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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
5
Cytoband
q22.3
Chromosome location (bp)
115578496 - 115602479
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Functions as sorting adapter in different signaling pathways to facilitate downstream signaling leading to type I interferon induction 1,2,3,4. In TLR4 signaling, physically bridges TLR4 and TICAM1 and functionally transmits signal to TICAM1 in early endosomes after endocytosis of TLR4. In TLR2 signaling, physically bridges TLR2 and MYD88 and is required for the TLR2-dependent movement of MYD88 to endosomes following ligand engagement 5. Involved in IL-18 signaling and is proposed to function as a sorting adapter for MYD88 in IL-18 signaling during adaptive immune response 6. Forms a complex with RAB11FIP2 that is recruited to the phagosomes to promote the activation of the actin-regulatory GTPases RAC1 and CDC42 and subsequent phagocytosis of Gram-negative bacteria 7....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Immunity, Inflammatory response, Innate immunity
Gene summary (Entrez)i
Useful information about the gene from Entrez
TIRP is a Toll/interleukin-1 receptor (IL1R; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4; MIM 603030).[supplied by OMIM, Apr 2004]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q86XR7 [Direct mapping] TIR domain-containing adapter molecule 2
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Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0001891[phagocytic cup] GO:0002376[immune system process] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005769[early endosome] GO:0005770[late endosome] GO:0005783[endoplasmic reticulum] GO:0005793[endoplasmic reticulum-Golgi intermediate compartment] GO:0005794[Golgi apparatus] GO:0005886[plasma membrane] GO:0006886[intracellular protein transport] GO:0006888[endoplasmic reticulum to Golgi vesicle-mediated transport] GO:0006909[phagocytosis] GO:0006954[inflammatory response] GO:0007030[Golgi organization] GO:0007165[signal transduction] GO:0010008[endosome membrane] GO:0016020[membrane] GO:0030134[COPII-coated ER to Golgi transport vesicle] GO:0030667[secretory granule membrane] GO:0031901[early endosome membrane] GO:0031902[late endosome membrane] GO:0034145[positive regulation of toll-like receptor 4 signaling pathway] GO:0035666[TRIF-dependent toll-like receptor signaling pathway] GO:0035669[TRAM-dependent toll-like receptor 4 signaling pathway] GO:0042995[cell projection] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045087[innate immune response] GO:0071222[cellular response to lipopolysaccharide] GO:0071651[positive regulation of chemokine (C-C motif) ligand 5 production] GO:2000494[positive regulation of interleukin-18-mediated signaling pathway]
The Human Protein Atlas project is funded
