Protein interactions for HSF2BP - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HSF2BP
Gene descriptionⁱ Full gene name according to HGNC.	Heat shock transcription factor 2 binding protein
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Testis - Spermatogenesis (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enriched (testis)
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.88
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Nucleoplasm In addition localized to the Cytosol
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Testis - Spermatogenesis

Field

Cluster

Pathway

Number of interactions:

223

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
CDC73	Physical association	High	0.67	30
ACTN3	Physical association	Medium	0.56	38
ANAPC16	Physical association	Medium	0.56	3
ANKRD55	Physical association	Medium	0.56	17
ARHGAP45	Physical association	Medium	0.56	8
ARHGEF3	Physical association	Medium	0.56	7
ARHGEF4	Physical association	Medium	0.56	1
ARHGEF5	Physical association	Medium	0.56	18
ARHGEF6	Physical association	Medium	0.56	13
ATOSB	Physical association	Medium	0.56	50
BARD1	Physical association	Medium	0.56	20
BAX	Physical association	Medium	0.56	12
BAZ2B	Physical association	Medium	0.56	9
BCAS2	Physical association	Medium	0.56	49
BEX2	Physical association	Medium	0.56	67
BLK	Physical association	Medium	0.56	22
BMI1	Physical association	Medium	0.56	18
BYSL	Physical association	Medium	0.56	119
C10orf88	Physical association	Medium	0.56	9
C18orf54	Physical association	Medium	0.56	7
C1orf35	Physical association	Medium	0.56	32
C1orf94	Physical association	Medium	0.56	69
C2CD6	Physical association	Medium	0.56	44
C4orf46	Physical association	Medium	0.56	7
C5orf49	Physical association	Medium	0.56	4
C7orf31	Physical association	Medium	0.56	15
C9orf24	Physical association	Medium	0.56	22
CBX8	Physical association	Medium	0.56	78
CCDC113	Physical association	Medium	0.56	1
CCDC116	Physical association	Medium	0.56	24
CCDC120	Physical association	Medium	0.56	90
CCDC13	Physical association	Medium	0.56	37
CCDC146	Physical association	Medium	0.56	42
CCDC185	Physical association	Medium	0.56	34
CDC37	Physical association	Medium	0.56	124
CDCA7L	Physical association	Medium	0.56	52
CDR2L	Physical association	Medium	0.56	49
CDYL2	Physical association	Medium	0.56	6
CEP55	Physical association	Medium	0.56	56
CKS1B	Physical association	Medium	0.56	43
CLIP4	Physical association	Medium	0.56	10
CNNM1	Physical association	Medium	0.56	3
CNNM3	Physical association	Medium	0.56	59
CNOT2	Physical association	Medium	0.56	24
COIL	Physical association	Medium	0.56	35
CTSZ	Physical association	Medium	0.56	16
CTTNBP2	Physical association	Medium	0.56	6
CTTNBP2NL	Physical association	Medium	0.56	10
CWF19L2	Physical association	Medium	0.56	65
DCDC2B	Physical association	Medium	0.56	10
DMAP1	Physical association	Medium	0.56	27
DMRT3	Physical association	Medium	0.56	65
DPF2	Physical association	Medium	0.56	10
DUSP13	Physical association	Medium	0.56	9
EAF1	Physical association	Medium	0.56	41
EIF3D	Physical association	Medium	0.56	27
ELOA2	Physical association	Medium	0.56	11
EMD	Physical association	Medium	0.56	72
ENKD1	Physical association	Medium	0.56	159
EPHB3	Physical association	Medium	0.56	2
EPM2AIP1	Physical association	Medium	0.56	40
FAM110A	Physical association	Medium	0.56	41
