GENERAL INFORMATIONi
Gene namei IKBKG
Synonyms FIP-3, FIP3, Fip3p, IKK-gamma, IKKAP1, IKKG, IP1, IP2, NEMO, ZC2HC9
Gene descriptioni Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
Protein classi Disease related genes
Human disease related genes
RAS pathway related proteins
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome X
Cytoband q28
Chromosome location (bp) 154541199 - 154565046
Number of transcriptsi 16
Ensembl ENSG00000269335 (version 109)
Entrez gene 8517
HGNC HGNC:5961
UniProt Q9Y6K9 (UniProt - Evidence at protein level)
neXtProt NX_Q9Y6K9
GeneCards IKBKG
Antibodypedia IKBKG antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor 1, 2, 3. Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways 4, 5, 6, 7, 8, 9, 10. Can recognize and bind both 'Lys-63'-linked and linear polyubiquitin upon cell stimulation, with a much higher affinity for linear polyubiquitin 11, 12, 13, 14, 15, 16. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3 17. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'- linked polyubiquitination 18. show less
Biological process (UniProt)i DNA damage, Host-virus interaction, Transcription, Transcription regulation
Ligand (UniProt)i Metal-binding, Zinc
Gene summary (Entrez)i This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Mar 2016] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
IKBKG-201
ENSP00000398579
ENST00000413620
C9J2V2
[Direct mapping] NF-kappa-B essential modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Congenital malformations of skin
   Immune system diseases
   Allergies and autoimmune diseases
   Primary immunodeficiency
Show all
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0046872 [metal ion binding]
GO:0070530 [K63-linked polyubiquitin modification-dependent protein binding]
Show all
 407 aa
46.7 kDa 		No 0
IKBKG-202
ENSP00000390368
ENST00000422680
Q9Y6K9
[Direct mapping] NF-kappa-B essential modulator
Show all
C9JH59
[Direct mapping] NF-kappa-B essential modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Congenital malformations of skin
   Immune system diseases
   Allergies and autoimmune diseases
   Primary immunodeficiency
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0008385 [IkappaB kinase complex]
GO:0009615 [response to virus]
GO:0016239 [positive regulation of macroautophagy]
GO:0019904 [protein domain specific binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032991 [protein-containing complex]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043276 [anoikis]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0050852 [T cell receptor signaling pathway]
GO:0050862 [positive regulation of T cell receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051650 [establishment of vesicle localization]
GO:0065003 [protein-containing complex assembly]
GO:0070530 [K63-linked polyubiquitin modification-dependent protein binding]
GO:0072686 [mitotic spindle]
GO:1901215 [negative regulation of neuron death]
GO:1990450 [linear polyubiquitin binding]
GO:1990459 [transferrin receptor binding]
Show all
 419 aa
48.2 kDa 		No 0
IKBKG-203
ENSP00000394934
ENST00000440286
Q9Y6K9
[Direct mapping] NF-kappa-B essential modulator
Show all
C9JN51
[Direct mapping] NF-kappa-B essential modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Congenital malformations of skin
   Immune system diseases
   Allergies and autoimmune diseases
   Primary immunodeficiency
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0008385 [IkappaB kinase complex]
GO:0009615 [response to virus]
GO:0016239 [positive regulation of macroautophagy]
GO:0019904 [protein domain specific binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032991 [protein-containing complex]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043276 [anoikis]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0050852 [T cell receptor signaling pathway]
GO:0050862 [positive regulation of T cell receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051650 [establishment of vesicle localization]
GO:0065003 [protein-containing complex assembly]
GO:0070530 [K63-linked polyubiquitin modification-dependent protein binding]
GO:0072686 [mitotic spindle]
GO:1901215 [negative regulation of neuron death]
GO:1990450 [linear polyubiquitin binding]
GO:1990459 [transferrin receptor binding]
Show all
 419 aa
48.2 kDa 		No 0
IKBKG-204
ENSP00000395205
ENST00000445622
Q9Y6K9
[Direct mapping] NF-kappa-B essential modulator
Show all
C9JCG6
[Direct mapping] NF-kappa-B essential modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Congenital malformations of skin
   Immune system diseases
   Allergies and autoimmune diseases
