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On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.
Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.
If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.
h
m
l
n
Glial cells:
Not detected
Neuronal cells:
Not detected
RNA expressioni
A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.
The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.
Scroll down to view mRNA expression data in more detail.
Consensus:
172.9
nTPM
HPA Brain:
406.4
nTPM
GTEx:
172.9
nTPM
FANTOM5:
177.8
Scaled Tags Per Million
Pig:
346.4
nTPM
Mouse:
288.3
nTPM
HIPPOCAMPUS - Antibody stainingi
Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells.
Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.
Antibody HPA000397
Antibody CAB021929
Glial cells
Not detected
Not detected
Neuronal cells
Not detected
Not detected
HIPPOCAMPAL FORMATION - HPA Brain RNA-seq
Max nTPM
406.4
Sample id
Sample description
nTPM
Hippocampus nTPM: 320.1
2621
Female, age 67, right hemisphere
454.3
1855
Male, age 76, left hemisphere
391.9
1898
Male, age 80, left hemisphere
388.2
2148
Female, age 91, left hemisphere
316.1
2529
Female, age 94, left hemisphere
190.2
1911
Female, age 85, right hemisphere
179.9
Dentate gyrus nTPM: 333.1
2530
Female, age 94, left hemisphere
448.5
1927
Female, age 91, both hemispheres
387.8
2010
Male, age 76, both hemispheres
340.1
2531
Female, age 67, both hemispheres
320.6
2246
Female, age 85, both hemispheres
266.8
2528
Male, age 74, both hemispheres
235.0
Entorhinal gyrus nTPM: 333.6
2613
Female, age 94, left hemisphere
452.2
2764
Male, age 80, right hemisphere
378.0
1938
Female, age 85, left hemisphere
330.0
2686
Male, age 75, right hemisphere
329.9
1787
Male, age 76, left hemisphere
301.1
2117
Female, age 91, right hemisphere
210.3
Hippocampus, CA1 nTPM: 330.4
2749
Male, age 80, left hemisphere
475.2
2045
Male, age 76, both hemispheres
334.6
1873
Female, age 85, both hemispheres
334.0
2527
Male, age 74, both hemispheres
305.9
2082
Female, age 91, right hemisphere
202.3
Hippocampus, CA2 nTPM: 282.9
1892
Male, age 76, both hemispheres
389.4
1963
Male, age 80, left hemisphere
343.5
2437
Female, age 94, left hemisphere
304.5
1940
Female, age 85, left hemisphere
251.4
2113
Female, age 91, right hemisphere
214.1
2249
Male, age 74, both hemispheres
194.2
Hippocampus, CA3 nTPM: 308.2
2861
Female, age 67, both hemispheres
460.2
2620
Female, age 94, left hemisphere
412.7
2137
Male, age 80, left hemisphere
328.6
1867
Male, age 76, both hemispheres
251.3
2436
Male, age 74, both hemispheres
218.8
1891
Female, age 85, both hemispheres
177.3
Parahippocampal cortex nTPM: 345.1
2245
Female, age 91, both hemispheres
501.8
2622
Female, age 67, right hemisphere
414.7
2693
Female, age 94, both hemispheres
401.1
1850
Male, age 80, both hemispheres
360.2
2532
Female, age 72, left hemisphere
348.2
1933
Female, age 85, both hemispheres
318.0
2250
Female, age 67, right hemisphere
317.9
1990
Female, age 91, right hemisphere
312.5
2018
Male, age 76, both hemispheres
251.5
2692
Male, age 74, both hemispheres
224.7
Perirhinal gyrus nTPM: 406.4
1847
Female, age 91, left hemisphere
452.9
1794
Male, age 80, right hemisphere
443.0
2521
Female, age 94, right hemisphere
442.5
2848
Male, age 76, right hemisphere
360.9
1841
Female, age 85, right hemisphere
332.8
Subiculum nTPM: 223.7
1977
Female, age 85, both hemispheres
265.1
2619
Male, age 74, both hemispheres
242.3
1901
Male, age 80, both hemispheres
241.5
2438
Female, age 94, left hemisphere
231.9
2729
Female, age 91, right hemisphere
187.8
2042
Male, age 76, both hemispheres
173.3
HIPPOCAMPAL FORMATION - GTEx RNA-seqi
RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.
Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Average nTPM
172.9
GTEx sample id
Sample description
nTPM
Brain - Hippocampus Average nTPM: 172.9
Samples: 197
Max nTPM: 699.2
Min nTPM: 3.1
Std nTPM: 129.7
Median nTPM: 158.1
GTEX-13O3O-0011-R1b-SM-5KM2K
60-69 years, female
699.2
GTEX-N7MS-0011-R1a-SM-2HMJG
60-69 years, male
659.2
GTEX-1EX96-0011-R1a-SM-CE6R5
50-59 years, male
623.7
GTEX-139TT-0011-R1a-SM-5LZVD
60-69 years, male
613.2
GTEX-1EMGI-0011-R1b-SM-9OSWZ
60-69 years, male
481.7
GTEX-1AX9I-0011-R1b-SM-7RHG2
60-69 years, male
473.8
GTEX-1I1GS-0011-R1a-SM-CJI43
60-69 years, male
461.3
GTEX-WHSE-0011-R1A-SM-3P5ZK
20-29 years, male
442.4
GTEX-13JUV-0011-R1a-SM-5LZY4
40-49 years, female
426.9
GTEX-1GTWX-0011-R1a-SM-CE6RL
60-69 years, male
411.8
GTEX-P44G-0011-R1A-SM-2I3FE
30-39 years, male
397.7
GTEX-13O3Q-0011-R1b-SM-5KM3L
50-59 years, male
386.5
GTEX-1H3NZ-0011-R1a-SM-CKZP5
60-69 years, male
385.1
GTEX-14JIY-0011-R1a-SM-68713
60-69 years, male
373.5
GTEX-1GZ2Q-0011-R1a-SM-CJI2Y
40-49 years, male
369.6
GTEX-1H1ZS-0011-R1b-SM-A9G1E
70-79 years, male
367.0
GTEX-131XH-0011-R1a-SM-5DUWA
50-59 years, male
363.9
GTEX-1ICLZ-0011-R1b-SM-A9SM3
60-69 years, male
359.8
GTEX-TSE9-0011-R1A-SM-3DB7E
60-69 years, female
353.9
GTEX-1EWIQ-0011-R1a-SM-9OSX7
70-79 years, female
338.6
GTEX-1B8SF-0011-R1b-SM-7P8Q8
60-69 years, male
330.1
GTEX-13FLW-0011-R1b-SM-5LZX2
50-59 years, male
309.1
GTEX-YFC4-0011-R1a-SM-4V6EH
40-49 years, female
308.3
GTEX-PVOW-0011-R1A-SM-32PL6
40-49 years, male
305.1
GTEX-1J1OQ-0011-R1a-SM-A9G1Z
40-49 years, female
305.0
GTEX-1IKK5-0011-R1b-SM-CE6SQ
60-69 years, male
304.3
GTEX-12WSM-0011-R1a-SM-5LZW6
60-69 years, male
293.1
GTEX-1CB4G-0011-R1b-SM-9QEHT
60-69 years, male
289.3
GTEX-1F75A-0011-R1b-SM-CE6RA
50-59 years, male
285.0
GTEX-1GF9W-0011-R1a-SM-9QEIQ
60-69 years, male
284.8
GTEX-1E1VI-0011-R1a-SM-ARZMM
50-59 years, male
284.4
GTEX-1HT8W-0011-R1b-SM-CJI3V
30-39 years, male
283.8
GTEX-N7MT-0011-R1a-SM-CNPO1
60-69 years, female
279.9
GTEX-1IOXB-0011-R1a-SM-D4P27
50-59 years, male
279.0
GTEX-1IDJH-0011-R1b-SM-ARU6U
70-79 years, male
277.0
GTEX-X585-0011-R1B-SM-46MVE
50-59 years, male
273.5
GTEX-12WSE-0011-R1b-SM-5GU4V