FAM110B	Physical association	Medium	0.56	3
FAM161B	Physical association	Medium	0.56	54
FAM228A	Physical association	Medium	0.56	15
FAM90A1	Physical association	Medium	0.56	128
FHL2	Physical association	Medium	0.56	96
FHL3	Physical association	Medium	0.56	103
FLYWCH1	Physical association	Medium	0.56	8
FUT9	Physical association	Medium	0.56	3
GAS2L2	Physical association	Medium	0.56	29
GAS8	Physical association	Medium	0.56	97
GCM2	Physical association	Medium	0.56	22
GEM	Physical association	Medium	0.56	88
GGN	Physical association	Medium	0.56	14
GNL3L	Physical association	Medium	0.56	13
GOLGA1	Physical association	Medium	0.56	12
GPANK1	Physical association	Medium	0.56	65
GPBP1	Physical association	Medium	0.56	11
GPKOW	Physical association	Medium	0.56	40
GPSM3	Physical association	Medium	0.56	38
H2AC25	Physical association	Medium	0.56	3
HASPIN	Physical association	Medium	0.56	3
HEXIM2	Physical association	Medium	0.56	38
HEY2	Physical association	Medium	0.56	17
HNRNPH2	Physical association	Medium	0.56	6
HOXB5	Physical association	Medium	0.56	47
HOXC8	Physical association	Medium	0.56	74
HSF2	Physical association	Medium	0.56	8
IER2	Physical association	Medium	0.56	2
INO80B	Physical association	Medium	0.56	49
INPP5J	Physical association	Medium	0.56	15
INSYN2A	Physical association	Medium	0.56	2
IPMK	Physical association	Medium	0.56	1
IQCC	Physical association	Medium	0.56	3
ITGB3BP	Physical association	Medium	0.56	28
KANK2	Physical association	Medium	0.56	151
KAT5	Physical association	Medium	0.56	180
KIAA0408	Physical association	Medium	0.56	24
KIF5B	Physical association	Medium	0.56	17
KIF9	Physical association	Medium	0.56	42
KLF4	Physical association	Medium	0.56	9
L3MBTL2	Physical association	Medium	0.56	36
LAGE3	Physical association	Medium	0.56	19
LEP	Physical association	Medium	0.56	1
LGALS4	Physical association	Medium	0.56	6
LMO4	Physical association	Medium	0.56	85
LNX1	Physical association	Medium	0.56	333
LRRC56	Physical association	Medium	0.56	6
LRRN4	Physical association	Medium	0.56	5
LUZP4	Physical association	Medium	0.56	19
MAGED1	Physical association	Medium	0.56	79
MAGOHB	Physical association	Medium	0.56	56
MARCHF7	Physical association	Medium	0.56	5
MFAP1	Physical association	Medium	0.56	79
MISP	Physical association	Medium	0.56	44
MKRN3	Physical association	Medium	0.56	118
MVB12A	Physical association	Medium	0.56	2
MYOZ3	Physical association	Medium	0.56	44
NAB2	Physical association	Medium	0.56	62
NCK2	Physical association	Medium	0.56	113
NFIL3	Physical association	Medium	0.56	9
NHSL2	Physical association	Medium	0.56	19
NME4	Physical association	Medium	0.56	43
NPPA	Physical association	Medium	0.56	4
NTAQ1	Physical association	Medium	0.56	302
NUDT10	Physical association	Medium	0.56	6
NXF1	Physical association	Medium	0.56	62
ODF3B	Physical association	Medium	0.56	8
ODF3L2	Physical association	Medium	0.56	10
OPTN	Physical association	Medium	0.56	127
P2RX7	Physical association	Medium	0.56	10
PAK6	Physical association	Medium	0.56	6
PAPSS2	Physical association	Medium	0.56	3
PARD6B	Physical association	Medium	0.56	19
PDLIM7	Physical association	Medium	0.56	31
PICK1	Physical association	Medium	0.56	275
PKD2	Physical association	Medium	0.56	12
PKN1	Physical association	Medium	0.56	59
PNMA5	Physical association	Medium	0.56	53
POGZ	Physical association	Medium	0.56	58
POMC	Physical association	Medium	0.56	13