   Primary immunodeficiency
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0008385 [IkappaB kinase complex]
GO:0009615 [response to virus]
GO:0016239 [positive regulation of macroautophagy]
GO:0019904 [protein domain specific binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032991 [protein-containing complex]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043276 [anoikis]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0050852 [T cell receptor signaling pathway]
GO:0050862 [positive regulation of T cell receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051650 [establishment of vesicle localization]
GO:0065003 [protein-containing complex assembly]
GO:0070530 [K63-linked polyubiquitin modification-dependent protein binding]
GO:0072686 [mitotic spindle]
GO:1901215 [negative regulation of neuron death]
GO:1990450 [linear polyubiquitin binding]
GO:1990459 [transferrin receptor binding]
Show all
 419 aa
48.2 kDa 		No 0
IKBKG-205
ENSP00000484275
ENST00000492469
A0A087X1K7
[Direct mapping] NF-kappa-B essential modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Congenital malformations of skin
   Immune system diseases
   Allergies and autoimmune diseases
   Primary immunodeficiency
Show all
 237 aa
26.7 kDa 		No 0
IKBKG-206
ENSP00000471166
ENST00000594239
Q9Y6K9
[Direct mapping] NF-kappa-B essential modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Congenital malformations of skin
   Immune system diseases
   Allergies and autoimmune diseases
   Primary immunodeficiency
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0008385 [IkappaB kinase complex]
GO:0009615 [response to virus]
GO:0016239 [positive regulation of macroautophagy]
GO:0019904 [protein domain specific binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032991 [protein-containing complex]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043276 [anoikis]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0050852 [T cell receptor signaling pathway]
GO:0050862 [positive regulation of T cell receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051650 [establishment of vesicle localization]
GO:0065003 [protein-containing complex assembly]
GO:0070530 [K63-linked polyubiquitin modification-dependent protein binding]
GO:0072686 [mitotic spindle]
GO:1901215 [negative regulation of neuron death]
GO:1990450 [linear polyubiquitin binding]
GO:1990459 [transferrin receptor binding]
Show all
 419 aa
48.2 kDa 		No 0
IKBKG-207
ENSP00000479662
ENST00000611071
Q9Y6K9
[Direct mapping] NF-kappa-B essential modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Congenital malformations of skin
   Immune system diseases
   Allergies and autoimmune diseases
   Primary immunodeficiency
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0008385 [IkappaB kinase complex]
GO:0009615 [response to virus]
GO:0016239 [positive regulation of macroautophagy]
GO:0019904 [protein domain specific binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032991 [protein-containing complex]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043276 [anoikis]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0050852 [T cell receptor signaling pathway]
GO:0050862 [positive regulation of T cell receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051650 [establishment of vesicle localization]
GO:0065003 [protein-containing complex assembly]
GO:0070530 [K63-linked polyubiquitin modification-dependent protein binding]
GO:0072686 [mitotic spindle]
GO:1901215 [negative regulation of neuron death]
GO:1990450 [linear polyubiquitin binding]
GO:1990459 [transferrin receptor binding]
Show all
 419 aa
48.2 kDa 		No 0
IKBKG-208
ENSP00000478616
ENST00000611176
Q9Y6K9
[Direct mapping] NF-kappa-B essential modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Congenital malformations of skin
   Immune system diseases
   Allergies and autoimmune diseases
   Primary immunodeficiency
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0008385 [IkappaB kinase complex]
GO:0009615 [response to virus]
GO:0016239 [positive regulation of macroautophagy]
GO:0019904 [protein domain specific binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032991 [protein-containing complex]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043276 [anoikis]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0050852 [T cell receptor signaling pathway]
GO:0050862 [positive regulation of T cell receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051650 [establishment of vesicle localization]
GO:0065003 [protein-containing complex assembly]
GO:0070530 [K63-linked polyubiquitin modification-dependent protein binding]
