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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes FDA approved drug targets Human disease related genes Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
p13.1
Chromosome location (bp)
8159149 - 8163546
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity). Major SNARE protein of synaptic vesicles which mediates fusion of synaptic vesicles to release neurotransmitters. Essential for fast vesicular exocytosis and activity-dependent neurotransmitter release as well as fast endocytosis that mediates rapid reuse of synaptic vesicles (By similarity) 1. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1....show less
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P63027 [Direct mapping] Vesicle-associated membrane protein 2
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Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Biotech drugs Human disease related genes Congenital malformations Congenital malformations of the nervous system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000149[SNARE binding] GO:0005484[SNAP receptor activity] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005543[phospholipid binding] GO:0005802[trans-Golgi network] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006887[exocytosis] GO:0006906[vesicle fusion] GO:0008021[synaptic vesicle] GO:0008076[voltage-gated potassium channel complex] GO:0009749[response to glucose] GO:0015031[protein transport] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016079[synaptic vesicle exocytosis] GO:0016192[vesicle-mediated transport] GO:0017075[syntaxin-1 binding] GO:0017156[calcium-ion regulated exocytosis] GO:0017157[regulation of exocytosis] GO:0019905[syntaxin binding] GO:0030136[clathrin-coated vesicle] GO:0030141[secretory granule] GO:0030667[secretory granule membrane] GO:0030669[clathrin-coated endocytic vesicle membrane] GO:0030672[synaptic vesicle membrane] GO:0031201[SNARE complex] GO:0031410[cytoplasmic vesicle] GO:0031982[vesicle] GO:0032869[cellular response to insulin stimulus] GO:0035493[SNARE complex assembly] GO:0042589[zymogen granule membrane] GO:0043001[Golgi to plasma membrane protein transport] GO:0043005[neuron projection] GO:0043231[intracellular membrane-bounded organelle] GO:0043308[eosinophil degranulation] GO:0043621[protein self-association] GO:0044306[neuron projection terminus] GO:0045202[synapse] GO:0048306[calcium-dependent protein binding] GO:0048471[perinuclear region of cytoplasm] GO:0048488[synaptic vesicle endocytosis] GO:0060203[clathrin-sculpted glutamate transport vesicle membrane] GO:0060291[long-term synaptic potentiation] GO:0060627[regulation of vesicle-mediated transport] GO:0061025[membrane fusion] GO:0061202[clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] GO:0065003[protein-containing complex assembly] GO:0070032[synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex] GO:0070033[synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex] GO:0070044[synaptobrevin 2-SNAP-25-syntaxin-1a complex] GO:0070083[clathrin-sculpted monoamine transport vesicle membrane] GO:0090316[positive regulation of intracellular protein transport] GO:0110165[cellular anatomical entity] GO:1902259[regulation of delayed rectifier potassium channel activity]
The Human Protein Atlas project is funded
