Protein interactions for PICK1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PICK1
Gene descriptionⁱ Full gene name according to HGNC.	Protein interacting with PRKCA 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Spermatids - Flagellum assembly (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.21
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Cytosol
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Spermatids - Flagellum assembly

Field

Cluster

Pathway

Number of interactions:

275

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
ABT1	Physical association	Medium	0.56	13
AKT2	Physical association	Medium	0.56	4
AP1M1	Physical association	Medium	0.56	67
ARHGEF3	Physical association	Medium	0.56	7
ARHGEF5	Physical association	Medium	0.56	18
ARL6IP1	Physical association	Medium	0.56	60
ARMCX1	Physical association	Medium	0.56	6
ATOSB	Physical association	Medium	0.56	50
ATP5IF1	Physical association	Medium	0.56	14
AVPI1	Physical association	Medium	0.56	29
BAHD1	Physical association	Medium	0.56	54
BCL2L14	Physical association	Medium	0.56	5
BEX1	Physical association	Medium	0.56	12
BLK	Physical association	Medium	0.56	22
BLOC1S2	Physical association	Medium	0.56	24
BOLA3	Physical association	Medium	0.56	7
BRD1	Physical association	Medium	0.56	8
BUD31	Physical association	Medium	0.56	3
BYSL	Physical association	Medium	0.56	119
C1orf35	Physical association	Medium	0.56	32
C4orf46	Physical association	Medium	0.56	7
C8orf33	Physical association	Medium	0.56	20
CBX8	Physical association	Medium	0.56	78
CCDC102B	Physical association	Medium	0.56	87
CCDC103	Physical association	Medium	0.56	17
CCNH	Physical association	Medium	0.56	37
CDC42EP2	Physical association	Medium	0.56	5
CDC73	Physical association	Medium	0.56	30
CDCA7L	Physical association	Medium	0.56	52
CDK2AP1	Physical association	Medium	0.56	6
CDKL3	Physical association	Medium	0.56	22
CDKN2B	Physical association	Medium	0.56	15
CDKN2D	Physical association	Medium	0.56	41
CEP19	Physical association	Medium	0.56	41
CEP290	Physical association	Medium	0.56	9
CEP57L1	Physical association	Medium	0.56	27
CEP95	Physical association	Medium	0.56	13
CGGBP1	Physical association	Medium	0.56	13
CHMP1B	Physical association	Medium	0.56	7
CPNE2	Physical association	Medium	0.56	13
CRY2	Physical association	Medium	0.56	29
CSNK2A2	Physical association	Medium	0.56	7
CTSG	Physical association	Medium	0.56	4
CUTC	Physical association	Medium	0.56	12
CWF19L2	Physical association	Medium	0.56	65
DCTD	Physical association	Medium	0.56	8
DCUN1D5	Physical association	Medium	0.56	6
DDX55	Physical association	Medium	0.56	3
DDX6	Physical association	Medium	0.56	66
DMC1	Physical association	Medium	0.56	10
DMD	Physical association	Medium	0.56	9
DNAJB13	Physical association	Medium	0.56	9
DNTTIP1	Physical association	Medium	0.56	11
DNTTIP2	Physical association	Medium	0.56	4
DPF2	Physical association	Medium	0.56	10
DRAP1	Physical association	Medium	0.56	15
DUSP29	Physical association	Medium	0.56	15
EAF1	Physical association	Medium	0.56	41
EEF2KMT	Physical association	Medium	0.56	12
EFHC2	Physical association	Medium	0.56	79
EHHADH	Physical association	Medium	0.56	94
EIF1AD	Physical association	Medium	0.56	30
EIF3D	Physical association	Medium	0.56	27
EIF4A3	Physical association	Medium	0.56	30
EIF4EBP1	Physical association	Medium	0.56	11
EIF5A	Physical association	Medium	0.56	9
ENKD1	Physical association	Medium	0.56	159
EPM2AIP1	Physical association	Medium	0.56	40
ESCO2	Physical association	Medium	0.56	3
EXOSC5	Physical association	Medium	0.56	42
FAM161A	Physical association	Medium	0.56	118
FAM161B	Physical association	Medium	0.56	54
FAM219B	Physical association	Medium	0.56	2
FAM90A1	Physical association	Medium	0.56	128
FAM9A	Physical association	Medium	0.56	47
FBXL3	Physical association	Medium	0.56	2
FBXL8	Physical association	Medium	0.56	3
FGF16	Physical association	Medium	0.56	6
FKBP6	Physical association	Medium	0.56	26
FLYWCH1	Physical association	Medium	0.56	8
GADD45GIP1	Physical association	Medium	0.56	55
GAS2L2	Physical association	Medium	0.56	29
GLYCTK	Physical association	Medium	0.56	48
