Protein interactions for HTT - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HTT
Gene descriptionⁱ Full gene name according to HGNC.	Huntingtin
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Basic cellular processes (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.27
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Nucleoplasm In addition localized to the Cytosol
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Non-specific - Basic cellular processes

Field

Cluster

Pathway

Number of interactions:

665

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
OPTN	Direct interaction	High	0.82	127
ZDHHC17	Direct interaction	High	0.81	30
HIP1	Physical association	High	0.81	48
DYNC1H1	Physical association	High	0.77	34
SH3GL3	Direct interaction	High	0.74	8
EEF1D	Physical association	High	0.74	10
DNALI1	Physical association	High	0.74	60
NUP58	Physical association	High	0.74	77
RNF20	Physical association	High	0.74	13
UBAC1	Physical association	High	0.74	24
UBE2K	Physical association	High	0.74	60
ZFYVE19	Physical association	High	0.74	5
ZNF655	Physical association	High	0.74	117
FEZ1	Physical association	High	0.72	6
TP53	Physical association	High	0.71	157
BECN1	Physical association	High	0.7	48
CRMP1	Physical association	High	0.7	10
ERCC6L	Physical association	High	0.7	3
FTL	Physical association	High	0.7	13
GOLPH3L	Physical association	High	0.7	3
H3C1	Physical association	High	0.7	52
H3C10	Physical association	High	0.7	52
H3C11	Physical association	High	0.7	52
H3C12	Physical association	High	0.7	52
H3C2	Physical association	High	0.7	52
H3C3	Physical association	High	0.7	52
H3C4	Physical association	High	0.7	52
H3C6	Physical association	High	0.7	52
H3C7	Physical association	High	0.7	52
H3C8	Physical association	High	0.7	52
MED31	Physical association	High	0.7	9
MRFAP1L1	Physical association	High	0.7	46
PFN2	Physical association	High	0.7	3
PIAS4	Physical association	High	0.7	35
XRCC6	Physical association	High	0.7	21
ZMAT2	Physical association	High	0.7	44
ARFGAP3	Physical association	High	0.68	29
HNRNPC	Physical association	High	0.68	25
MEOX1	Physical association	High	0.68	78
NME4	Physical association	High	0.68	43
RPL4	Physical association	High	0.68	8
SIN3A	Physical association	High	0.68	11
ACTG1	Physical association	High	0.67	14
BCAP31	Physical association	High	0.67	12
CCT6A	Physical association	High	0.67	9
CCT8	Physical association	High	0.67	8
CD59	Physical association	High	0.67	3
CETN2	Physical association	High	0.67	7
CHCHD2	Physical association	High	0.67	24
CNOT10	Physical association	High	0.67	6
CNOT7	Physical association	High	0.67	15
CNP	Physical association	High	0.67	1
COPS3	Physical association	High	0.67	42
COX5B	Physical association	High	0.67	29
COX6A1	Physical association	High	0.67	2
COX6C	Physical association	High	0.67	4
CYC1	Physical association	High	0.67	2
DCAF7	Physical association	High	0.67	42
DNAJA1	Physical association	High	0.67	3
DYNLL1	Physical association	High	0.67	59
EEF1B2	Physical association	High	0.67	4
EIF3G	Physical association	High	0.67	12
EIF3I	Physical association	High	0.67	8
EIF4E2	Physical association	High	0.67	32
ENO1	Physical association	High	0.67	4
FASN	Physical association	High	0.67	5
FLOT1	Physical association	High	0.67	9
G3BP1	Physical association	High	0.67	17
GFAP	Physical association	High	0.67	147
GNAO1	Physical association	High	0.67	8
GNB1	Physical association	High	0.67	7
GNB2	Physical association	High	0.67	26
GPM6A	Physical association	High	0.67	5
HSPA8	Physical association	High	0.67	35
