Protein interactions for RETREG3 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RETREG3
Gene descriptionⁱ Full gene name according to HGNC.	Reticulophagy regulator family member 3
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Testis - Spermatogenesis (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.18
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Nucleoplasm, Nuclear membrane In addition localized to the Cytosol
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

Highlight:

Off

Subcell location

Predicted location

Tissue specificity

Protein class

Filter menu »

e.g. Brain enriched, Localized to mitochondria, Testis - Spermatogenesis

Field

Cluster

Pathway

Number of interactions:

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
GABARAPL1	Physical association	High	0.83	59
ABHD16A	Physical association	High	0.78	46
ARL6IP1	Physical association	High	0.78	60
MAP1LC3A	Physical association	High	0.78	14
STAP1	Physical association	High	0.72	3
ACSL5	Physical association	Medium	0.56	9
AGPAT4	Physical association	Medium	0.56	22
ARPC3	Physical association	Medium	0.56	15
ATP6V0C	Physical association	Medium	0.56	47
BET1	Physical association	Medium	0.56	41
BNIP1	Physical association	Medium	0.56	14
C16orf92	Physical association	Medium	0.56	10
CCDC167	Physical association	Medium	0.56	32
CCL4L2	Physical association	Medium	0.56	31
CDIPT	Physical association	Medium	0.56	47
CDS1	Physical association	Medium	0.56	5
CMTM3	Physical association	Medium	0.56	19
CMTM7	Physical association	Medium	0.56	39
CSGALNACT2	Physical association	Medium	0.56	16
CYB5B	Physical association	Medium	0.56	37
CYP4F2	Physical association	Medium	0.56	33
DERL1	Physical association	Medium	0.56	25
DHRSX	Physical association	Medium	0.56	14
ERG28	Physical association	Medium	0.56	48
FAXDC2	Physical association	Medium	0.56	28
FKBP8	Physical association	Medium	0.56	32
FUNDC2	Physical association	Medium	0.56	22
GABARAPL2	Physical association	Medium	0.56	74
GIMAP5	Physical association	Medium	0.56	53
GOSR2	Physical association	Medium	0.56	45
HMOX2	Physical association	Medium	0.56	44
IFITM3	Physical association	Medium	0.56	22
JAGN1	Physical association	Medium	0.56	102
LEMD1	Physical association	Medium	0.56	12
LPAR3	Physical association	Medium	0.56	46
LPCAT2	Physical association	Medium	0.56	7
LRCH4	Physical association	Medium	0.56	14
MAL2	Physical association	Medium	0.56	37
MALL	Physical association	Medium	0.56	51
MCRS1	Physical association	Medium	0.56	97
MOB2	Physical association	Medium	0.56	9
MOSPD3	Physical association	Medium	0.56	13
NRM	Physical association	Medium	0.56	50
OPTN	Physical association	Medium	0.56	127
ORMDL2	Physical association	Medium	0.56	18
ORMDL3	Physical association	Medium	0.56	23
OTULINL	Physical association	Medium	0.56	11
PLP2	Physical association	Medium	0.56	58
PLPP6	Physical association	Medium	0.56	44
PNLIPRP1	Physical association	Medium	0.56	31
PRAF2	Physical association	Medium	0.56	26
RABAC1	Physical association	Medium	0.56	48
RUSF1	Physical association	Medium	0.56	49
SCD	Physical association	Medium	0.56	36
SEC22A	Physical association	Medium	0.56	88
SENP2	Physical association	Medium	0.56	18
SERP2	Physical association	Medium	0.56	42
SFT2D1	Physical association	Medium	0.56	27
SFXN3	Physical association	Medium	0.56	16
SLC30A3	Physical association	Medium	0.56	22
SMCO4	Physical association	Medium	0.56	51
SMIM1	Physical association	Medium	0.56	48
STX5	Physical association	Medium	0.56	26
STX7	Physical association	Medium	0.56	36
STX8	Physical association	Medium	0.56	58
TBRG4	Physical association	Medium	0.56	17
TCEA2	Physical association	Medium	0.56	88
TECR	Physical association	Medium	0.56	22
TMEM100	Physical association	Medium	0.56	32
TMEM11	Physical association	Medium	0.56	40
TMEM120B	Physical association	Medium	0.56	46
TMEM176A	Physical association	Medium	0.56	12
TMEM203	Physical association	Medium	0.56	34
TMEM218	Physical association	Medium	0.56	61
TMEM222	Physical association	Medium	0.56	30
TMEM243	Physical association	Medium	0.56	37
TMEM254	Physical association	Medium	0.56	35
TMEM42	Physical association	Medium	0.56	41
TMEM60	Physical association	Medium	0.56	86
TMEM65	Physical association	Medium	0.56	29
TMPPE	Physical association	Medium	0.56	30
TPRG1	Physical association	Medium	0.56	15
TSPO2	Physical association	Medium	0.56	49
UBIAD1	Physical association	Medium	0.56	33
VAMP3	Physical association	Medium	0.56	46
VAMP4	Physical association	Medium	0.56	35
VAMP5	Physical association	Medium	0.56	58
VAPA	Physical association	Medium	0.56	37
VAPB	Physical association	Medium	0.56	33
YIPF1	Physical association	Medium	0.56	30
YIPF6	Physical association	Medium	0.56	72
Show allShow less

METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
RETREG3 is not a metabolic protein