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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes CD markers Disease related genes FDA approved drug targets Human disease related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
q21.32
Chromosome location (bp)
47253827 - 47313743
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and acts as its coreceptor in CX3CR1-dependent fractalkine signaling 1,2. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling 3. ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling 4. ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling 5. ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling 6. ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling 7. ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling 8. ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 9,10. ITGAV:ITGB3 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 11. In brain, plays a role in synaptic transmission and plasticity. Involved in the regulation of the serotonin neurotransmission, is required to localize to specific compartments within the synapse the serotonin receptor SLC6A4 and for an appropriate reuptake of serotonin. Controls excitatory synaptic strength by regulating GRIA2-containing AMPAR endocytosis, which affects AMPAR abundance and composition (By similarity). ITGAV:ITGB3 act as a receptor for CD40LG 12....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Host cell receptor for virus entry, Integrin, Receptor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Cell adhesion, Host-virus interaction
Gene summary (Entrez)i
Useful information about the gene from Entrez
The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Human disease related genes Cardiovascular diseases Cardiac diseases Hematologic diseases Immune system diseases Allergies and autoimmune diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618[virus receptor activity] GO:0001934[positive regulation of protein phosphorylation] GO:0001938[positive regulation of endothelial cell proliferation] GO:0001954[positive regulation of cell-matrix adhesion] GO:0001968[fibronectin binding] GO:0002020[protease binding] GO:0002687[positive regulation of leukocyte migration] GO:0003756[protein disulfide isomerase activity] GO:0005080[protein kinase C binding] GO:0005161[platelet-derived growth factor receptor binding] GO:0005178[integrin binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005886[plasma membrane] GO:0005911[cell-cell junction] GO:0005925[focal adhesion] GO:0007044[cell-substrate junction assembly] GO:0007155[cell adhesion] GO:0007160[cell-matrix adhesion] GO:0007229[integrin-mediated signaling pathway] GO:0007566[embryo implantation] GO:0007596[blood coagulation] GO:0008277[regulation of G protein-coupled receptor signaling pathway] GO:0008305[integrin complex] GO:0009314[response to radiation] GO:0009897[external side of plasma membrane] GO:0009986[cell surface] GO:0010595[positive regulation of endothelial cell migration] GO:0010628[positive regulation of gene expression] GO:0010745[negative regulation of macrophage derived foam cell differentiation] GO:0010763[positive regulation of fibroblast migration] GO:0010888[negative regulation of lipid storage] GO:0014823[response to activity] GO:0014909[smooth muscle cell migration] GO:0014911[positive regulation of smooth muscle cell migration] GO:0015026[coreceptor activity] GO:0016020[membrane] GO:0016324[apical plasma membrane] GO:0016477[cell migration] GO:0017134[fibroblast growth factor binding] GO:0019899[enzyme binding] GO:0019960[C-X3-C chemokine binding] GO:0030168[platelet activation] GO:0030335[positive regulation of cell migration] GO:0030949[positive regulation of vascular endothelial growth factor receptor signaling pathway] GO:0031092[platelet alpha granule membrane] GO:0031258[lamellipodium membrane] GO:0031527[filopodium membrane] GO:0031528[microvillus membrane] GO:0031589[cell-substrate adhesion] GO:0031994[insulin-like growth factor I binding] GO:0032147[activation of protein kinase activity] GO:0032369[negative regulation of lipid transport] GO:0032587[ruffle membrane] GO:0032880[regulation of protein localization] GO:0032956[regulation of actin cytoskeleton organization] GO:0032991[protein-containing complex] GO:0033627[cell adhesion mediated by integrin] GO:0033630[positive regulation of cell adhesion mediated by integrin] GO:0033690[positive regulation of osteoblast proliferation] GO:0034113[heterotypic cell-cell adhesion] GO:0034446[substrate adhesion-dependent cell spreading] GO:0034683[integrin alphav-beta3 complex] GO:0035295[tube development] GO:0035866[alphav-beta3 integrin-PKCalpha complex] GO:0035867[alphav-beta3 integrin-IGF-1-IGF1R complex] GO:0035868[alphav-beta3 integrin-HMGB1 complex] GO:0036119[response to platelet-derived growth factor] GO:0036120[cellular response to platelet-derived growth factor stimulus] GO:0038027[apolipoprotein A-I-mediated signaling pathway] GO:0038132[neuregulin binding] GO:0042060[wound healing] GO:0042470[melanosome] GO:0042802[identical protein binding] GO:0042995[cell projection] GO:0043184[vascular endothelial growth factor receptor 2 binding] GO:0043235[receptor complex] GO:0043277[apoptotic cell clearance] GO:0045124[regulation of bone resorption] GO:0045202[synapse] GO:0045211[postsynaptic membrane] GO:0045766[positive regulation of angiogenesis] GO:0045780[positive regulation of bone resorption] GO:0046718[viral entry into host cell] GO:0048008[platelet-derived growth factor receptor signaling pathway] GO:0048146[positive regulation of fibroblast proliferation] GO:0048333[mesodermal cell differentiation] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0050748[negative regulation of lipoprotein metabolic process] GO:0050839[cell adhesion molecule binding] GO:0050840[extracellular matrix binding] GO:0050919[negative chemotaxis] GO:0051279[regulation of release of sequestered calcium ion into cytosol] GO:0051611[regulation of serotonin uptake] GO:0060055[angiogenesis involved in wound healing] GO:0060548[negative regulation of cell death] GO:0061097[regulation of protein tyrosine kinase activity] GO:0070051[fibrinogen binding] GO:0070062[extracellular exosome] GO:0070161[anchoring junction] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0070527[platelet aggregation] GO:0071062[alphav-beta3 integrin-vitronectin complex] GO:0071133[alpha9-beta1 integrin-ADAM8 complex] GO:0071260[cellular response to mechanical stimulus] GO:0071466[cellular response to xenobiotic stimulus] GO:0072126[positive regulation of glomerular mesangial cell proliferation] GO:0097060[synaptic membrane] GO:0098690[glycinergic synapse] GO:0098880[maintenance of postsynaptic specialization structure] GO:0098978[glutamatergic synapse] GO:0099149[regulation of postsynaptic neurotransmitter receptor internalization] GO:0150054[regulation of postsynaptic neurotransmitter receptor diffusion trapping] GO:1900026[positive regulation of substrate adhesion-dependent cell spreading] GO:1900731[positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway] GO:1901163[regulation of trophoblast cell migration] GO:1903053[regulation of extracellular matrix organization] GO:1905598[negative regulation of low-density lipoprotein receptor activity] GO:1990314[cellular response to insulin-like growth factor stimulus] GO:2000406[positive regulation of T cell migration]
The Human Protein Atlas project is funded
