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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Metabolic proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
3
Cytoband
p21.31
Chromosome location (bp)
50296402 - 50299416
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
N-alpha-acetyltransferase that specifically mediates the acetylation of the acidic amino terminus of processed forms of beta- and gamma-actin (ACTB and ACTG, respectively) 1,2. N-terminal acetylation of processed beta- and gamma-actin regulates actin filament depolymerization and elongation 3. In vivo, preferentially displays N-terminal acetyltransferase activity towards acid N-terminal sequences starting with Asp-Asp-Asp and Glu-Glu-Glu 4,5. In vitro, shows high activity towards Met-Asp-Glu-Leu and Met-Asp-Asp-Asp 6,7. May act as a tumor suppressor 8....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Acyltransferase, Transferase
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the N-acetyltransferase family. N-acetyltransferases modify proteins by transferring acetyl groups from acetyl CoA to the N-termini of protein substrates. The encoded protein is a cytoplasmic N-acetyltransferase with a substrate specificity for proteins with an N-terminal methionine. This gene is located in the tumor suppressor gene region on chromosome 3p21.3 and the encoded protein may play a role in cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed. This gene overlaps and is on the same strand as hyaluronoglucosaminidase 3, and some transcripts of each gene share a portion of the first exon. [provided by RefSeq, Jan 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004596[peptide alpha-N-acetyltransferase activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006473[protein acetylation] GO:0008064[regulation of actin polymerization or depolymerization] GO:0008080[N-acetyltransferase activity] GO:0016407[acetyltransferase activity] GO:0016740[transferase activity] GO:0016746[acyltransferase activity] GO:0016747[acyltransferase activity, transferring groups other than amino-acyl groups] GO:0017190[N-terminal peptidyl-aspartic acid acetylation] GO:0018002[N-terminal peptidyl-glutamic acid acetylation] GO:0030047[actin modification] GO:1905502[acetyl-CoA binding]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004596[peptide alpha-N-acetyltransferase activity] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006473[protein acetylation] GO:0008064[regulation of actin polymerization or depolymerization] GO:0008080[N-acetyltransferase activity] GO:0016407[acetyltransferase activity] GO:0016740[transferase activity] GO:0016746[acyltransferase activity] GO:0016747[acyltransferase activity, transferring groups other than amino-acyl groups] GO:0017190[N-terminal peptidyl-aspartic acid acetylation] GO:0018002[N-terminal peptidyl-glutamic acid acetylation] GO:0030047[actin modification] GO:1905502[acetyl-CoA binding]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004596[peptide alpha-N-acetyltransferase activity] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006473[protein acetylation] GO:0008064[regulation of actin polymerization or depolymerization] GO:0008080[N-acetyltransferase activity] GO:0016407[acetyltransferase activity] GO:0016740[transferase activity] GO:0016746[acyltransferase activity] GO:0016747[acyltransferase activity, transferring groups other than amino-acyl groups] GO:0017190[N-terminal peptidyl-aspartic acid acetylation] GO:0018002[N-terminal peptidyl-glutamic acid acetylation] GO:0030047[actin modification] GO:1905502[acetyl-CoA binding]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004596[peptide alpha-N-acetyltransferase activity] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006473[protein acetylation] GO:0008064[regulation of actin polymerization or depolymerization] GO:0008080[N-acetyltransferase activity] GO:0016407[acetyltransferase activity] GO:0016740[transferase activity] GO:0016746[acyltransferase activity] GO:0016747[acyltransferase activity, transferring groups other than amino-acyl groups] GO:0017190[N-terminal peptidyl-aspartic acid acetylation] GO:0018002[N-terminal peptidyl-glutamic acid acetylation] GO:0030047[actin modification] GO:1905502[acetyl-CoA binding]
The Human Protein Atlas project is funded