IMMT	Physical association	High	0.67	11
IPO4	Physical association	High	0.67	6
LANCL1	Physical association	High	0.67	2
MATR3	Physical association	High	0.67	14
NDUFA13	Physical association	High	0.67	3
NDUFA9	Physical association	High	0.67	9
NDUFB10	Physical association	High	0.67	6
NDUFB9	Physical association	High	0.67	2
NDUFS5	Physical association	High	0.67	4
PLEC	Physical association	High	0.67	5
PPIH	Physical association	High	0.67	11
PPP1CA	Physical association	High	0.67	87
PRNP	Physical association	High	0.67	17
PRRC1	Physical association	High	0.67	3
PSMA4	Physical association	High	0.67	13
PSMA6	Physical association	High	0.67	23
PSMA7	Physical association	High	0.67	16
PSMB1	Physical association	High	0.67	83
PSMB2	Physical association	High	0.67	14
PSMD14	Physical association	High	0.67	18
PSMD7	Physical association	High	0.67	19
RAE1	Physical association	High	0.67	5
RANGAP1	Physical association	High	0.67	7
RPL13	Physical association	High	0.67	7
SKIC8	Physical association	High	0.67	30
ST13	Physical association	High	0.67	5
STRAP	Physical association	High	0.67	4
STXBP1	Physical association	High	0.67	16
SYP	Physical association	High	0.67	29
SYT2	Physical association	High	0.67	24
UFD1	Physical association	High	0.67	4
VCP	Physical association	High	0.67	48
VDAC2	Physical association	High	0.67	19
VIM	Physical association	High	0.67	86
VPS28	Physical association	High	0.67	12
CHMP4B	Physical association	High	0.67	14
COPB1	Physical association	High	0.67	10
CTNNB1	Physical association	High	0.67	81
CUL5	Physical association	High	0.67	17
DCTN2	Physical association	High	0.67	35
DNAJA3	Physical association	High	0.67	9
DNAJC4	Physical association	High	0.67	3
EZR	Physical association	High	0.67	17
GAPDH	Physical association	High	0.67	28
GPRASP2	Physical association	High	0.67	23
GTF3C3	Physical association	High	0.67	41
H2AP	Physical association	High	0.67	15
HAX1	Physical association	High	0.67	11
HOXC11	Physical association	High	0.67	4
HOXC4	Physical association	High	0.67	22
HYPK	Physical association	High	0.67	5
JAKMIP1	Physical association	High	0.67	14
KLF11	Physical association	High	0.67	164
KPNA3	Physical association	High	0.67	32
MAGEB18	Physical association	High	0.67	10
MKRN2	Physical association	High	0.67	9
MRFAP1	Physical association	High	0.67	34
PDK2	Physical association	High	0.67	1
PIAS1	Physical association	High	0.67	38
PIK3R3	Physical association	High	0.67	70
PKM	Physical association	High	0.67	11
PPARG	Physical association	High	0.67	12
PPL	Physical association	High	0.67	31
PSMD4	Physical association	High	0.67	24
PTK6	Physical association	High	0.67	22
RNF40	Physical association	High	0.67	8
SP3	Physical association	High	0.67	8
TXNDC11	Physical association	High	0.67	7
UTP14A	Physical association	High	0.67	15
WDR91	Physical association	High	0.67	2
YWHAB	Physical association	High	0.67	78
ZBTB16	Physical association	High	0.67	43
SQSTM1	Physical association	High	0.65	36
ULK1	Physical association	High	0.61	19
GIT1	Physical association	High	0.6	17
PACSIN1	Direct interaction	Medium	0.59	13
WDFY3	Physical association	Medium	0.58	10
CREBBP	Physical association	Medium	0.57	36
AAMDC	Physical association	Medium	0.56	6
ABHD17C	Physical association	Medium	0.56	11
ABT1	Physical association	Medium	0.56	13
ACTB	Physical association	Medium	0.56	25
ACTR1B	Physical association	Medium	0.56	3
ADIPOQ	Physical association	Medium	0.56	46
AFG3L2	Physical association	Medium	0.56	1
AGK	Physical association	Medium	0.56	1
AHDC1	Physical association	Medium	0.56	2
AK3	Physical association	Medium	0.56	8
