Protein interactions for SPRED1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SPRED1
Gene descriptionⁱ Full gene name according to HGNC.	Sprouty related EVH1 domain containing 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Mixed function (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.38
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Nucleoplasm
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Non-specific - Mixed function

Field

Cluster

Pathway

Number of interactions:

308

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
PPP1CA	Direct interaction	High	0.74	87
HPCAL4	Physical association	High	0.72	11
NCALD	Physical association	High	0.72	19
PIH1D2	Physical association	High	0.72	64
CDKN1A	Physical association	High	0.67	49
TRIB3	Physical association	High	0.61	54
NF1	Physical association	Medium	0.57	3
ACRV1	Physical association	Medium	0.56	3
ADAT2	Physical association	Medium	0.56	4
AGO2	Physical association	Medium	0.56	28
AKR1C1	Physical association	Medium	0.56	2
ALOX5	Physical association	Medium	0.56	15
ANKRD23	Physical association	Medium	0.56	17
APRT	Physical association	Medium	0.56	2
AQP1	Physical association	Medium	0.56	106
ASB13	Physical association	Medium	0.56	10
ASCL4	Physical association	Medium	0.56	34
ATL1	Physical association	Medium	0.56	17
ATP5IF1	Physical association	Medium	0.56	14
AXIN1	Physical association	Medium	0.56	40
BAHD1	Physical association	Medium	0.56	54
BAK1	Physical association	Medium	0.56	18
BATF	Physical association	Medium	0.56	18
BEX2	Physical association	Medium	0.56	67
BEX3	Physical association	Medium	0.56	25
BEX5	Physical association	Medium	0.56	16
BLZF1	Physical association	Medium	0.56	84
BRK1	Physical association	Medium	0.56	46
C18orf54	Physical association	Medium	0.56	7
C1orf216	Physical association	Medium	0.56	69
C22orf39	Physical association	Medium	0.56	36
C2orf68	Physical association	Medium	0.56	11
C3orf62	Physical association	Medium	0.56	10
C8orf48	Physical association	Medium	0.56	17
CAB39L	Physical association	Medium	0.56	3
CAPG	Physical association	Medium	0.56	2
CCDC185	Physical association	Medium	0.56	34
CCER1	Physical association	Medium	0.56	10
CCNC	Physical association	Medium	0.56	69
CD27	Physical association	Medium	0.56	4
CDC23	Physical association	Medium	0.56	69
CDS2	Physical association	Medium	0.56	29
CENPS	Physical association	Medium	0.56	5
CENPV	Physical association	Medium	0.56	14
CEP57	Physical association	Medium	0.56	12
CHMP7	Physical association	Medium	0.56	15
CIB1	Physical association	Medium	0.56	20
CLCN7	Physical association	Medium	0.56	12
CNPY3	Physical association	Medium	0.56	9
COA7	Physical association	Medium	0.56	11
COMMD2	Physical association	Medium	0.56	5
COX17	Physical association	Medium	0.56	4
CRACR2A	Physical association	Medium	0.56	31
CRLF3	Physical association	Medium	0.56	24
CSTA	Physical association	Medium	0.56	5
CTNNB1	Physical association	Medium	0.56	81
CTSC	Physical association	Medium	0.56	1
CXorf38	Physical association	Medium	0.56	10
CYFIP1	Physical association	Medium	0.56	10
CYTIP	Physical association	Medium	0.56	6
DAXX	Physical association	Medium	0.56	78
DCLRE1B	Physical association	Medium	0.56	8
DLK1	Physical association	Medium	0.56	1
DNTTIP1	Physical association	Medium	0.56	11
DPYSL4	Physical association	Medium	0.56	6
DRG2	Physical association	Medium	0.56	7
DTX3	Physical association	Medium	0.56	20
EBF1	Physical association	Medium	0.56	4
