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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
FDA approved drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
p14
Chromosome location (bp)
68178857 - 68256237
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity....show less
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Calcium, Metal-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
Enables cyclosporin A binding activity; phosphatase binding activity; and protein domain specific binding activity. Involved in calcineurin-NFAT signaling cascade and positive regulation of transcription by RNA polymerase II. Part of calcineurin complex. Implicated in Alzheimer's disease and dilated cardiomyopathy. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P63098 [Direct mapping] Calcineurin subunit B type 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001569[branching involved in blood vessel morphogenesis] GO:0001837[epithelial to mesenchymal transition] GO:0004721[phosphoprotein phosphatase activity] GO:0004723[calcium-dependent protein serine/threonine phosphatase activity] GO:0005509[calcium ion binding] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005955[calcineurin complex] GO:0006470[protein dephosphorylation] GO:0006606[protein import into nucleus] GO:0007507[heart development] GO:0008287[protein serine/threonine phosphatase complex] GO:0008597[calcium-dependent protein serine/threonine phosphatase regulator activity] GO:0014044[Schwann cell development] GO:0016018[cyclosporin A binding] GO:0016020[membrane] GO:0019902[phosphatase binding] GO:0019904[protein domain specific binding] GO:0022011[myelination in peripheral nervous system] GO:0033173[calcineurin-NFAT signaling cascade] GO:0034504[protein localization to nucleus] GO:0042383[sarcolemma] GO:0045202[synapse] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0060487[lung epithelial cell differentiation] GO:0070886[positive regulation of calcineurin-NFAT signaling cascade] GO:0097720[calcineurin-mediated signaling] GO:0098685[Schaffer collateral - CA1 synapse] GO:0098686[hippocampal mossy fiber to CA3 synapse] GO:0098688[parallel fiber to Purkinje cell synapse] GO:0098693[regulation of synaptic vesicle cycle] GO:0098794[postsynapse] GO:0098978[glutamatergic synapse] GO:0099149[regulation of postsynaptic neurotransmitter receptor internalization] GO:0099170[postsynaptic modulation of chemical synaptic transmission] GO:1901386[negative regulation of voltage-gated calcium channel activity] GO:1901387[positive regulation of voltage-gated calcium channel activity] GO:1905665[positive regulation of calcium ion import across plasma membrane] GO:1905949[negative regulation of calcium ion import across plasma membrane]
F6U1T9 [Direct mapping] Calcineurin subunit B type 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
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GO:0005509[calcium ion binding] GO:0005829[cytosol] GO:0008597[calcium-dependent protein serine/threonine phosphatase regulator activity] GO:0046872[metal ion binding]
D3YTA9 [Direct mapping] Calcineurin subunit B type 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
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GO:0005509[calcium ion binding] GO:0005829[cytosol] GO:0008597[calcium-dependent protein serine/threonine phosphatase regulator activity] GO:0046872[metal ion binding]
The Human Protein Atlas project is funded