AKR1A1	Physical association	Medium	0.56	3
AKT1	Physical association	Medium	0.56	58
ALDH1L2	Physical association	Medium	0.56	1
ALG2	Physical association	Medium	0.56	2
AOC3	Physical association	Medium	0.56	10
AP3B1	Physical association	Medium	0.56	5
AP3M1	Physical association	Medium	0.56	10
APP	Physical association	Medium	0.56	312
ARCN1	Physical association	Medium	0.56	2
ARFIP2	Physical association	Medium	0.56	42
ARMCX5	Physical association	Medium	0.56	2
ASCL4	Physical association	Medium	0.56	34
ATG4C	Physical association	Medium	0.56	1
ATL1	Physical association	Medium	0.56	17
ATP5F1A	Physical association	Medium	0.56	8
ATP5PB	Physical association	Medium	0.56	12
ATP5PO	Physical association	Medium	0.56	18
ATP6AP1	Physical association	Medium	0.56	1
ATP6V0D1	Physical association	Medium	0.56	6
ATP6V1B2	Physical association	Medium	0.56	7
ATP6V1H	Physical association	Medium	0.56	5
BATF	Physical association	Medium	0.56	18
BBLN	Physical association	Medium	0.56	7
BEX3	Physical association	Medium	0.56	25
BIRC5	Physical association	Medium	0.56	22
BRK1	Physical association	Medium	0.56	46
C15orf48	Physical association	Medium	0.56	1
C1D	Physical association	Medium	0.56	11
C1orf94	Physical association	Medium	0.56	69
C1QTNF3	Physical association	Medium	0.56	1
C20orf141	Physical association	Medium	0.56	4
C7orf31	Physical association	Medium	0.56	15
C7orf50	Physical association	Medium	0.56	4
CABCOCO1	Physical association	Medium	0.56	2
CAMK1	Physical association	Medium	0.56	3
CAPN10	Physical association	Medium	0.56	6
CASP3	Physical association	Medium	0.56	16
CASP6	Physical association	Medium	0.56	122
CASP7	Physical association	Medium	0.56	10
CBL	Physical association	Medium	0.56	34
CBS	Physical association	Medium	0.56	17
CBX1	Physical association	Medium	0.56	26
CCDC120	Physical association	Medium	0.56	90
CCDC9	Physical association	Medium	0.56	4
CCIN	Physical association	Medium	0.56	2
CCNB1IP1	Physical association	Medium	0.56	11
CCNC	Physical association	Medium	0.56	69
CCNE2	Physical association	Medium	0.56	6
CCNG1	Physical association	Medium	0.56	14
CCT2	Physical association	Medium	0.56	11
CCT5	Physical association	Medium	0.56	28
CDC42EP4	Physical association	Medium	0.56	2
CDC5L	Physical association	Medium	0.56	48
CDC7	Physical association	Medium	0.56	21
CDCA7	Physical association	Medium	0.56	2
CDH13	Physical association	Medium	0.56	2
CDS2	Physical association	Medium	0.56	29
CENPS	Physical association	Medium	0.56	5
CENPV	Physical association	Medium	0.56	14
CEP55	Physical association	Medium	0.56	56
CHCHD3	Physical association	Medium	0.56	37
CHMP1A	Physical association	Medium	0.56	14
CHMP2A	Physical association	Medium	0.56	5
CIDEB	Physical association	Medium	0.56	58
CKM	Physical association	Medium	0.56	4
CLEC11A	Physical association	Medium	0.56	6
CLEC2B	Physical association	Medium	0.56	2
CLPP	Physical association	Medium	0.56	19
CLRN3	Physical association	Medium	0.56	1
COG8	Physical association	Medium	0.56	6
CPSF3	Physical association	Medium	0.56	3
CRACR2A	Physical association	Medium	0.56	31
CREB1	Physical association	Medium	0.56	15
CRK	Physical association	Medium	0.56	54
CRYAA	Physical association	Medium	0.56	72
CRYBA2	Physical association	Medium	0.56	21
CSF2	Physical association	Medium	0.56	4
CSRP3	Physical association	Medium	0.56	3
CUL3	Physical association	Medium	0.56	36
CXorf38	Physical association	Medium	0.56	10
CYP3A5	Physical association	Medium	0.56	1
DAPP1	Physical association	Medium	0.56	9
DAXX	Physical association	Medium	0.56	78
DAZAP2	Physical association	Medium	0.56	124
