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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Enzymes Human disease related genes Metabolic proteins Plasma proteins Potential drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
22
Cytoband
q11.23
Chromosome location (bp)
23894383 - 23895227
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Pro-inflammatory cytokine involved in the innate immune response to bacterial pathogens 1,2,3. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense 4,5,6. Counteracts the anti-inflammatory activity of glucocorticoids 7,8,9. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known 10,11. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity 12,13....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Cytokine, Isomerase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Immunity, Inflammatory response, Innate immunity
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Enzymes ENZYME proteins Isomerase Metabolic proteins Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Human disease related genes Immune system diseases Allergies and autoimmune diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001516[prostaglandin biosynthetic process] GO:0001819[positive regulation of cytokine production] GO:0001934[positive regulation of protein phosphorylation] GO:0002020[protease binding] GO:0002376[immune system process] GO:0002906[negative regulation of mature B cell apoptotic process] GO:0004167[dopachrome isomerase activity] GO:0005125[cytokine activity] GO:0005126[cytokine receptor binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006954[inflammatory response] GO:0007166[cell surface receptor signaling pathway] GO:0008284[positive regulation of cell population proliferation] GO:0009986[cell surface] GO:0010629[negative regulation of gene expression] GO:0010739[positive regulation of protein kinase A signaling] GO:0010760[negative regulation of macrophage chemotaxis] GO:0016853[isomerase activity] GO:0019752[carboxylic acid metabolic process] GO:0030330[DNA damage response, signal transduction by p53 class mediator] GO:0030336[negative regulation of cell migration] GO:0030890[positive regulation of B cell proliferation] GO:0031666[positive regulation of lipopolysaccharide-mediated signaling pathway] GO:0031982[vesicle] GO:0032760[positive regulation of tumor necrosis factor production] GO:0033033[negative regulation of myeloid cell apoptotic process] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0034774[secretory granule lumen] GO:0042056[chemoattractant activity] GO:0042127[regulation of cell population proliferation] GO:0042327[positive regulation of phosphorylation] GO:0042802[identical protein binding] GO:0043030[regulation of macrophage activation] GO:0043066[negative regulation of apoptotic process] GO:0043406[positive regulation of MAP kinase activity] GO:0043518[negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0045087[innate immune response] GO:0048146[positive regulation of fibroblast proliferation] GO:0050178[phenylpyruvate tautomerase activity] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0050918[positive chemotaxis] GO:0051248[negative regulation of protein metabolic process] GO:0061078[positive regulation of prostaglandin secretion involved in immune response] GO:0061081[positive regulation of myeloid leukocyte cytokine production involved in immune response] GO:0070062[extracellular exosome] GO:0070207[protein homotrimerization] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0090238[positive regulation of arachidonic acid secretion] GO:0090398[cellular senescence] GO:1902166[negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:1904813[ficolin-1-rich granule lumen] GO:2000343[positive regulation of chemokine (C-X-C motif) ligand 2 production] GO:2000773[negative regulation of cellular senescence]
The Human Protein Atlas project is funded