GPC4	Physical association	Medium	0.56	1
GPKOW	Physical association	Medium	0.56	40
GRXCR1	Physical association	Medium	0.56	7
GTF2E2	Physical association	Medium	0.56	5
GTPBP2	Physical association	Medium	0.56	12
HEXIM2	Physical association	Medium	0.56	38
HMBOX1	Physical association	Medium	0.56	76
HMBS	Physical association	Medium	0.56	2
HMG20A	Physical association	Medium	0.56	52
HOPX	Physical association	Medium	0.56	2
HOXA5	Physical association	Medium	0.56	4
HSD17B14	Physical association	Medium	0.56	20
HSF2	Physical association	Medium	0.56	8
HSF2BP	Physical association	Medium	0.56	223
HTT	Physical association	Medium	0.56	665
ID2	Physical association	Medium	0.56	20
IHO1	Physical association	Medium	0.56	62
ILF2	Physical association	Medium	0.56	7
INO80B	Physical association	Medium	0.56	49
INO80E	Physical association	Medium	0.56	19
INPP5J	Physical association	Medium	0.56	15
IP6K1	Physical association	Medium	0.56	4
ISCU	Physical association	Medium	0.56	16
KAT5	Physical association	Medium	0.56	180
KCTD1	Physical association	Medium	0.56	16
KCTD6	Physical association	Medium	0.56	20
KCTD9	Physical association	Medium	0.56	77
KIAA1328	Physical association	Medium	0.56	28
L3MBTL2	Physical association	Medium	0.56	36
LCLAT1	Physical association	Medium	0.56	3
LCN2	Physical association	Medium	0.56	47
LGALS14	Physical association	Medium	0.56	43
LMO1	Physical association	Medium	0.56	88
LONRF1	Physical association	Medium	0.56	77
LRRC73	Physical association	Medium	0.56	7
LZTFL1	Physical association	Medium	0.56	15
LZTS1	Physical association	Medium	0.56	73
MAGEA4	Physical association	Medium	0.56	16
MAGEB4	Physical association	Medium	0.56	29
MAP2K6	Physical association	Medium	0.56	7
MAPK9	Physical association	Medium	0.56	48
MAPRE3	Physical association	Medium	0.56	41
MGME1	Physical association	Medium	0.56	2
MNS1	Physical association	Medium	0.56	23
MOB3C	Physical association	Medium	0.56	14
MORF4L2	Physical association	Medium	0.56	42
MORN3	Physical association	Medium	0.56	57
MOS	Physical association	Medium	0.56	46
MRI1	Physical association	Medium	0.56	7
MRNIP	Physical association	Medium	0.56	9
MSS51	Physical association	Medium	0.56	19
MTA1	Physical association	Medium	0.56	23
MTG1	Physical association	Medium	0.56	3
NATD1	Physical association	Medium	0.56	7
NDEL1	Physical association	Medium	0.56	60
NME7	Physical association	Medium	0.56	62
NMNAT1	Physical association	Medium	0.56	11
NOC4L	Physical association	Medium	0.56	11
OARD1	Physical association	Medium	0.56	3
OPTN	Physical association	Medium	0.56	127
OSGIN1	Physical association	Medium	0.56	30
PAFAH1B3	Physical association	Medium	0.56	7
PAX6	Physical association	Medium	0.56	79
PBX4	Physical association	Medium	0.56	60
PCBD1	Physical association	Medium	0.56	12
PDCD5	Physical association	Medium	0.56	2
PEBP1	Physical association	Medium	0.56	5
PHF19	Physical association	Medium	0.56	24
PKN1	Physical association	Medium	0.56	59
PKNOX2	Physical association	Medium	0.56	29
PNKP	Physical association	Medium	0.56	34
PNO1	Physical association	Medium	0.56	3
POLR3C	Physical association	Medium	0.56	29
PPL	Physical association	Medium	0.56	31
PRPF18	Physical association	Medium	0.56	63
PRPF31	Physical association	Medium	0.56	118
PSMA1	Physical association	Medium	0.56	135
PSME3	Physical association	Medium	0.56	35
PTRH1	Physical association	Medium	0.56	4
QARS1	Physical association	Medium	0.56	53
RAD51D	Physical association	Medium	0.56	35
RASAL3	Physical association	Medium	0.56	15
RFC3	Physical association	Medium	0.56	7
RIMS3	Physical association	Medium	0.56	5
RIN1	Physical association	Medium	0.56	38
RNF8	Physical association	Medium	0.56	41
RNPS1	Physical association	Medium	0.56	46
ROPN1	Physical association	Medium	0.56	37
RPIA	Physical association	Medium	0.56	15
RPP25	Physical association	Medium	0.56	25
RRP8	Physical association	Medium	0.56	4
RXRB	Physical association	Medium	0.56	10
RXRG	Physical association	Medium	0.56	13
SCAND1	Physical association	Medium	0.56	40
SCNM1	Physical association	Medium	0.56	148
SEPTIN1	Physical association	Medium	0.56	17
SERBP1	Physical association	Medium	0.56	6