DBNL	Physical association	Medium	0.56	10
DCLRE1B	Physical association	Medium	0.56	8
DCTN4	Physical association	Medium	0.56	8
DDX20	Physical association	Medium	0.56	9
DDX21	Physical association	Medium	0.56	10
DDX39A	Physical association	Medium	0.56	9
DDX41	Physical association	Medium	0.56	8
DELE1	Physical association	Medium	0.56	6
DENND2B	Physical association	Medium	0.56	2
DES	Physical association	Medium	0.56	36
DEUP1	Physical association	Medium	0.56	34
DLD	Physical association	Medium	0.56	6
DLST	Physical association	Medium	0.56	55
DLX3	Physical association	Medium	0.56	7
DNAJB4	Physical association	Medium	0.56	4
DNTTIP1	Physical association	Medium	0.56	11
DPAGT1	Physical association	Medium	0.56	1
DPYSL2	Physical association	Medium	0.56	7
DPYSL5	Physical association	Medium	0.56	16
E2F8	Physical association	Medium	0.56	16
EDF1	Physical association	Medium	0.56	6
EDRF1	Physical association	Medium	0.56	6
EEF1A2	Physical association	Medium	0.56	6
EEF2	Physical association	Medium	0.56	3
EFEMP1	Physical association	Medium	0.56	27
EIF1AY	Physical association	Medium	0.56	2
EIF2S2	Physical association	Medium	0.56	13
EIF2S3	Physical association	Medium	0.56	15
EIF5	Physical association	Medium	0.56	3
ENKUR	Physical association	Medium	0.56	9
ENTPD2	Physical association	Medium	0.56	2
ENTPD5	Physical association	Medium	0.56	2
ERICH2	Physical association	Medium	0.56	4
ERP27	Physical association	Medium	0.56	10
EXOC5	Physical association	Medium	0.56	46
EYA3	Physical association	Medium	0.56	8
F8A1	Physical association	Medium	0.56	1
F8A2	Physical association	Medium	0.56	1
F8A3	Physical association	Medium	0.56	1
FAM111B	Physical association	Medium	0.56	4
FAM163A	Physical association	Medium	0.56	17
FAM167A	Physical association	Medium	0.56	7
FAM78A	Physical association	Medium	0.56	2
FAM9A	Physical association	Medium	0.56	47
FANCF	Physical association	Medium	0.56	3
FANK1	Physical association	Medium	0.56	5
FARSB	Physical association	Medium	0.56	3
FASTKD1	Physical association	Medium	0.56	9
FBH1	Physical association	Medium	0.56	3
FBP1	Physical association	Medium	0.56	6
FEZ2	Physical association	Medium	0.56	12
FHL3	Physical association	Medium	0.56	103
FICD	Physical association	Medium	0.56	1
FKBP2	Physical association	Medium	0.56	5
FOXD4L6	Physical association	Medium	0.56	15
FOXR1	Physical association	Medium	0.56	14
FZD4	Physical association	Medium	0.56	4
G2E3	Physical association	Medium	0.56	6
GAB2	Physical association	Medium	0.56	9
GALNT4	Physical association	Medium	0.56	1
GCA	Physical association	Medium	0.56	9
GFOD1	Physical association	Medium	0.56	17
GIMAP2	Physical association	Medium	0.56	1
GLIPR1	Physical association	Medium	0.56	1
GOLGA2	Physical association	Medium	0.56	349
GPIHBP1	Physical association	Medium	0.56	2
GPR141	Physical association	Medium	0.56	8
GPX7	Physical association	Medium	0.56	10
GRAP	Physical association	Medium	0.56	5
GSK3A	Physical association	Medium	0.56	12
GTPBP4	Physical association	Medium	0.56	3
H2BC9	Physical association	Medium	0.56	2
H3-5	Physical association	Medium	0.56	17
H3C13	Physical association	Medium	0.56	27
H3C14	Physical association	Medium	0.56	27
H3C15	Physical association	Medium	0.56	27
H4C1	Physical association	Medium	0.56	54
H4C11	Physical association	Medium	0.56	54
H4C12	Physical association	Medium	0.56	54
H4C13	Physical association	Medium	0.56	54
H4C14	Physical association	Medium	0.56	54
H4C15	Physical association	Medium	0.56	54
H4C16	Physical association	Medium	0.56	54
H4C2	Physical association	Medium	0.56	54
H4C3	Physical association	Medium	0.56	54
