Protein interactions for APPBP2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	APPBP2
Gene descriptionⁱ Full gene name according to HGNC.	Amyloid beta precursor protein binding protein 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Cancer-related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Spermatids - Flagellum assembly (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.23
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Nucleoplasm
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Spermatids - Flagellum assembly

Field

Cluster

Pathway

Number of interactions:

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
FSTL1	Physical association	High	0.79	8
RRS1	Physical association	High	0.78	3
MUL1	Physical association	High	0.76	4
AK3	Physical association	High	0.72	8
ARMCX5	Physical association	High	0.72	2
C1orf50	Physical association	High	0.72	11
C6orf226	Physical association	High	0.72	5
CLCN1	Physical association	High	0.72	3
COL24A1	Physical association	High	0.72	1
CORO2B	Physical association	High	0.72	1
FXYD7	Physical association	High	0.72	2
GCSAM	Physical association	High	0.72	4
GSTP1	Physical association	High	0.72	21
HSPA4	Physical association	High	0.72	5
KLHL35	Physical association	High	0.72	7
LANCL2	Physical association	High	0.72	3
LUC7L2	Physical association	High	0.72	16
LUZP4	Physical association	High	0.72	19
TAF11	Physical association	High	0.72	1
MLLT3	Physical association	High	0.67	9
TBL3	Physical association	High	0.67	1
WDR24	Physical association	High	0.67	6
KIF6	Physical association	High	0.62	1
NFYA	Physical association	High	0.62	9
SLC22A6	Physical association	High	0.62	1
SYT11	Physical association	High	0.62	4
AADAC	Physical association	Medium	0.56	1
ACTN1	Physical association	Medium	0.56	26
AHCY	Physical association	Medium	0.56	4
ANKRD10	Physical association	Medium	0.56	1
APP	Physical association	Medium	0.56	312
BIN2	Physical association	Medium	0.56	1
CCDC167	Physical association	Medium	0.56	32
CCNL1	Physical association	Medium	0.56	16
CDK16	Physical association	Medium	0.56	6
CSNK1G2	Physical association	Medium	0.56	4
CST2	Physical association	Medium	0.56	7
CTC1	Physical association	Medium	0.56	3
DCD	Physical association	Medium	0.56	2
DHRS2	Physical association	Medium	0.56	1
DOLK	Physical association	Medium	0.56	19
DPEP1	Physical association	Medium	0.56	2
DPYS	Physical association	Medium	0.56	9
ERO1A	Physical association	Medium	0.56	6
HGFAC	Physical association	Medium	0.56	4
HIPK4	Physical association	Medium	0.56	2
HSD3B7	Physical association	Medium	0.56	42
ITGB5	Physical association	Medium	0.56	20
KLF11	Physical association	Medium	0.56	164
LONRF3	Physical association	Medium	0.56	8
MAN2B2	Physical association	Medium	0.56	9
MCOLN1	Physical association	Medium	0.56	2
MGAT4B	Physical association	Medium	0.56	2
MSH2	Physical association	Medium	0.56	8
PNPLA5	Physical association	Medium	0.56	1
PPIL6	Physical association	Medium	0.56	4
PPP1R8	Physical association	Medium	0.56	5
PRKAA2	Physical association	Medium	0.56	78
PRKACB	Physical association	Medium	0.56	5
PSAP	Physical association	Medium	0.56	6
PYROXD2	Physical association	Medium	0.56	1
RAB7B	Physical association	Medium	0.56	1
RHEB	Physical association	Medium	0.56	10
RNF128	Physical association	Medium	0.56	4
RNF34	Physical association	Medium	0.56	8
RNGTT	Physical association	Medium	0.56	1
SELENOV	Physical association	Medium	0.56	9
SLC25A23	Physical association	Medium	0.56	1
SLC7A10	Physical association	Medium	0.56	1
SLC9A3R1	Physical association	Medium	0.56	16
SNX5	Physical association	Medium	0.56	2
SPDYE6	Physical association	Medium	0.56	4
ST8SIA5	Physical association	Medium	0.56	1
SYNRG	Physical association	Medium	0.56	1
TAFA4	Physical association	Medium	0.56	1
TCF25	Physical association	Medium	0.56	9
TNP2	Physical association	Medium	0.56	7
TRMT2A	Physical association	Medium	0.56	5
UBE2R2	Physical association	Medium	0.56	4
UGGT2	Physical association	Medium	0.56	1
WAS	Physical association	Medium	0.56	15
WFIKKN1	Physical association	Medium	0.56	2
ZC3H10	Physical association	Medium	0.56	28
ZNF747	Physical association	Medium	0.56	3
IKBKE	Physical association	Medium	0.5	19
CIBAR1	Physical association	Medium	0.49	2
GP9	Physical association	Medium	0.49	4
RASSF5	Physical association	Medium	0.49	21
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
APPBP2 is not a metabolic protein