GO:0072686 [mitotic spindle]
GO:1901215 [negative regulation of neuron death]
GO:1990450 [linear polyubiquitin binding]
GO:1990459 [transferrin receptor binding]
Show all
 320 aa
37 kDa 		No 0
IKBKG-210
ENSP00000479144
ENST00000615186
D3DWY0
[Direct mapping] Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, isoform CRA_b; NF-kappa-B essential modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Congenital malformations of skin
   Immune system diseases
   Allergies and autoimmune diseases
   Primary immunodeficiency
Show all
GO:0005737 [cytoplasm]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0046872 [metal ion binding]
GO:0070530 [K63-linked polyubiquitin modification-dependent protein binding]
Show all
 285 aa
32.5 kDa 		No 0
IKBKG-211
ENSP00000483381
ENST00000615874
A0A087X0G7
[Direct mapping] NF-kappa-B essential modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Congenital malformations of skin
   Immune system diseases
   Allergies and autoimmune diseases
   Primary immunodeficiency
Show all
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0046872 [metal ion binding]
GO:0070530 [K63-linked polyubiquitin modification-dependent protein binding]
Show all
 411 aa
47.3 kDa 		No 0
IKBKG-212
ENSP00000484023
ENST00000617207
A0A087X1B1
[Direct mapping] NF-kappa-B essential modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Congenital malformations of skin
   Immune system diseases
   Allergies and autoimmune diseases
   Primary immunodeficiency
Show all
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0046872 [metal ion binding]
GO:0070530 [K63-linked polyubiquitin modification-dependent protein binding]
Show all
 418 aa
48.1 kDa 		No 0
IKBKG-214
ENSP00000483825
ENST00000618670
Q9Y6K9
[Direct mapping] NF-kappa-B essential modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Congenital malformations of skin
   Immune system diseases
   Allergies and autoimmune diseases
   Primary immunodeficiency
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0008385 [IkappaB kinase complex]
GO:0009615 [response to virus]
GO:0016239 [positive regulation of macroautophagy]
GO:0019904 [protein domain specific binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032991 [protein-containing complex]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043276 [anoikis]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0050852 [T cell receptor signaling pathway]
GO:0050862 [positive regulation of T cell receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051650 [establishment of vesicle localization]
GO:0065003 [protein-containing complex assembly]
GO:0070530 [K63-linked polyubiquitin modification-dependent protein binding]
GO:0072686 [mitotic spindle]
GO:1901215 [negative regulation of neuron death]
GO:1990450 [linear polyubiquitin binding]
GO:1990459 [transferrin receptor binding]
Show all
 487 aa
55.8 kDa 		No 0
IKBKG-215
ENSP00000478979
ENST00000619941
A0A087WUW6
[Direct mapping] NF-kappa-B essential modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Congenital malformations of skin
   Immune system diseases
   Allergies and autoimmune diseases
   Primary immunodeficiency
Show all
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0046872 [metal ion binding]
GO:0070530 [K63-linked polyubiquitin modification-dependent protein binding]
Show all
 412 aa
47.4 kDa 		No 0
IKBKG-216
ENSP00000509444
ENST00000686378
A0A8I5KRU9
[Direct mapping] NF-kappa-B essential modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Congenital malformations of skin
   Immune system diseases
   Allergies and autoimmune diseases
   Primary immunodeficiency
Show all
 145 aa
16.7 kDa 		No 0
IKBKG-219
ENSP00000508630
ENST00000689906
A0A8I5KQX5
[Direct mapping] NF-kappa-B essential modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Congenital malformations of skin
   Immune system diseases
   Allergies and autoimmune diseases
   Primary immunodeficiency
Show all
GO:0005737 [cytoplasm]
GO:0046872 [metal ion binding]
GO:0070530 [K63-linked polyubiquitin modification-dependent protein binding]
Show all
 368 aa
42.4 kDa 		No 0
IKBKG-221
ENSP00000508773
ENST00000692948
A0A8I5KQX1
[Direct mapping] NF-kappa-B essential modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Congenital malformations of skin
   Immune system diseases
   Allergies and autoimmune diseases
   Primary immunodeficiency
Show all
GO:0005737 [cytoplasm]
GO:0046872 [metal ion binding]
GO:0070530 [K63-linked polyubiquitin modification-dependent protein binding]
Show all
 438 aa
50.3 kDa 		No 0

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