H4C4	Physical association	Medium	0.56	54
H4C5	Physical association	Medium	0.56	54
H4C6	Physical association	Medium	0.56	54
H4C8	Physical association	Medium	0.56	54
H4C9	Physical association	Medium	0.56	54
HADHA	Physical association	Medium	0.56	8
HAUS7	Physical association	Medium	0.56	11
HDAC10	Physical association	Medium	0.56	6
HDAC6	Physical association	Medium	0.56	19
HES4	Physical association	Medium	0.56	6
HIRIP3	Physical association	Medium	0.56	1
HK3	Physical association	Medium	0.56	6
HMBS	Physical association	Medium	0.56	2
HMG20B	Physical association	Medium	0.56	16
HNRNPK	Physical association	Medium	0.56	49
HOXA5	Physical association	Medium	0.56	4
HPRT1	Physical association	Medium	0.56	10
HSPA1A	Physical association	Medium	0.56	7
HSPA2	Physical association	Medium	0.56	38
HYAL2	Physical association	Medium	0.56	12
ID2	Physical association	Medium	0.56	20
IFT57	Physical association	Medium	0.56	18
IGFBP4	Physical association	Medium	0.56	10
ING4	Physical association	Medium	0.56	11
INO80E	Physical association	Medium	0.56	19
KAT5	Physical association	Medium	0.56	180
KCNAB2	Physical association	Medium	0.56	2
KCNMB2	Physical association	Medium	0.56	2
KCTD17	Physical association	Medium	0.56	29
KIAA0408	Physical association	Medium	0.56	24
KLF12	Physical association	Medium	0.56	9
KLF3	Physical association	Medium	0.56	28
KLHL12	Physical association	Medium	0.56	40
KLHL20	Physical association	Medium	0.56	31
KLK8	Physical association	Medium	0.56	13
KNSTRN	Physical association	Medium	0.56	8
KRT18	Physical association	Medium	0.56	26
KRT19	Physical association	Medium	0.56	65
KRT20	Physical association	Medium	0.56	32
KRT33B	Physical association	Medium	0.56	65
KRTAP10-7	Physical association	Medium	0.56	239
KRTAP11-1	Physical association	Medium	0.56	83
KRTAP8-1	Physical association	Medium	0.56	76
KRTAP9-2	Physical association	Medium	0.56	123
LARP4B	Physical association	Medium	0.56	16
LCA5L	Physical association	Medium	0.56	14
LCE1B	Physical association	Medium	0.56	69
LDHAL6B	Physical association	Medium	0.56	17
LDHB	Physical association	Medium	0.56	7
LGALS14	Physical association	Medium	0.56	43
LHX5	Physical association	Medium	0.56	17
LHX6	Physical association	Medium	0.56	18
LHX8	Physical association	Medium	0.56	28
LIN28A	Physical association	Medium	0.56	3
LMAN2L	Physical association	Medium	0.56	2
LNX1	Physical association	Medium	0.56	333
LNX2	Physical association	Medium	0.56	63
LONRF2	Physical association	Medium	0.56	12
LPIN1	Physical association	Medium	0.56	18
LRRC45	Physical association	Medium	0.56	6
LRRFIP1	Physical association	Medium	0.56	2
LSM8	Physical association	Medium	0.56	12
LUC7L2	Physical association	Medium	0.56	16
LYG1	Physical association	Medium	0.56	3
MAF1	Physical association	Medium	0.56	4
MAGEA3	Physical association	Medium	0.56	12
MALSU1	Physical association	Medium	0.56	10
MAP3K5	Physical association	Medium	0.56	30
MAT1A	Physical association	Medium	0.56	3
MCRS1	Physical association	Medium	0.56	97
MEAF6	Physical association	Medium	0.56	10
MECP2	Physical association	Medium	0.56	33
MED28	Physical association	Medium	0.56	18
MED30	Physical association	Medium	0.56	8
METTL27	Physical association	Medium	0.56	41
MGARP	Physical association	Medium	0.56	14
MICAL2	Physical association	Medium	0.56	8
MKNK1	Physical association	Medium	0.56	6
MMUT	Physical association	Medium	0.56	2
MNAT1	Physical association	Medium	0.56	5
MNDA	Physical association	Medium	0.56	11
MORF4L2	Physical association	Medium	0.56	42
MPND	Physical association	Medium	0.56	15
MRPL13	Physical association	Medium	0.56	1