20-29 years, male
271.1
GTEX-Q2AG-0011-R1A-SM-2HMJI
40-49 years, female
268.4
GTEX-1F48J-0011-R1a-SM-9QEIC
50-59 years, female
264.0
GTEX-1F6I4-0011-R1a-SM-9OSWU
60-69 years, male
263.2
GTEX-145MH-0011-R1b-SM-5PNWY
50-59 years, male
260.6
GTEX-WL46-0011-R1A-SM-3LK6M
50-59 years, male
256.7
GTEX-14E6D-0011-R1b-SM-5YYAW
50-59 years, male
256.6
GTEX-11GSP-0011-R1a-SM-9QEJ3
60-69 years, female
252.2
GTEX-12WSD-0011-R1b-SM-5LZVY
60-69 years, female
251.4
GTEX-13112-0011-R1b-SM-5HL7K
50-59 years, male
247.3
GTEX-14ASI-0011-R1b-SM-5S2TY
60-69 years, male
247.2
GTEX-S7SE-0011-R1A-SM-2XCDE
50-59 years, male
245.4
GTEX-13X6I-0011-R1b-SM-5PNZC
60-69 years, male
243.5
GTEX-R55E-0011-R1A-SM-2TC6N
20-29 years, male
237.4
GTEX-1IY9M-0011-R1a-SM-EXURZ
60-69 years, male
236.9
GTEX-11GS4-0011-R1a-SM-DO129
60-69 years, male
235.3
GTEX-13FXS-0011-R1a-SM-5K7U6
50-59 years, male
233.6
GTEX-14C5O-0011-R1b-SM-6AJBW
60-69 years, male
229.9
GTEX-WWYW-0011-R1A-SM-3TW8G
50-59 years, female
225.3
GTEX-RNOR-0011-R1A-SM-CNNP5
50-59 years, female
225.2
GTEX-144GL-0011-R1a-SM-5PNZ5
50-59 years, male
222.3
GTEX-1GMR8-0011-R1b-SM-CJI2O
50-59 years, female
220.3
GTEX-NL3H-0011-R1a-SM-48TDJ
60-69 years, male
219.8
GTEX-1A3MX-0011-R1b-SM-7P8PH
60-69 years, male
218.7
GTEX-YJ89-0011-R1a-SM-4RGLS
60-69 years, male
216.3
GTEX-13NYB-0011-R1b-SM-5KM4F
40-49 years, male
213.7
GTEX-12WSF-0011-R1a-SM-5DUVI
70-79 years, male
212.7
GTEX-Y8DK-0011-R1A-SM-4RGLO
60-69 years, male
212.7
GTEX-14LLW-0011-R1a-SM-5ZZVD
70-79 years, female
212.5
GTEX-1GN1U-0011-R1a-SM-CJI25
50-59 years, female
210.4
GTEX-ZDXO-0011-R1a-SM-4WKF4
60-69 years, male
208.9
GTEX-T6MN-0011-R1A-SM-32QOY
50-59 years, male
208.3
GTEX-14ABY-0011-R1a-SM-6EU2W
50-59 years, male
205.7
GTEX-13G51-0011-R1a-SM-5LZYR
60-69 years, male
202.8
GTEX-16Z82-0011-R1b-SM-7EPHZ
60-69 years, male
199.5
GTEX-139T8-0011-R1a-SM-5HL75
60-69 years, male
197.5
GTEX-14BIM-0011-R1a-SM-69LQI
60-69 years, female
197.4
GTEX-1I1HK-0011-R1b-SM-CM2T7
60-69 years, male
195.9
GTEX-16YQH-0011-R1a-SM-7LT8R
30-39 years, male
195.5
GTEX-1HSKV-0011-R1b-SM-CMKH7
60-69 years, male
195.5
GTEX-17HG3-0011-R1a-SM-7LG6H
30-39 years, female
