Protein interactions for USHBP1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	USHBP1
Gene descriptionⁱ Full gene name according to HGNC.	USH1 protein network component harmonin binding protein 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Adipose tissue - Mixed function (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.52
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Not available
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Adipose tissue - Mixed function

Field

Cluster

Pathway

Number of interactions:

162

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
SERTAD3	Physical association	High	0.79	37
C1orf216	Physical association	High	0.78	69
COPS4	Physical association	High	0.78	15
DYDC1	Physical association	High	0.78	24
BEX3	Physical association	High	0.72	25
BFSP2	Physical association	High	0.72	44
CCDC116	Physical association	High	0.72	24
CCDC24	Physical association	High	0.72	28
CENPP	Physical association	High	0.72	20
FAM110A	Physical association	High	0.72	41
IMP3	Physical association	High	0.72	12
KLHL38	Physical association	High	0.72	72
KRT38	Physical association	High	0.72	57
MAGEB4	Physical association	High	0.72	29
MCRS1	Physical association	High	0.72	97
MED4	Physical association	High	0.72	34
MOS	Physical association	High	0.72	46
PARVG	Physical association	High	0.72	23
SEC14L4	Physical association	High	0.72	19
SYNJ2BP	Physical association	High	0.72	22
TRIM54	Physical association	High	0.72	151
TXLNA	Physical association	High	0.72	76
TXLNB	Physical association	High	0.72	61
VPS28	Physical association	High	0.72	12
EXOC8	Physical association	High	0.7	67
HGS	Physical association	High	0.67	177
NDC80	Physical association	High	0.67	42
SMARCD1	Physical association	High	0.67	104
ARFIP2	Physical association	Medium	0.56	42
ARMC5	Physical association	Medium	0.56	8
ASB15	Physical association	Medium	0.56	10
ATP5PO	Physical association	Medium	0.56	18
BCAS2	Physical association	Medium	0.56	49
BCL2L11	Physical association	Medium	0.56	15
BEX2	Physical association	Medium	0.56	67
BICRAL	Physical association	Medium	0.56	13
BLOC1S1	Physical association	Medium	0.56	11
BLZF1	Physical association	Medium	0.56	84
BORCS6	Physical association	Medium	0.56	30
BRAT1	Physical association	Medium	0.56	7
C1orf109	Physical association	Medium	0.56	121
CCDC103	Physical association	Medium	0.56	17
CCDC121	Physical association	Medium	0.56	4
CCDC146	Physical association	Medium	0.56	42
CCDC148	Physical association	Medium	0.56	2
CCDC22	Physical association	Medium	0.56	19
CCDC87	Physical association	Medium	0.56	7
CDC37	Physical association	Medium	0.56	124
CDC5L	Physical association	Medium	0.56	48
CDKN1A	Physical association	Medium	0.56	49
CEP68	Physical association	Medium	0.56	5
CFAP206	Physical association	Medium	0.56	46
CNNM3	Physical association	Medium	0.56	59
COPS6	Physical association	Medium	0.56	56
COPS8	Physical association	Medium	0.56	16
CTNNBIP1	Physical association	Medium	0.56	14
CTTNBP2NL	Physical association	Medium	0.56	10
CYTH4	Physical association	Medium	0.56	14
DCTN2	Physical association	Medium	0.56	35
DEUP1	Physical association	Medium	0.56	34
DTNB	Physical association	Medium	0.56	20
EIF4E2	Physical association	Medium	0.56	32
ENKD1	Physical association	Medium	0.56	159
ERCC1	Physical association	Medium	0.56	9
FAM124B	Physical association	Medium	0.56	24
FAM161B	Physical association	Medium	0.56	54
FCRL5	Physical association	Medium	0.56	2
FTL	Physical association	Medium	0.56	13
GAS8	Physical association	Medium	0.56	97
GATAD2B	Physical association	Medium	0.56	19
GEM	Physical association	Medium	0.56	88
GMCL2	Physical association	Medium	0.56	22
GOLGA6L9	Physical association	Medium	0.56	177
GOLGA8F	Physical association	Medium	0.56	19
GPSM3	Physical association	Medium	0.56	38