MSRB2	Physical association	Medium	0.56	9
MSX2	Physical association	Medium	0.56	26
MT2A	Physical association	Medium	0.56	13
NACAD	Physical association	Medium	0.56	2
NAP1L2	Physical association	Medium	0.56	13
NAPA	Physical association	Medium	0.56	5
NCF1	Physical association	Medium	0.56	13
NCLN	Physical association	Medium	0.56	2
NDN	Physical association	Medium	0.56	11
NEBL	Physical association	Medium	0.56	28
NEK8	Physical association	Medium	0.56	12
NEUROD1	Physical association	Medium	0.56	6
NGEF	Physical association	Medium	0.56	8
NHP2	Physical association	Medium	0.56	3
NLK	Physical association	Medium	0.56	11
NME5	Physical association	Medium	0.56	5
NOD1	Physical association	Medium	0.56	11
NR2C2AP	Physical association	Medium	0.56	8
NUDT4	Physical association	Medium	0.56	4
NUFIP2	Physical association	Medium	0.56	58
OGDH	Physical association	Medium	0.56	2
OOSP2	Physical association	Medium	0.56	2
OTOGL	Physical association	Medium	0.56	1
PACS1	Physical association	Medium	0.56	8
PAK5	Physical association	Medium	0.56	30
PALMD	Physical association	Medium	0.56	2
PALS1	Physical association	Medium	0.56	19
PAQR7	Physical association	Medium	0.56	4
PARK7	Physical association	Medium	0.56	21
PBX4	Physical association	Medium	0.56	60
PDLIM5	Physical association	Medium	0.56	9
PDZK1IP1	Physical association	Medium	0.56	71
PELI1	Physical association	Medium	0.56	15
PELO	Physical association	Medium	0.56	20
PES1	Physical association	Medium	0.56	4
PFDN5	Physical association	Medium	0.56	81
PICK1	Physical association	Medium	0.56	275
PIH1D2	Physical association	Medium	0.56	64
PIK3CA	Physical association	Medium	0.56	10
PINK1	Physical association	Medium	0.56	14
PIWIL1	Physical association	Medium	0.56	5
PLA2G4C	Physical association	Medium	0.56	1
PLEKHG7	Physical association	Medium	0.56	18
POC1A	Physical association	Medium	0.56	8
PPARA	Physical association	Medium	0.56	18
PPP1R16B	Physical association	Medium	0.56	31
PPP2R5E	Physical association	Medium	0.56	8
PQBP1	Physical association	Medium	0.56	9
PRIM1	Physical association	Medium	0.56	2
PRKACA	Physical association	Medium	0.56	41
PRPF31	Physical association	Medium	0.56	118
PRUNE2	Physical association	Medium	0.56	13
PSMA1	Physical association	Medium	0.56	135
PSMB3	Physical association	Medium	0.56	15
PSMB6	Physical association	Medium	0.56	7
PSMC3	Physical association	Medium	0.56	20
PSMD3	Physical association	Medium	0.56	11
PTGDS	Physical association	Medium	0.56	10
QARS1	Physical association	Medium	0.56	53
RAB35	Physical association	Medium	0.56	3
RAB5B	Physical association	Medium	0.56	4
RAD23A	Physical association	Medium	0.56	41
RAN	Physical association	Medium	0.56	86
RAPGEF4	Physical association	Medium	0.56	6
RASA1	Physical association	Medium	0.56	8
RASL11A	Physical association	Medium	0.56	1
RASSF2	Physical association	Medium	0.56	15
RBM11	Physical association	Medium	0.56	24
RBM5	Physical association	Medium	0.56	12
RCAN3	Physical association	Medium	0.56	4
RCN1	Physical association	Medium	0.56	19
REXO4	Physical association	Medium	0.56	3
RIMKLA	Physical association	Medium	0.56	4
RINT1	Physical association	Medium	0.56	68
RIPPLY2	Physical association	Medium	0.56	9
RNF112	Physical association	Medium	0.56	18
RNF183	Physical association	Medium	0.56	30
RPL15	Physical association	Medium	0.56	6
RPL18	Physical association	Medium	0.56	5
RPL19	Physical association	Medium	0.56	5
RPL22	Physical association	Medium	0.56	16
RPL26L1	Physical association	Medium	0.56	2
RPL27	Physical association	Medium	0.56	5
RPL31	Physical association	Medium	0.56	5