194.7
GTEX-T5JC-0011-R1A-SM-32PM6
20-29 years, male
193.2
GTEX-1C6VR-0011-R1a-SM-7MXUE
60-69 years, male
191.3
GTEX-QDT8-0011-R1A-SM-32PKS
30-39 years, female
190.5
GTEX-15DCD-0011-R1b-SM-6LPIJ
70-79 years, female
190.4
GTEX-NPJ7-0011-R1a-SM-3GACT
60-69 years, female
189.3
GTEX-1LG7Y-0011-R1a-SM-EYYWV
50-59 years, male
185.1
GTEX-1313W-0011-R1b-SM-5EQ4A
50-59 years, female
182.9
GTEX-15ER7-0011-R1b-SM-7KUE1
20-29 years, female
182.7
GTEX-ZAB4-0011-R1a-SM-4RGNO
40-49 years, male
181.6
GTEX-1EKGG-0011-R1b-SM-9QEI1
60-69 years, male
181.2
GTEX-11ONC-0011-R1a-SM-57WD4
60-69 years, male
181.1
GTEX-1GN73-0011-R1a-SM-CKZNT
60-69 years, male
180.8
GTEX-13PDP-0011-R1a-SM-5PNX5
60-69 years, male
180.1
GTEX-13OW6-0011-R1a-SM-5L3HQ
50-59 years, male
178.5
GTEX-1B8L1-0011-R1a-SM-7P8SS
60-69 years, male
177.8
GTEX-13N1W-0011-R1b-SM-5MR4T
70-79 years, male
174.8
GTEX-13OW7-0011-R1b-SM-5L3HF
50-59 years, male
174.7
GTEX-16XZZ-0011-R1a-SM-7LTAH
60-69 years, male
171.7
GTEX-11EI6-0011-R1a-SM-DO93L
60-69 years, male
167.1
GTEX-11DXW-0011-R1a-SM-DNZZD
40-49 years, male
166.6
GTEX-14PN4-0011-R1b-SM-69LP8
50-59 years, male
162.3
GTEX-1H3VE-0011-R1a-SM-A9G1K
40-49 years, male
158.1
GTEX-1HSMO-0011-R1a-SM-CM2SV
60-69 years, male
155.0
GTEX-13CF2-0011-R1a-SM-5LZY1
60-69 years, male
153.7
GTEX-WVLH-0011-R1A-SM-4MVOK
50-59 years, male
153.7
GTEX-17HHY-0011-R1a-SM-7189V
50-59 years, male
153.6
GTEX-1H3O1-0011-R1b-SM-CL554
60-69 years, male
152.4
GTEX-P44H-0011-R1A-SM-3NM8J
40-49 years, male
149.3
GTEX-1B933-0011-R1b-SM-9QEGW
50-59 years, female
148.1
GTEX-13OVJ-0011-R1b-SM-5L3I6
50-59 years, female
146.7
GTEX-1A8G6-0011-R1a-SM-7P8PC
60-69 years, male
146.7
GTEX-QVJO-0011-R1A-SM-2S1QI
60-69 years, female
138.5
GTEX-X4XX-0011-R1B-SM-3P622
60-69 years, male
134.5
GTEX-1GN2E-0011-R1b-SM-CE6RJ
60-69 years, male
131.9
GTEX-QMR6-0011-R1A-SM-32PKW
50-59 years, male
131.1
GTEX-12WSH-0011-R1a-SM-5GU5V
50-59 years, male
127.9
GTEX-PWO3-0011-R1A-SM-2I5EW
60-69 years, female
127.0
GTEX-13N2G-0011-R1b-SM-5MR3G
60-69 years, male
126.6
GTEX-15CHQ-0011-R1a-SM-COH27
60-69 years, male
120.5
GTEX-1B996-0011-R1b-SM-7P8PO
60-69 years, male
119.7
GTEX-1HBPI-0011-R1b-SM-A9SKF