HAUS1	Physical association	Medium	0.56	83
HAUS8	Physical association	Medium	0.56	18
HMG20A	Physical association	Medium	0.56	52
HMG20B	Physical association	Medium	0.56	16
IFT20	Physical association	Medium	0.56	24
INTS4	Physical association	Medium	0.56	5
ITGB3BP	Physical association	Medium	0.56	28
KANK2	Physical association	Medium	0.56	151
KIAA0753	Physical association	Medium	0.56	17
KLC4	Physical association	Medium	0.56	18
KPNA2	Physical association	Medium	0.56	32
KRT14	Physical association	Medium	0.56	21
KRT16	Physical association	Medium	0.56	46
KRT20	Physical association	Medium	0.56	32
KRT26	Physical association	Medium	0.56	18
KRT27	Physical association	Medium	0.56	113
KRT28	Physical association	Medium	0.56	15
KRT31	Physical association	Medium	0.56	284
KRT37	Physical association	Medium	0.56	36
KRT40	Physical association	Medium	0.56	288
KRT71	Physical association	Medium	0.56	18
KRT75	Physical association	Medium	0.56	103
KRT79	Physical association	Medium	0.56	18
LENG1	Physical association	Medium	0.56	63
MCCD1	Physical association	Medium	0.56	20
MCM7	Physical association	Medium	0.56	25
MED11	Physical association	Medium	0.56	11
MEI4	Physical association	Medium	0.56	32
MIIP	Physical association	Medium	0.56	24
MKRN3	Physical association	Medium	0.56	118
MNS1	Physical association	Medium	0.56	23
MRPS23	Physical association	Medium	0.56	3
MYOG	Physical association	Medium	0.56	27
MYOZ1	Physical association	Medium	0.56	28
NUP62	Physical association	Medium	0.56	61
ODAD3	Physical association	Medium	0.56	16
OIP5	Physical association	Medium	0.56	113
PAX6	Physical association	Medium	0.56	79
PBX4	Physical association	Medium	0.56	60
PICK1	Physical association	Medium	0.56	275
PKN1	Physical association	Medium	0.56	59
PKNOX2	Physical association	Medium	0.56	29
PMF1	Physical association	Medium	0.56	13
POP5	Physical association	Medium	0.56	14
PPP1R12C	Physical association	Medium	0.56	14
PPP1R7	Physical association	Medium	0.56	29
PPP2R5A	Physical association	Medium	0.56	17
PPP2R5D	Physical association	Medium	0.56	10
PRKAA2	Physical association	Medium	0.56	78
QARS1	Physical association	Medium	0.56	53
RASAL2	Physical association	Medium	0.56	4
RIBC1	Physical association	Medium	0.56	21
RINT1	Physical association	Medium	0.56	68
RNF20	Physical association	Medium	0.56	13
RTP5	Physical association	Medium	0.56	49
SAPCD2	Physical association	Medium	0.56	11
SAT1	Physical association	Medium	0.56	40
SCNM1	Physical association	Medium	0.56	148
SCT	Physical association	Medium	0.56	2
SEMA4C	Physical association	Medium	0.56	14
SHC3	Physical association	Medium	0.56	31
SMARCE1	Physical association	Medium	0.56	56
SOHLH1	Physical association	Medium	0.56	23
SPG21	Physical association	Medium	0.56	129
SRI	Physical association	Medium	0.56	6
STX11	Physical association	Medium	0.56	80
TASOR2	Physical association	Medium	0.56	34
TCHP	Physical association	Medium	0.56	40
TEKT1	Physical association	Medium	0.56	21
THADA	Physical association	Medium	0.56	3
THOC1	Physical association	Medium	0.56	15
TIMM13	Physical association	Medium	0.56	2
TRIML2	Physical association	Medium	0.56	39
TSG101	Physical association	Medium	0.56	50
TTC9C	Physical association	Medium	0.56	14
UBE2W	Physical association	Medium	0.56	13
UBXN11	Physical association	Medium	0.56	13
USP2	Physical association	Medium	0.56	78
ZBTB42	Physical association	Medium	0.56	38
ZNF417	Physical association	Medium	0.56	140
ZNF655	Physical association	Medium	0.56	117
ZNF765	Physical association	Medium	0.56	3
FANCG	Physical association	Medium	0.55	35
PRC1	Physical association	Medium	0.55	5
BET1	Physical association	Medium	0.51	41
NOC4L	Physical association	Medium	0.51	11
CHCHD3	Physical association	Medium	0.49	37
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
USHBP1 is not a metabolic protein