oxidase activity] GO:1990051[activation of protein kinase C activity]
MEMSAT3 predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000423[mitophagy] GO:0002639[positive regulation of immunoglobulin production] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005743[mitochondrial inner membrane] GO:0005886[plasma membrane] GO:0006606[protein import into nucleus] GO:0007005[mitochondrion organization] GO:0007062[sister chromatid cohesion] GO:0007202[activation of phospholipase C activity] GO:0008022[protein C-terminus binding] GO:0009611[response to wounding] GO:0009986[cell surface] GO:0014069[postsynaptic density] GO:0016020[membrane] GO:0016363[nuclear matrix] GO:0016477[cell migration] GO:0023035[CD40 signaling pathway] GO:0030331[nuclear estrogen receptor binding] GO:0030424[axon] GO:0030520[intracellular estrogen receptor signaling pathway] GO:0031536[positive regulation of exit from mitosis] GO:0032991[protein-containing complex] GO:0033147[negative regulation of intracellular estrogen receptor signaling pathway] GO:0033218[amide binding] GO:0033598[mammary gland epithelial cell proliferation] GO:0033600[negative regulation of mammary gland epithelial cell proliferation] GO:0035632[mitochondrial prohibitin complex] GO:0039529[RIG-I signaling pathway] GO:0042113[B cell activation] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043066[negative regulation of apoptotic process] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0045892[negative regulation of DNA-templated transcription] GO:0046625[sphingolipid binding] GO:0046982[protein heterodimerization activity] GO:0047485[protein N-terminus binding] GO:0048786[presynaptic active zone] GO:0050821[protein stabilization] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0060744[mammary gland branching involved in thelarche] GO:0060749[mammary gland alveolus development] GO:0060762[regulation of branching involved in mammary gland duct morphogenesis] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0071300[cellular response to retinoic acid] GO:0071456[cellular response to hypoxia] GO:0071944[cell periphery] GO:0098800[inner mitochondrial membrane protein complex] GO:0098978[glutamatergic synapse] GO:0098982[GABA-ergic synapse] GO:0140374[antiviral innate immune response] GO:1900208[regulation of cardiolipin metabolic process] GO:1901224[positive regulation of NIK/NF-kappaB signaling] GO:1902808[positive regulation of cell cycle G1/S phase transition] GO:1904959[regulation of cytochrome-c oxidase activity] GO:1990051[activation of protein kinase C activity]
MEMSAT3 predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
MEMSAT3 predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
