Protein interactions for BLZF1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	BLZF1
Gene descriptionⁱ Full gene name according to HGNC.	Basic leucine zipper nuclear factor 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Testis - Unknown function (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.23
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Golgi apparatus In addition localized to the Nucleoplasm
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Testis - Unknown function

Field

Cluster

Pathway

Number of interactions:

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
PRKAB2	Physical association	High	0.84	126
SMAD3	Physical association	High	0.81	52
CINP	Physical association	High	0.78	32
LMO1	Physical association	High	0.78	88
RAB2A	Physical association	High	0.78	15
ZBTB24	Physical association	High	0.78	52
BEX2	Physical association	High	0.72	67
CHCHD3	Physical association	High	0.72	37
FHL2	Physical association	High	0.72	96
GEM	Physical association	High	0.72	88
IQUB	Physical association	High	0.72	56
KLHL38	Physical association	High	0.72	72
RAB2B	Physical association	High	0.72	11
RAB39A	Physical association	High	0.72	5
SCNM1	Physical association	High	0.72	148
TBC1D7	Physical association	High	0.72	22
BCL6	Physical association	High	0.68	40
OAZ3	Physical association	High	0.67	8
ZNF410	Physical association	High	0.67	10
HRAS	Physical association	High	0.66	87
AQP1	Physical association	Medium	0.56	106
BAG3	Physical association	Medium	0.56	58
BAG4	Physical association	Medium	0.56	60
CARD9	Physical association	Medium	0.56	52
CCDC120	Physical association	Medium	0.56	90
CCNH	Physical association	Medium	0.56	37
CDC37	Physical association	Medium	0.56	124
CDK18	Physical association	Medium	0.56	45
CFAP206	Physical association	Medium	0.56	46
ENKD1	Physical association	Medium	0.56	159
ERCC3	Physical association	Medium	0.56	14
EXOC8	Physical association	Medium	0.56	67
FAM90A1	Physical association	Medium	0.56	128
FGFR3	Physical association	Medium	0.56	192
FRMD6	Physical association	Medium	0.56	12
FRS3	Physical association	Medium	0.56	77
GRIN2C	Physical association	Medium	0.56	58
GSN	Physical association	Medium	0.56	126
HOXC8	Physical association	Medium	0.56	74
IKZF3	Physical association	Medium	0.56	130
INO80B	Physical association	Medium	0.56	49
KANK2	Physical association	Medium	0.56	151
KAT5	Physical association	Medium	0.56	180
KCTD9	Physical association	Medium	0.56	77
KIF9	Physical association	Medium	0.56	42
LGALS14	Physical association	Medium	0.56	43
LMO2	Physical association	Medium	0.56	61
LNX1	Physical association	Medium	0.56	333
MFAP1	Physical association	Medium	0.56	79
MISP	Physical association	Medium	0.56	44
MKRN3	Physical association	Medium	0.56	118
MORN3	Physical association	Medium	0.56	57
NDEL1	Physical association	Medium	0.56	60
NTAQ1	Physical association	Medium	0.56	302
PCDHB12	Physical association	Medium	0.56	7
PIK3R3	Physical association	Medium	0.56	70
PKN1	Physical association	Medium	0.56	59
POLR1C	Physical association	Medium	0.56	87
PRPF18	Physical association	Medium	0.56	63
PSMA1	Physical association	Medium	0.56	135
RFC5	Physical association	Medium	0.56	21
RHOJ	Physical association	Medium	0.56	16
SPRED1	Physical association	Medium	0.56	308
SSX2	Physical association	Medium	0.56	9
SSX2B	Physical association	Medium	0.56	9
SYT17	Physical association	Medium	0.56	34
TBC1D22B	Physical association	Medium	0.56	46
TCAP	Physical association	Medium	0.56	34
TCF19	Physical association	Medium	0.56	12
TEKT4	Physical association	Medium	0.56	80
TNS2	Physical association	Medium	0.56	70
TRAPPC2L	Physical association	Medium	0.56	6
TRIM59	Physical association	Medium	0.56	15
TSTD2	Physical association	Medium	0.56	16
UBQLN1	Physical association	Medium	0.56	213
USHBP1	Physical association	Medium	0.56	162
VPS28	Physical association	Medium	0.56	12
ZBTB16	Physical association	Medium	0.56	43
ZGPAT	Physical association	Medium	0.56	25
ZIC1	Physical association	Medium	0.56	55
ZIM2	Physical association	Medium	0.56	26
ZNF124	Physical association	Medium	0.56	45
ZNF417	Physical association	Medium	0.56	140
ZNF76	Physical association	Medium	0.56	62
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
BLZF1 is not a metabolic protein