50-59 years, male
115.5
GTEX-13SLW-0011-R1a-SM-5S2W7
70-79 years, male
113.7
GTEX-WZTO-0011-R1B-SM-3NMAR
40-49 years, male
109.5
GTEX-17F97-0011-R1b-SM-7IGM9
50-59 years, male
109.3
GTEX-17EVP-0011-R1a-SM-7DHLA
40-49 years, male
108.2
GTEX-12ZZX-0011-R1a-SM-5EQ6B
40-49 years, female
104.6
GTEX-13FTY-0011-R1a-SM-5LZXE
40-49 years, female
103.2
GTEX-ZE7O-0011-R1a-SM-57WDM
50-59 years, female
100.5
GTEX-14PJM-0011-R1a-SM-CNPO3
50-59 years, female
99.7
GTEX-1399T-0011-R1b-SM-5DUWN
60-69 years, male
99.4
GTEX-13RTL-0011-R1a-SM-5PNZ8
40-49 years, male
99.0
GTEX-1I1GQ-0011-R1a-SM-CY8GG
50-59 years, male
97.6
GTEX-17JCI-0011-R1b-SM-718A3
60-69 years, female
96.1
GTEX-1J8Q2-0011-R1a-SM-D4P2D
60-69 years, male
95.5
GTEX-ZF28-0011-R1a-SM-4WWD1
60-69 years, male
94.4
GTEX-OHPN-0011-R1A-SM-2I5GB
60-69 years, female
92.6
GTEX-1HR98-0011-R1a-SM-ARZLQ
60-69 years, male
92.0
GTEX-ZVZQ-0011-R1a-SM-57WBU
60-69 years, female
91.7
GTEX-1EH9U-0011-R1b-SM-CJI2B
60-69 years, male
90.3
GTEX-132Q8-0011-R1a-SM-5EGLK
60-69 years, male
89.8
GTEX-13FHP-0011-R1b-SM-5K7XL
50-59 years, male
88.6
GTEX-145LU-0011-R1a-SM-5Q5CE
50-59 years, male
87.5
GTEX-145LS-0011-R1b-SM-5PNUP
60-69 years, female
85.3
GTEX-1C64N-0011-R1b-SM-7P8Q7
50-59 years, male
85.2
GTEX-13S7M-0011-R1b-SM-5PNZE
60-69 years, female
83.6
GTEX-ZUA1-0011-R1a-SM-4YCE2
40-49 years, male
83.3
GTEX-17HII-0011-R1b-SM-7MGVW
50-59 years, male
78.7
GTEX-NPJ8-0011-R1a-SM-33HCB
40-49 years, male
75.6
GTEX-1A32A-0011-R1a-SM-7P8SQ
50-59 years, female
74.9
GTEX-1H1DG-0011-R1b-SM-CKZP1
70-79 years, male
72.6
GTEX-144GO-0011-R1a-SM-5PNWO
60-69 years, male
70.0
GTEX-1F6IF-0011-R1b-SM-9WG78
60-69 years, male
69.6
GTEX-1HGF4-0011-R1a-SM-CJI3S
60-69 years, male
68.3
GTEX-1F75W-0011-R1a-SM-ARU81
60-69 years, male
65.7
GTEX-131YS-0011-R1a-SM-5DUXC
60-69 years, female
65.4
GTEX-1GZHY-0011-R1a-SM-CE6RR
50-59 years, female
61.6
GTEX-13FHO-0011-R1b-SM-5KLZG
60-69 years, male
60.6
GTEX-14PJO-0011-R1b-SM-6AJAK
60-69 years, male
55.3
GTEX-1LB8K-0011-R1b-SM-EZ6MV
50-59 years, male
55.2
GTEX-1GF9V-0011-R1a-SM-CKZNQ
60-69 years, male
54.2
GTEX-1CAV2-0011-R1a-SM-ARZML
40-49 years, female
52.5
GTEX-1H1CY-0011-R1a-SM-CKZOZ
