Protein interactions for KLF11 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	KLF11
Gene descriptionⁱ Full gene name according to HGNC.	KLF transcription factor 11
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Testis - Spermatogenesis (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.31
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Nucleoplasm In addition localized to the Nuclear bodies, Focal adhesion sites, Cytosol
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Testis - Spermatogenesis

Field

Cluster

Pathway

Number of interactions:

164

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
HTT	Physical association	High	0.67	665
AK8	Physical association	Medium	0.56	20
AMBN	Physical association	Medium	0.56	5
ANXA4	Physical association	Medium	0.56	8
ANXA8	Physical association	Medium	0.56	14
APP	Physical association	Medium	0.56	312
APPBP2	Physical association	Medium	0.56	88
AQP8	Physical association	Medium	0.56	11
ARL2BP	Physical association	Medium	0.56	7
ASB13	Physical association	Medium	0.56	10
ATP5IF1	Physical association	Medium	0.56	14
ATP6V1B1	Physical association	Medium	0.56	8
BAHD1	Physical association	Medium	0.56	54
BCAS2	Physical association	Medium	0.56	49
BCHE	Physical association	Medium	0.56	5
BECN1	Physical association	Medium	0.56	48
BMF	Physical association	Medium	0.56	21
BORCS5	Physical association	Medium	0.56	2
BRAT1	Physical association	Medium	0.56	7
BRK1	Physical association	Medium	0.56	46
CABCOCO1	Physical association	Medium	0.56	2
CBX6	Physical association	Medium	0.56	7
CD248	Physical association	Medium	0.56	4
CDC23	Physical association	Medium	0.56	69
CENPV	Physical association	Medium	0.56	14
CEP55	Physical association	Medium	0.56	56
CEP70	Physical association	Medium	0.56	196
CHMP7	Physical association	Medium	0.56	15
COG8	Physical association	Medium	0.56	6
COX4I1	Physical association	Medium	0.56	3
COX7A1	Physical association	Medium	0.56	2
CRACR2A	Physical association	Medium	0.56	31
CRBN	Physical association	Medium	0.56	9
CRLF3	Physical association	Medium	0.56	24
CRYBA2	Physical association	Medium	0.56	21
CYFIP1	Physical association	Medium	0.56	10
CYRIB	Physical association	Medium	0.56	3
DBNL	Physical association	Medium	0.56	10
DDI1	Physical association	Medium	0.56	16
DELE1	Physical association	Medium	0.56	6
DKK3	Physical association	Medium	0.56	2
DPYS	Physical association	Medium	0.56	9
DPYSL5	Physical association	Medium	0.56	16
DSN1	Physical association	Medium	0.56	8
E2F8	Physical association	Medium	0.56	16
EFHC1	Physical association	Medium	0.56	61
EIF3F	Physical association	Medium	0.56	42
EIF3K	Physical association	Medium	0.56	10
EIF3L	Physical association	Medium	0.56	9
ERGIC1	Physical association	Medium	0.56	4
ESRP1	Physical association	Medium	0.56	28
FAM117B	Physical association	Medium	0.56	21
FANCG	Physical association	Medium	0.56	35
FAR1	Physical association	Medium	0.56	1
FGF21	Physical association	Medium	0.56	6
FHL5	Physical association	Medium	0.56	62
GINS3	Physical association	Medium	0.56	8
GKN1	Physical association	Medium	0.56	13
GMPPA	Physical association	Medium	0.56	10
GPM6A	Physical association	Medium	0.56	5
GPN2	Physical association	Medium	0.56	2
H2AC6	Physical association	Medium	0.56	1
H3-5	Physical association	Medium	0.56	17
HAUS1	Physical association	Medium	0.56	83
HAUS3	Physical association	Medium	0.56	8
HAUS7	Physical association	Medium	0.56	11
IGFBP1	Physical association	Medium	0.56	3
IGFBP4	Physical association	Medium	0.56	10
INCA1	Physical association	Medium	0.56	204
IQGAP3	Physical association	Medium	0.56	6
IQUB	Physical association	Medium	0.56	56
ITGB3BP	Physical association	Medium	0.56	28
KAZALD1	Physical association	Medium	0.56	1
KIAA0408	Physical association	Medium	0.56	24
KIAA0825	Physical association	Medium	0.56	3
KLC3	Physical association	Medium	0.56	30
