TBCE gene information - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TBCE
Synonyms	HRD, KCS, KCS1, pac2
Gene descriptionⁱ Full gene name according to HGNC.	Tubulin folding cofactor E
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Protein evidence	Evidence at protein level (all genes)

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome	1
Cytoband	q42.3
Chromosome location (bp)	235328570 - 235448952
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8
Ensembl	ENSG00000285053 (version 109)
Entrez gene	6905
HGNC	HGNC:11582
UniProt	Q15813 (UniProt - Evidence at protein level)
neXtProt	NX_Q15813
GeneCards	TBCE
Antibodypedia	TBCE antibodies

PROTEIN FUNCTION
Protein function (UniProt)ⁱ Useful information about the protein provided by UniProt.	Tubulin-folding protein; involved in the second step of the tubulin folding pathway and in the regulation of tubulin heterodimer dissociation. Required for correct organization of microtubule cytoskeleton and mitotic splindle, and maintenance of the neuronal microtubule network.... show less
Molecular function (UniProt)ⁱ Keywords assigned by UniProt to proteins due to their particular molecular function.	Chaperone
Gene summary (Entrez)ⁱ Useful information about the gene from Entrez	Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]... show less

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant	SwissProt	TrEMBL	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TBCE-281 ENSP00000496048 ENST00000643758		A0A2R8YF12 [Direct mapping] Tubulin-specific chaperone E Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Other congenital malformations Show all	GO:0006457 [protein folding] GO:0043014 [alpha-tubulin binding] Show all	61 aa 6.6 kDa	No	0
TBCE-286 ENSP00000495823 ENST00000645205	Q15813 [Direct mapping] Tubulin-specific chaperone E Show all		Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Show all	GO:0000226 [microtubule cytoskeleton organization] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005874 [microtubule] GO:0006457 [protein folding] GO:0007021 [tubulin complex assembly] GO:0007023 [post-chaperonin tubulin folding pathway] GO:0007052 [mitotic spindle organization] GO:0043014 [alpha-tubulin binding] GO:0051087 [chaperone binding] Show all	527 aa 59.3 kDa	No	0
TBCE-287 ENSP00000494319 ENST00000645351	Q15813 [Direct mapping] Tubulin-specific chaperone E Show all		Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Show all	GO:0000226 [microtubule cytoskeleton organization] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005874 [microtubule] GO:0006457 [protein folding] GO:0007021 [tubulin complex assembly] GO:0007023 [post-chaperonin tubulin folding pathway] GO:0007052 [mitotic spindle organization] GO:0043014 [alpha-tubulin binding] GO:0051087 [chaperone binding] Show all	527 aa 59.3 kDa	No	0
TBCE-289 ENSP00000495202 ENST00000645655	Q15813 [Direct mapping] Tubulin-specific chaperone E Show all		Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Show all	GO:0000226 [microtubule cytoskeleton organization] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005874 [microtubule] GO:0006457 [protein folding] GO:0007021 [tubulin complex assembly] GO:0007023 [post-chaperonin tubulin folding pathway] GO:0007052 [mitotic spindle organization] GO:0043014 [alpha-tubulin binding] GO:0051087 [chaperone binding] Show all	527 aa 59.3 kDa	No	0
TBCE-291 ENSP00000495225 ENST00000646281		A0A2R8YFL4 [Direct mapping] Tubulin-specific chaperone E Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Other congenital malformations Show all	GO:0006457 [protein folding] GO:0043014 [alpha-tubulin binding] Show all	370 aa 40.9 kDa	No	0
TBCE-293 ENSP00000494575 ENST00000646624	Q15813 [Direct mapping] Tubulin-specific chaperone E Show all		Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Show all	GO:0000226 [microtubule cytoskeleton organization] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005874 [microtubule] GO:0006457 [protein folding] GO:0007021 [tubulin complex assembly] GO:0007023 [post-chaperonin tubulin folding pathway] GO:0007052 [mitotic spindle organization] GO:0043014 [alpha-tubulin binding] GO:0051087 [chaperone binding] Show all	527 aa 59.3 kDa	No	0
TBCE-294 ENSP00000494775 ENST00000647186	Q15813 [Direct mapping] Tubulin-specific chaperone E Show all		Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Show all	GO:0000226 [microtubule cytoskeleton organization] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005874 [microtubule] GO:0006457 [protein folding] GO:0007021 [tubulin complex assembly] GO:0007023 [post-chaperonin tubulin folding pathway] GO:0007052 [mitotic spindle organization] GO:0043014 [alpha-tubulin binding] GO:0051087 [chaperone binding] Show all	527 aa 59.3 kDa	No	0
TBCE-295 ENSP00000495630 ENST00000647428		A0A2R8Y6Q1 [Direct mapping] Tubulin-specific chaperone E; Tubulin-specific chaperone e, isoform CRA_b Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Other congenital malformations Show all	GO:0005515 [protein binding] GO:0005856 [cytoskeleton] GO:0006457 [protein folding] GO:0043014 [alpha-tubulin binding] Show all	414 aa 46.9 kDa	No	0