EIF3F	Physical association	Medium	0.56	42
EIF4ENIF1	Physical association	Medium	0.56	20
EPS8L2	Physical association	Medium	0.56	5
EXOC5	Physical association	Medium	0.56	46
EXOC6	Physical association	Medium	0.56	11
EXTL2	Physical association	Medium	0.56	3
FABP7	Physical association	Medium	0.56	5
FAF1	Physical association	Medium	0.56	7
FAM161A	Physical association	Medium	0.56	118
FAM221A	Physical association	Medium	0.56	10
FAM90A1	Physical association	Medium	0.56	128
FAM98C	Physical association	Medium	0.56	9
FAM9A	Physical association	Medium	0.56	47
FANCG	Physical association	Medium	0.56	35
FBLN5	Physical association	Medium	0.56	11
FHL5	Physical association	Medium	0.56	62
FKBP10	Physical association	Medium	0.56	2
FNTB	Physical association	Medium	0.56	9
FSTL1	Physical association	Medium	0.56	8
FZD4	Physical association	Medium	0.56	4
G2E3	Physical association	Medium	0.56	6
GFAP	Physical association	Medium	0.56	147
GFOD1	Physical association	Medium	0.56	17
GHITM	Physical association	Medium	0.56	7
GKN1	Physical association	Medium	0.56	13
GLI4	Physical association	Medium	0.56	3
GLYCTK	Physical association	Medium	0.56	48
GMCL2	Physical association	Medium	0.56	22
GNB2	Physical association	Medium	0.56	26
GPR141	Physical association	Medium	0.56	8
GPX7	Physical association	Medium	0.56	10
HAND1	Physical association	Medium	0.56	2
HAUS7	Physical association	Medium	0.56	11
HEXIM2	Physical association	Medium	0.56	38
HID1	Physical association	Medium	0.56	9
HMG20B	Physical association	Medium	0.56	16
HOXB7	Physical association	Medium	0.56	5
HOXC4	Physical association	Medium	0.56	22
HPCAL1	Physical association	Medium	0.56	31
HPRT1	Physical association	Medium	0.56	10
HS1BP3	Physical association	Medium	0.56	3
HSD3B2	Physical association	Medium	0.56	2
HSF2BP	Physical association	Medium	0.56	223
ID1	Physical association	Medium	0.56	13
ID3	Physical association	Medium	0.56	14
ID4	Physical association	Medium	0.56	1
IGFBP1	Physical association	Medium	0.56	3
IGFBP4	Physical association	Medium	0.56	10
IK	Physical association	Medium	0.56	21
ILKAP	Physical association	Medium	0.56	2
ING4	Physical association	Medium	0.56	11
IQGAP3	Physical association	Medium	0.56	6
IQUB	Physical association	Medium	0.56	56
ISCA2	Physical association	Medium	0.56	13
JPH3	Physical association	Medium	0.56	146
KAT2B	Physical association	Medium	0.56	12
KAT5	Physical association	Medium	0.56	180
KCTD17	Physical association	Medium	0.56	29
KEAP1	Physical association	Medium	0.56	53
KIF1A	Physical association	Medium	0.56	5
KLF6	Physical association	Medium	0.56	4
KLHL20	Physical association	Medium	0.56	31
KRCC1	Physical association	Medium	0.56	3
KRT33B	Physical association	Medium	0.56	65
KRTAP10-7	Physical association	Medium	0.56	239
KRTAP13-3	Physical association	Medium	0.56	58
LAPTM4A	Physical association	Medium	0.56	6
LCE2A	Physical association	Medium	0.56	43
LHX5	Physical association	Medium	0.56	17
LHX8	Physical association	Medium	0.56	28
LMNA	Physical association	Medium	0.56	53
LNX1	Physical association	Medium	0.56	333
LNX2	Physical association	Medium	0.56	63
LONRF2	Physical association	Medium	0.56	12
LOXL4	Physical association	Medium	0.56	15
LUC7L	Physical association	Medium	0.56	4
LYN	Physical association	Medium	0.56	29
MAB21L3	Physical association	Medium	0.56	24
MAGEC2	Physical association	Medium	0.56	11
MAOB	Physical association	Medium	0.56	14
MARCHF10	Physical association	Medium	0.56	5