60-69 years, female
49.9
GTEX-13NYS-0011-R1b-SM-5MR55
60-69 years, male
49.3
GTEX-QVUS-0011-R1A-SM-3GAD2
60-69 years, female
48.7
GTEX-17MF6-0011-R1a-SM-72D6O
40-49 years, male
48.6
GTEX-UTHO-0011-R1A-SM-3GIJO
60-69 years, male
48.3
GTEX-14LZ3-0011-R1a-SM-69LP5
60-69 years, female
47.2
GTEX-11WQC-0011-R1b-SM-DO932
60-69 years, male
47.1
GTEX-11UD1-0011-R1b-SM-5BC7D
40-49 years, female
46.9
GTEX-13OVL-0011-R1a-SM-5L3H5
50-59 years, male
44.7
GTEX-13NZ8-0011-R1b-SM-5KM3V
60-69 years, female
44.2
GTEX-13RTJ-0011-R1a-SM-5O9D9
60-69 years, male
42.6
GTEX-14PQA-0011-R1b-SM-6EU1G
50-59 years, female
39.6
GTEX-183WM-0011-R1a-SM-718A8
70-79 years, female
39.5
GTEX-1E2YA-0011-R1b-SM-CJI29
50-59 years, male
39.0
GTEX-16NPV-0011-R1b-SM-7MGVZ
50-59 years, female
36.6
GTEX-1C6VQ-0011-R1a-SM-7P8Q2
50-59 years, male
36.2
GTEX-14E7W-0011-R1b-SM-5YYAT
70-79 years, male
33.7
GTEX-11GSO-0011-R1b-SM-57WD3
60-69 years, male
31.5
GTEX-13OW8-0011-R1a-SM-5L3HI
60-69 years, male
30.4
GTEX-15UF6-0011-R1a-SM-9QEGH
70-79 years, female
29.6
GTEX-13QJC-0011-R1b-SM-5S2UU
60-69 years, female
28.8
GTEX-1BAJH-0011-R1a-SM-7P8SV
70-79 years, male
23.6
GTEX-1H4P4-0011-R1b-SM-CL54V
50-59 years, male
22.1
GTEX-16GPK-0011-R1b-SM-7EWDH
60-69 years, male
21.5
GTEX-13OW5-0011-R1b-SM-5L3GE
60-69 years, male
19.4
GTEX-1212Z-0011-R1b-SM-5BC72
60-69 years, male
17.5
GTEX-11ZTS-0011-R1a-SM-5BC71
60-69 years, female
16.4
GTEX-1H23P-0011-R1a-SM-ACKVC
60-69 years, male
15.5
GTEX-XMD1-0011-R1A-SM-4AT4C
60-69 years, male
15.2
GTEX-1I1GV-0011-R1a-SM-CL559
60-69 years, male
14.2
GTEX-17EVQ-0011-R1a-SM-7189S
70-79 years, male
13.3
GTEX-13QIC-0011-R1a-SM-5O9CJ
60-69 years, female
11.7
GTEX-13JVG-0011-R1a-SM-5KM32
60-69 years, male
11.6
GTEX-13NZA-0011-R1b-SM-5LUAF
60-69 years, male
11.4
GTEX-X4EP-0011-R1A-SM-3P624
60-69 years, female
11.4
GTEX-11ZVC-0011-R1b-SM-5BC6M
50-59 years, female
10.5
GTEX-11TUW-0011-R1a-SM-DO92S
60-69 years, male
8.1
GTEX-18A6Q-0011-R1b-SM-731DI
60-69 years, male
5.8
GTEX-1CB4J-0011-R1a-SM-9WG64
60-69 years, male
3.1
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HIPPOCAMPAL FORMATION - FANTOM5 CAGEi
RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.