RPS12	Physical association	Medium	0.56	3
RPS15A	Physical association	Medium	0.56	8
RPS19	Physical association	Medium	0.56	6
RPS27A	Physical association	Medium	0.56	15
RPS3	Physical association	Medium	0.56	14
RPS5	Physical association	Medium	0.56	4
RUFY4	Physical association	Medium	0.56	9
RUSF1	Physical association	Medium	0.56	49
RXRG	Physical association	Medium	0.56	13
RYBP	Physical association	Medium	0.56	44
S100P	Physical association	Medium	0.56	15
SAP30	Physical association	Medium	0.56	8
SASS6	Physical association	Medium	0.56	4
SCFD1	Physical association	Medium	0.56	1
SDCBP	Physical association	Medium	0.56	240
SEC23B	Physical association	Medium	0.56	12
SECISBP2	Physical association	Medium	0.56	2
SEPTIN4	Physical association	Medium	0.56	6
SEPTIN6	Physical association	Medium	0.56	17
SERTAD1	Physical association	Medium	0.56	20
SF3A3	Physical association	Medium	0.56	7
SF3B3	Physical association	Medium	0.56	9
SFXN3	Physical association	Medium	0.56	16
SH3GL1	Physical association	Medium	0.56	21
SH3GLB2	Physical association	Medium	0.56	19
SHLD1	Physical association	Medium	0.56	6
SLC1A2	Physical association	Medium	0.56	1
SLC25A11	Physical association	Medium	0.56	7
SLC44A5	Physical association	Medium	0.56	8
SMARCB1	Physical association	Medium	0.56	33
SMARCD1	Physical association	Medium	0.56	104
SNAP29	Physical association	Medium	0.56	25
SNRPD2	Physical association	Medium	0.56	14
SNRPF	Physical association	Medium	0.56	20
SNW1	Physical association	Medium	0.56	89
SNX12	Physical association	Medium	0.56	8
SNX2	Physical association	Medium	0.56	16
SNX33	Physical association	Medium	0.56	12
SOCS4	Physical association	Medium	0.56	14
SOX14	Physical association	Medium	0.56	13
SOX7	Physical association	Medium	0.56	3
SP6	Physical association	Medium	0.56	9
SPANXC	Physical association	Medium	0.56	2
SPATA12	Physical association	Medium	0.56	22
SPATA22	Physical association	Medium	0.56	16
SPATA2L	Physical association	Medium	0.56	16
SPCS3	Physical association	Medium	0.56	4
SPIB	Physical association	Medium	0.56	1
SPINK13	Physical association	Medium	0.56	1
SPRED2	Physical association	Medium	0.56	38
SREBF1	Physical association	Medium	0.56	2
SSB	Physical association	Medium	0.56	6
SSU72	Physical association	Medium	0.56	3
STAM2	Physical association	Medium	0.56	31
STAR	Physical association	Medium	0.56	6
STN1	Physical association	Medium	0.56	16
STUB1	Physical association	Medium	0.56	54
SUMF2	Physical association	Medium	0.56	8
SUMO1	Physical association	Medium	0.56	59
SUMO3	Physical association	Medium	0.56	13
SYCE3	Physical association	Medium	0.56	10
SYMPK	Physical association	Medium	0.56	3
SYT3	Physical association	Medium	0.56	7
TAGLN2	Physical association	Medium	0.56	4
TALDO1	Physical association	Medium	0.56	2
TAOK3	Physical association	Medium	0.56	3
TASOR2	Physical association	Medium	0.56	34
TBC1D5	Physical association	Medium	0.56	10
TBR1	Physical association	Medium	0.56	7
TBX22	Physical association	Medium	0.56	10
TCP1	Physical association	Medium	0.56	11
TCP10L	Physical association	Medium	0.56	28
TEN1	Physical association	Medium	0.56	14
TENT5B	Physical association	Medium	0.56	57
TEX55	Physical association	Medium	0.56	1
TFF2	Physical association	Medium	0.56	8
TFG	Physical association	Medium	0.56	45
TGDS	Physical association	Medium	0.56	1
TGFBR2	Physical association	Medium	0.56	54
TIGD1	Physical association	Medium	0.56	1
TIMM8A	Physical association	Medium	0.56	13
TLE5	Physical association	Medium	0.56	105
TMA16	Physical association	Medium	0.56	6
TMEM106B	Physical association	Medium	0.56	2
