Protein interactions for OPTN - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	OPTN
Gene descriptionⁱ Full gene name according to HGNC.	Optineurin
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Skeletal muscle - Striated muscle contraction (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Group enriched (skeletal muscle, tongue)
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.40
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Cytosol
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

Highlight:

Off

Subcell location

Predicted location

Tissue specificity

Protein class

Filter menu »

e.g. Brain enriched, Localized to mitochondria, Skeletal muscle - Striated muscle contraction

Field

Cluster

Pathway

Number of interactions:

127

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
TNIP1	Physical association	High	0.96	67
WASHC3	Physical association	High	0.95	44
TBK1	Physical association	High	0.9	30
HTT	Direct interaction	High	0.82	665
TBC1D15	Physical association	High	0.81	8
CDC23	Physical association	High	0.79	69
TBC1D17	Physical association	High	0.74	1
DAZAP2	Physical association	High	0.72	124
RBM12	Physical association	High	0.72	2
ZNF670	Physical association	High	0.72	19
HACE1	Direct interaction	High	0.69	3
ZMAT2	Physical association	High	0.68	44
LNX2	Physical association	High	0.67	63
ZNF426	Physical association	High	0.67	33
RAB8A	Physical association	High	0.63	18
SQSTM1	Physical association	Medium	0.56	36
ABHD17C	Physical association	Medium	0.56	11
ACSS3	Physical association	Medium	0.56	1
ANXA5	Physical association	Medium	0.56	5
AP3B1	Physical association	Medium	0.56	5
ARRDC3	Physical association	Medium	0.56	36
ASCL4	Physical association	Medium	0.56	34
ASMTL	Physical association	Medium	0.56	8
ATL1	Physical association	Medium	0.56	17
BEGAIN	Physical association	Medium	0.56	29
BIRC5	Physical association	Medium	0.56	22
BTN3A2	Physical association	Medium	0.56	3
C17orf67	Physical association	Medium	0.56	2
C8orf48	Physical association	Medium	0.56	17
CAPN1	Physical association	Medium	0.56	7
CCDC13	Physical association	Medium	0.56	37
CENPA	Physical association	Medium	0.56	18
CEP250	Physical association	Medium	0.56	2
CEP72	Physical association	Medium	0.56	19
CFL1	Physical association	Medium	0.56	12
CNIH3	Physical association	Medium	0.56	23
CPN1	Physical association	Medium	0.56	4
CRYM	Physical association	Medium	0.56	2
DKK4	Physical association	Medium	0.56	4
DUS3L	Physical association	Medium	0.56	1
ENTPD2	Physical association	Medium	0.56	2
FXR2	Physical association	Medium	0.56	58
GABRG1	Physical association	Medium	0.56	1
GPANK1	Physical association	Medium	0.56	65
H3C13	Physical association	Medium	0.56	27
H3C14	Physical association	Medium	0.56	27
H3C15	Physical association	Medium	0.56	27
HDAC10	Physical association	Medium	0.56	6
HLA-DPB1	Physical association	Medium	0.56	1
HSF2BP	Physical association	Medium	0.56	223
HTR1E	Physical association	Medium	0.56	2
IK	Physical association	Medium	0.56	21
IL4I1	Physical association	Medium	0.56	2
IRF8	Physical association	Medium	0.56	2
IRGM	Physical association	Medium	0.56	1
KIAA0825	Physical association	Medium	0.56	3
KRTAP9-2	Physical association	Medium	0.56	123
LDHAL6B	Physical association	Medium	0.56	17
LITAF	Physical association	Medium	0.56	47
LPXN	Physical association	Medium	0.56	10
MECP2	Physical association	Medium	0.56	33
MGARP	Physical association	Medium	0.56	14
MGAT4B	Physical association	Medium	0.56	2
MKNK1	Physical association	Medium	0.56	6
MMAB	Physical association	Medium	0.56	4
MTFP1	Physical association	Medium	0.56	1
MYEOV	Physical association	Medium	0.56	3
NIP7	Physical association	Medium	0.56	3
NMRAL1	Physical association	Medium	0.56	2
NUDCD2	Physical association	Medium	0.56	6
ODF3L2	Physical association	Medium	0.56	10
P2RY4	Physical association	Medium	0.56	1
PALM2AKAP2	Physical association	Medium	0.56	1
PAPSS2	Physical association	Medium	0.56	3
PAXX	Physical association	Medium	0.56	2
PDZK1IP1	Physical association	Medium	0.56	71
PEX16	Physical association	Medium	0.56	23
PICK1	Physical association	Medium	0.56	275
POU6F2	Physical association	Medium	0.56	102
PPP1R11	Physical association	Medium	0.56	9
PROS1	Physical association	Medium	0.56	4
PSMC2	Physical association	Medium	0.56	13
QKI	Physical association	Medium	0.56	15
RAB10	Physical association	Medium	0.56	6
RASSF2	Physical association	Medium	0.56	15
RETREG3	Physical association	Medium	0.56	91
RNF112	Physical association	Medium	0.56	18
RNF216	Physical association	Medium	0.56	12
RNF5	Physical association	Medium	0.56	44
RPP25	Physical association	Medium	0.56	25
S100A1	Physical association	Medium	0.56	15
SDCBP	Physical association	Medium	0.56	240
SLC2A13	Physical association	Medium	0.56	3
SLC39A1	Physical association	Medium	0.56	7
SMAD1	Physical association	Medium	0.56	13
SMARCD1	Physical association	Medium	0.56	104
SNW1	Physical association	Medium	0.56	89
SPATS1	Physical association	Medium	0.56	17
SPHK2	Physical association	Medium	0.56	1
ST8SIA1	Physical association	Medium	0.56	1
STIM1	Physical association	Medium	0.56	20
SUCLA2	Physical association	Medium	0.56	7
TARS1	Physical association	Medium	0.56	4
THADA	Physical association	Medium	0.56	3
THAP6	Physical association	Medium	0.56	13
THOP1	Physical association	Medium	0.56	1
UBE2A	Physical association	Medium	0.56	17
USP2	Physical association	Medium	0.56	78
ZBTB14	Physical association	Medium	0.56	54
ZBTB48	Physical association	Medium	0.56	23
ZHX1-C8orf76	Physical association	Medium	0.56	13
ZKSCAN1	Physical association	Medium	0.56	3
ZNF17	Physical association	Medium	0.56	11
ZNF281	Physical association	Medium	0.56	4
ZNF329	Physical association	Medium	0.56	21
ZNF398	Physical association	Medium	0.56	16
ZNF419	Physical association	Medium	0.56	3
ZNF597	Physical association	Medium	0.56	8
ZYG11B	Physical association	Medium	0.56	3
DYSF	Physical association	Medium	0.5	16
MPP1	Physical association	Medium	0.5	22
AKAP6	Physical association	Medium	0.45	1
DST	Physical association	Medium	0.45	6
SLMAP	Physical association	Medium	0.45	4
SNX6	Physical association	Medium	0.45	7
TTN	Physical association	Medium	0.45	13
VWF	Physical association	Medium	0.45	4
Show allShow less

METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
OPTN is not a metabolic protein