MEOX1	Physical association	Medium	0.56	78
MESP1	Physical association	Medium	0.56	1
MIIP	Physical association	Medium	0.56	24
MPND	Physical association	Medium	0.56	15
MRFAP1	Physical association	Medium	0.56	34
MSX2	Physical association	Medium	0.56	26
MYLIP	Physical association	Medium	0.56	29
NDUFA8	Physical association	Medium	0.56	2
NDUFB7	Physical association	Medium	0.56	27
NDUFV2	Physical association	Medium	0.56	59
NEBL	Physical association	Medium	0.56	28
NELFCD	Physical association	Medium	0.56	5
NFE2	Physical association	Medium	0.56	6
NFKBIB	Physical association	Medium	0.56	7
NFX1	Physical association	Medium	0.56	5
NGFR	Physical association	Medium	0.56	8
NOD1	Physical association	Medium	0.56	11
NOL3	Physical association	Medium	0.56	5
NOS3	Physical association	Medium	0.56	40
NR1D2	Physical association	Medium	0.56	10
NSMCE2	Physical association	Medium	0.56	6
NUFIP2	Physical association	Medium	0.56	58
OBI1	Physical association	Medium	0.56	2
ODAD3	Physical association	Medium	0.56	16
ODF3L2	Physical association	Medium	0.56	10
OLIG3	Physical association	Medium	0.56	24
OTUB1	Physical association	Medium	0.56	43
PALM	Physical association	Medium	0.56	1
PARVG	Physical association	Medium	0.56	23
PCMTD2	Physical association	Medium	0.56	8
PHF5A	Physical association	Medium	0.56	4
PHF7	Physical association	Medium	0.56	4
PHKA2	Physical association	Medium	0.56	3
PIAS1	Physical association	Medium	0.56	38
PIK3R2	Physical association	Medium	0.56	21
PKM	Physical association	Medium	0.56	11
PLA2G10	Physical association	Medium	0.56	40
PLEKHG7	Physical association	Medium	0.56	18
PMF1	Physical association	Medium	0.56	13
PPARA	Physical association	Medium	0.56	18
PPP1CB	Physical association	Medium	0.56	42
PPP2R5A	Physical association	Medium	0.56	17
PPTC7	Physical association	Medium	0.56	6
PRIM2	Physical association	Medium	0.56	2
PRKAB2	Physical association	Medium	0.56	126
PRPF18	Physical association	Medium	0.56	63
PRR15	Physical association	Medium	0.56	1
PSMB10	Physical association	Medium	0.56	7
RAB11B	Physical association	Medium	0.56	9
RAN	Physical association	Medium	0.56	86
RCHY1	Physical association	Medium	0.56	17
RCN1	Physical association	Medium	0.56	19
REX1BD	Physical association	Medium	0.56	13
RGS17	Physical association	Medium	0.56	34
RHEBL1	Physical association	Medium	0.56	7
RHOJ	Physical association	Medium	0.56	16
RHPN1	Physical association	Medium	0.56	15
RILP	Physical association	Medium	0.56	8
RIN1	Physical association	Medium	0.56	38
RING1	Physical association	Medium	0.56	23
RIPPLY2	Physical association	Medium	0.56	9
RMND5B	Physical association	Medium	0.56	13
RNF10	Physical association	Medium	0.56	13
RNF138	Physical association	Medium	0.56	18
RNF183	Physical association	Medium	0.56	30
RNF208	Physical association	Medium	0.56	20
RNF34	Physical association	Medium	0.56	8
RPS4X	Physical association	Medium	0.56	13
RPUSD1	Physical association	Medium	0.56	1
RUFY4	Physical association	Medium	0.56	9
RXRG	Physical association	Medium	0.56	13
RYBP	Physical association	Medium	0.56	44
SCNM1	Physical association	Medium	0.56	148
SDC2	Physical association	Medium	0.56	7
SDCBP	Physical association	Medium	0.56	240
SELE	Physical association	Medium	0.56	3
SENP3	Physical association	Medium	0.56	8
SHLD1	Physical association	Medium	0.56	6
SKIC8	Physical association	Medium	0.56	30
SKIL	Physical association	Medium	0.56	17
SLFN12	Physical association	Medium	0.56	9