KLF15	Physical association	Medium	0.56	30
KLF3	Physical association	Medium	0.56	28
KLF5	Physical association	Medium	0.56	6
KLHL20	Physical association	Medium	0.56	31
KLHL3	Physical association	Medium	0.56	9
KLHL32	Physical association	Medium	0.56	4
KRT222	Physical association	Medium	0.56	9
KRT33B	Physical association	Medium	0.56	65
LAPTM4A	Physical association	Medium	0.56	6
LARP4B	Physical association	Medium	0.56	16
LGALS9C	Physical association	Medium	0.56	23
LOXL4	Physical association	Medium	0.56	15
LRRC61	Physical association	Medium	0.56	12
LURAP1	Physical association	Medium	0.56	17
LZTS2	Physical association	Medium	0.56	178
MAOB	Physical association	Medium	0.56	14
MED21	Physical association	Medium	0.56	17
MESD	Physical association	Medium	0.56	51
METTL27	Physical association	Medium	0.56	41
MIS18A	Physical association	Medium	0.56	26
MRFAP1	Physical association	Medium	0.56	34
MRFAP1L1	Physical association	Medium	0.56	46
MT2A	Physical association	Medium	0.56	13
MYLIP	Physical association	Medium	0.56	29
NELFCD	Physical association	Medium	0.56	5
NEUROD1	Physical association	Medium	0.56	6
NUP54	Physical association	Medium	0.56	40
ODAD3	Physical association	Medium	0.56	16
OIP5	Physical association	Medium	0.56	113
OTUB1	Physical association	Medium	0.56	43
OTULINL	Physical association	Medium	0.56	11
PADI3	Physical association	Medium	0.56	6
PAIP2	Physical association	Medium	0.56	7
PER1	Physical association	Medium	0.56	21
PFDN5	Physical association	Medium	0.56	81
PHF23	Physical association	Medium	0.56	7
PIGP	Physical association	Medium	0.56	19
PKNOX1	Physical association	Medium	0.56	12
PMF1	Physical association	Medium	0.56	13
PRUNE2	Physical association	Medium	0.56	13
PSMC2	Physical association	Medium	0.56	13
RAP1GAP	Physical association	Medium	0.56	3
RCN1	Physical association	Medium	0.56	19
REX1BD	Physical association	Medium	0.56	13
RGS17	Physical association	Medium	0.56	34
RNF31	Physical association	Medium	0.56	11
RPS6KA2	Physical association	Medium	0.56	6
RPS6KA3	Physical association	Medium	0.56	6
SMARCD1	Physical association	Medium	0.56	104
SNF8	Physical association	Medium	0.56	19
SPATA12	Physical association	Medium	0.56	22
STAT4	Physical association	Medium	0.56	4
STK36	Physical association	Medium	0.56	7
STX11	Physical association	Medium	0.56	80
STX19	Physical association	Medium	0.56	16
STXBP1	Physical association	Medium	0.56	16
SYCE3	Physical association	Medium	0.56	10
TADA3	Physical association	Medium	0.56	13
TBL1XR1	Physical association	Medium	0.56	5
TBRG1	Physical association	Medium	0.56	4
TCAP	Physical association	Medium	0.56	34
TCP11L2	Physical association	Medium	0.56	4
TEN1	Physical association	Medium	0.56	14
TEX12	Physical association	Medium	0.56	28
THAP3	Physical association	Medium	0.56	15
TMEM174	Physical association	Medium	0.56	12
TP53BP1	Physical association	Medium	0.56	71
TSACC	Physical association	Medium	0.56	6
TSNAX	Physical association	Medium	0.56	36
TSPAN2	Physical association	Medium	0.56	34
TTC23L	Physical association	Medium	0.56	19
TTC33	Physical association	Medium	0.56	9
TXNDC9	Physical association	Medium	0.56	18
UBE2A	Physical association	Medium	0.56	17
UBQLN3	Physical association	Medium	0.56	6
UBQLNL	Physical association	Medium	0.56	8
UGP2	Physical association	Medium	0.56	4
UTP6	Physical association	Medium	0.56	3
VDAC2	Physical association	Medium	0.56	19
VIM	Physical association	Medium	0.56	86
VPS37A	Physical association	Medium	0.56	18
VSX2	Physical association	Medium	0.56	20
WDR83	Physical association	Medium	0.56	30
YRDC	Physical association	Medium	0.56	3
ZBTB14	Physical association	Medium	0.56	54
ZNF346	Physical association	Medium	0.56	9
ZWINT	Physical association	Medium	0.56	21
ZXDC	Physical association	Medium	0.56	19
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
KLF11 is not a metabolic protein