SERTAD1	Physical association	Medium	0.56	20
SERTAD3	Physical association	Medium	0.56	37
SH2D4A	Physical association	Medium	0.56	63
SH3GLB2	Physical association	Medium	0.56	19
SLIRP	Physical association	Medium	0.56	11
SLX9	Physical association	Medium	0.56	3
SMARCD1	Physical association	Medium	0.56	104
SNRNP25	Physical association	Medium	0.56	15
SNRPA1	Physical association	Medium	0.56	7
SNRPB2	Physical association	Medium	0.56	16
SNW1	Physical association	Medium	0.56	89
SPANXN2	Physical association	Medium	0.56	37
SSNA1	Physical association	Medium	0.56	12
SYT17	Physical association	Medium	0.56	34
TBC1D22B	Physical association	Medium	0.56	46
TBC1D7	Physical association	Medium	0.56	22
TCEA2	Physical association	Medium	0.56	88
TCEANC2	Physical association	Medium	0.56	3
TDO2	Physical association	Medium	0.56	19
TFIP11	Physical association	Medium	0.56	179
THAP6	Physical association	Medium	0.56	13
THAP7	Physical association	Medium	0.56	47
TLNRD1	Physical association	Medium	0.56	2
TPM4	Physical association	Medium	0.56	3
TRAF4	Physical association	Medium	0.56	73
TRAF5	Physical association	Medium	0.56	35
TRIM44	Physical association	Medium	0.56	3
TRIM54	Physical association	Medium	0.56	151
TRIML2	Physical association	Medium	0.56	39
TRMT2A	Physical association	Medium	0.56	5
TSGA10IP	Physical association	Medium	0.56	83
TSN	Physical association	Medium	0.56	10
TSTD2	Physical association	Medium	0.56	16
TTC23L	Physical association	Medium	0.56	19
TXNDC9	Physical association	Medium	0.56	18
TXNL4B	Physical association	Medium	0.56	11
TYW3	Physical association	Medium	0.56	2
UBE2E3	Physical association	Medium	0.56	24
UBE2K	Physical association	Medium	0.56	60
USHBP1	Physical association	Medium	0.56	162
USP2	Physical association	Medium	0.56	78
UTP3	Physical association	Medium	0.56	4
VEZF1	Physical association	Medium	0.56	40
VPS25	Physical association	Medium	0.56	15
XPA	Physical association	Medium	0.56	17
YES1	Physical association	Medium	0.56	44
YPEL2	Physical association	Medium	0.56	2
YTHDC1	Physical association	Medium	0.56	16
ZBED1	Physical association	Medium	0.56	33
ZBTB2	Physical association	Medium	0.56	21
ZBTB24	Physical association	Medium	0.56	52
ZBTB49	Physical association	Medium	0.56	11
ZFP2	Physical association	Medium	0.56	10
ZMAT2	Physical association	Medium	0.56	44
ZMYND12	Physical association	Medium	0.56	66
ZNF165	Physical association	Medium	0.56	31
ZNF17	Physical association	Medium	0.56	11
ZNF205	Physical association	Medium	0.56	6
ZNF264	Physical association	Medium	0.56	14
ZNF276	Physical association	Medium	0.56	9
ZNF286A	Physical association	Medium	0.56	13
ZNF329	Physical association	Medium	0.56	21
ZNF330	Physical association	Medium	0.56	43
ZNF35	Physical association	Medium	0.56	24
ZNF408	Physical association	Medium	0.56	51
ZNF414	Physical association	Medium	0.56	42
ZNF417	Physical association	Medium	0.56	140
ZNF438	Physical association	Medium	0.56	50
ZNF497	Physical association	Medium	0.56	41
ZNF524	Physical association	Medium	0.56	22
ZNF575	Physical association	Medium	0.56	22
ZNF576	Physical association	Medium	0.56	9
ZNF593	Physical association	Medium	0.56	3
ZNF624	Physical association	Medium	0.56	4
ZNF691	Physical association	Medium	0.56	2
ZNF71	Physical association	Medium	0.56	18
ZNF764	Physical association	Medium	0.56	26
ZNF774	Physical association	Medium	0.56	68
ZSCAN21	Physical association	Medium	0.56	22
ZSCAN23	Physical association	Medium	0.56	17
ZZZ3	Physical association	Medium	0.56	8
FMR1	Physical association	Medium	0.55	13
UACA	Physical association	Medium	0.55	9
ASIC1	Physical association	Medium	0.54	2
SLC6A3	Physical association	Medium	0.54	6
ARX	Physical association	Medium	0.51	3
ASIC2	Physical association	Medium	0.51	1
CACNA1C	Physical association	Medium	0.51	3
DNMT1	Physical association	Medium	0.51	13
PTEN	Physical association	Medium	0.51	16
SLC6A2	Physical association	Medium	0.51	1
SMARCA2	Physical association	Medium	0.51	8
TSC1	Physical association	Medium	0.51	12
TSC2	Physical association	Medium	0.51	9
PRLHR	Physical association	Medium	0.46	1
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
PICK1 is not a metabolic protein