SMARCB1	Physical association	Medium	0.56	33
SMIM14	Physical association	Medium	0.56	5
SNRNP48	Physical association	Medium	0.56	3
SNW1	Physical association	Medium	0.56	89
SOCS4	Physical association	Medium	0.56	14
SPG21	Physical association	Medium	0.56	129
SPRED2	Physical association	Medium	0.56	38
SPRY4	Physical association	Medium	0.56	30
SSX2	Physical association	Medium	0.56	9
SSX2B	Physical association	Medium	0.56	9
STK36	Physical association	Medium	0.56	7
STUB1	Physical association	Medium	0.56	54
STX11	Physical association	Medium	0.56	80
STX19	Physical association	Medium	0.56	16
TADA3	Physical association	Medium	0.56	13
TASOR2	Physical association	Medium	0.56	34
TCEAL8	Physical association	Medium	0.56	8
TES	Physical association	Medium	0.56	3
THEM4	Physical association	Medium	0.56	6
TIMM8A	Physical association	Medium	0.56	13
TIPIN	Physical association	Medium	0.56	4
TMEM61	Physical association	Medium	0.56	11
TNIP3	Physical association	Medium	0.56	26
TP53BP1	Physical association	Medium	0.56	71
TRAF5	Physical association	Medium	0.56	35
TRIB2	Physical association	Medium	0.56	2
TRIM42	Physical association	Medium	0.56	112
TSNAX	Physical association	Medium	0.56	36
TXN	Physical association	Medium	0.56	26
UBR1	Physical association	Medium	0.56	5
UBR4	Physical association	Medium	0.56	1
UCHL3	Physical association	Medium	0.56	1
VPS37A	Physical association	Medium	0.56	18
VSNL1	Physical association	Medium	0.56	12
WASF2	Physical association	Medium	0.56	4
WDR83	Physical association	Medium	0.56	30
YY1	Physical association	Medium	0.56	47
ZBTB25	Physical association	Medium	0.56	24
ZFP2	Physical association	Medium	0.56	10
ZFPM2	Physical association	Medium	0.56	4
ZIK1	Physical association	Medium	0.56	1
ZKSCAN5	Physical association	Medium	0.56	5
ZKSCAN8	Physical association	Medium	0.56	14
ZMYND12	Physical association	Medium	0.56	66
ZNF124	Physical association	Medium	0.56	45
ZNF138	Physical association	Medium	0.56	16
ZNF165	Physical association	Medium	0.56	31
ZNF20	Physical association	Medium	0.56	43
ZNF23	Physical association	Medium	0.56	14
ZNF239	Physical association	Medium	0.56	7
ZNF286A	Physical association	Medium	0.56	13
ZNF345	Physical association	Medium	0.56	4
ZNF366	Physical association	Medium	0.56	22
ZNF408	Physical association	Medium	0.56	51
ZNF414	Physical association	Medium	0.56	42
ZNF417	Physical association	Medium	0.56	140
ZNF436	Physical association	Medium	0.56	19
ZNF460	Physical association	Medium	0.56	6
ZNF496	Physical association	Medium	0.56	11
ZNF497	Physical association	Medium	0.56	41
ZNF500	Physical association	Medium	0.56	8
ZNF524	Physical association	Medium	0.56	22
ZNF566	Physical association	Medium	0.56	4
ZNF57	Physical association	Medium	0.56	14
ZNF572	Physical association	Medium	0.56	58
ZNF581	Physical association	Medium	0.56	82
ZNF587	Physical association	Medium	0.56	102
ZNF597	Physical association	Medium	0.56	8
ZNF649	Physical association	Medium	0.56	3
ZNF655	Physical association	Medium	0.56	117
ZNF670	Physical association	Medium	0.56	19
ZNF696	Physical association	Medium	0.56	30
ZNF774	Physical association	Medium	0.56	68
ZSCAN12	Physical association	Medium	0.56	20
ZSCAN16	Physical association	Medium	0.56	8
ZSCAN22	Physical association	Medium	0.56	27
ZSCAN9	Physical association	Medium	0.56	21
ZDHHC17	Physical association	Medium	0.51	30
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
SPRED1 is not a metabolic protein