TMEM115	Physical association	Medium	0.56	11
TMEM205	Physical association	Medium	0.56	15
TMEM43	Physical association	Medium	0.56	13
TMEM47	Physical association	Medium	0.56	5
TNFAIP1	Physical association	Medium	0.56	31
TNFRSF11B	Physical association	Medium	0.56	3
TNFSF15	Physical association	Medium	0.56	2
TNIP3	Physical association	Medium	0.56	26
TOMM22	Physical association	Medium	0.56	5
TPI1	Physical association	Medium	0.56	4
TRAF2	Physical association	Medium	0.56	237
TRIM21	Physical association	Medium	0.56	24
TRIM49	Physical association	Medium	0.56	3
TRIP6	Physical association	Medium	0.56	90
TTC1	Physical association	Medium	0.56	7
TTC19	Physical association	Medium	0.56	33
TUBA1A	Physical association	Medium	0.56	7
TUBB	Physical association	Medium	0.56	17
TUBB6	Physical association	Medium	0.56	4
TWIST1	Physical association	Medium	0.56	22
TWIST2	Physical association	Medium	0.56	10
TXN2	Physical association	Medium	0.56	60
U2AF1	Physical association	Medium	0.56	26
UBA1	Physical association	Medium	0.56	9
UBC	Physical association	Medium	0.56	56
UBE2D4	Physical association	Medium	0.56	39
UBE2H	Physical association	Medium	0.56	9
UBE2I	Physical association	Medium	0.56	40
UBQLN2	Physical association	Medium	0.56	212
USH1G	Physical association	Medium	0.56	19
USP18	Physical association	Medium	0.56	2
USP24	Physical association	Medium	0.56	1
UTP6	Physical association	Medium	0.56	3
VAC14	Physical association	Medium	0.56	83
VAT1L	Physical association	Medium	0.56	2
VPS37A	Physical association	Medium	0.56	18
VPS4B	Physical association	Medium	0.56	6
WWP2	Physical association	Medium	0.56	51
XAB2	Physical association	Medium	0.56	12
YIF1A	Physical association	Medium	0.56	66
ZBP1	Physical association	Medium	0.56	1
ZCCHC12	Physical association	Medium	0.56	18
ZFP2	Physical association	Medium	0.56	10
ZHX1	Physical association	Medium	0.56	4
ZHX1-C8orf76	Physical association	Medium	0.56	13
ZKSCAN3	Physical association	Medium	0.56	12
ZKSCAN8	Physical association	Medium	0.56	14
ZNF138	Physical association	Medium	0.56	16
ZNF19	Physical association	Medium	0.56	23
ZNF2	Physical association	Medium	0.56	4
ZNF281	Physical association	Medium	0.56	4
ZNF286A	Physical association	Medium	0.56	13
ZNF366	Physical association	Medium	0.56	22
ZNF436	Physical association	Medium	0.56	19
ZNF497	Physical association	Medium	0.56	41
ZNF500	Physical association	Medium	0.56	8
ZNF57	Physical association	Medium	0.56	14
ZNF572	Physical association	Medium	0.56	58
ZNF697	Physical association	Medium	0.56	4
ZNG1C	Physical association	Medium	0.56	6
ZSCAN9	Physical association	Medium	0.56	21
ZXDC	Physical association	Medium	0.56	19
OSTF1	Physical association	Medium	0.55	8
PIK3R1	Physical association	Medium	0.55	41
TACC1	Physical association	Medium	0.55	10
TCERG1	Physical association	Medium	0.55	2
TRAFD1	Physical association	Medium	0.55	4
PRMT2	Physical association	Medium	0.55	6
SNCA	Physical association	Medium	0.54	124
HMGB1	Physical association	Medium	0.52	20
CEP126	Physical association	Medium	0.51	11
CHD3	Physical association	Medium	0.51	14
ECH1	Physical association	Medium	0.51	5
ELP1	Physical association	Medium	0.51	6
HEY2	Physical association	Medium	0.51	17
HMG20A	Physical association	Medium	0.51	52
MAGEB6	Physical association	Medium	0.51	12
MBD1	Physical association	Medium	0.51	12
SP1	Physical association	Medium	0.51	24
TAF4	Physical association	Medium	0.51	3
XAGE3	Physical association	Medium	0.51	4
NBR1	Physical association	Medium	0.46	13
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
HTT is not a metabolic protein