PPM1K	Physical association	Medium	0.56	5
PPP1R18	Physical association	Medium	0.56	68
PRPF18	Physical association	Medium	0.56	63
PRPF3	Physical association	Medium	0.56	35
PRPF31	Physical association	Medium	0.56	118
PRR5L	Physical association	Medium	0.56	13
PSMA1	Physical association	Medium	0.56	135
PSTPIP1	Physical association	Medium	0.56	42
RAB11FIP2	Physical association	Medium	0.56	10
RAB36	Physical association	Medium	0.56	1
RAB3IL1	Physical association	Medium	0.56	24
RAD51D	Physical association	Medium	0.56	35
RBM17	Physical association	Medium	0.56	21
RBM41	Physical association	Medium	0.56	23
RBM48	Physical association	Medium	0.56	21
REXO4	Physical association	Medium	0.56	3
RIBC1	Physical association	Medium	0.56	21
RIN1	Physical association	Medium	0.56	38
RNF135	Physical association	Medium	0.56	4
RNF169	Physical association	Medium	0.56	3
RPS28	Physical association	Medium	0.56	9
RTP5	Physical association	Medium	0.56	49
SART1	Physical association	Medium	0.56	10
SAXO1	Physical association	Medium	0.56	39
SCNM1	Physical association	Medium	0.56	148
SDCBP	Physical association	Medium	0.56	240
SELENOV	Physical association	Medium	0.56	9
SEMA4C	Physical association	Medium	0.56	14
SEPTIN1	Physical association	Medium	0.56	17
SH2D4A	Physical association	Medium	0.56	63
SHISA6	Physical association	Medium	0.56	20
SLAIN1	Physical association	Medium	0.56	31
SLC6A1	Physical association	Medium	0.56	2
SMARCD1	Physical association	Medium	0.56	104
SMG9	Physical association	Medium	0.56	32
SNAPC1	Physical association	Medium	0.56	5
SNW1	Physical association	Medium	0.56	89
SNX18	Physical association	Medium	0.56	14
SPATA22	Physical association	Medium	0.56	16
SPG7	Physical association	Medium	0.56	17
SPRED1	Physical association	Medium	0.56	308
SPRY1	Physical association	Medium	0.56	59
SYNGAP1	Physical association	Medium	0.56	10
TAB2	Physical association	Medium	0.56	16
TAGAP	Physical association	Medium	0.56	1
TASOR2	Physical association	Medium	0.56	34
TBC1D1	Physical association	Medium	0.56	24
TCEA2	Physical association	Medium	0.56	88
TCF19	Physical association	Medium	0.56	12
TEPSIN	Physical association	Medium	0.56	101
TFIP11	Physical association	Medium	0.56	179
THAP6	Physical association	Medium	0.56	13
TMEFF2	Physical association	Medium	0.56	5
TMSB4X	Physical association	Medium	0.56	10
TNS4	Physical association	Medium	0.56	10
TRAF5	Physical association	Medium	0.56	35
TSEN15	Physical association	Medium	0.56	21
TSGA10IP	Physical association	Medium	0.56	83
TSHZ3	Physical association	Medium	0.56	24
TTC9C	Physical association	Medium	0.56	14
TULP3	Physical association	Medium	0.56	15
UPRT	Physical association	Medium	0.56	8
VEZF1	Physical association	Medium	0.56	40
VPS72	Physical association	Medium	0.56	5
WASF1	Physical association	Medium	0.56	15
YJU2B	Physical association	Medium	0.56	19
ZBTB16	Physical association	Medium	0.56	43
ZBTB42	Physical association	Medium	0.56	38
ZCWPW2	Physical association	Medium	0.56	2
ZNF185	Physical association	Medium	0.56	5
ZNF417	Physical association	Medium	0.56	140
ZNF511	Physical association	Medium	0.56	12
ZNF564	Physical association	Medium	0.56	30
ZNF581	Physical association	Medium	0.56	82
ZNF587	Physical association	Medium	0.56	102
ZNF648	Physical association	Medium	0.56	50
ZNF688	Physical association	Medium	0.56	28
ZNF774	Physical association	Medium	0.56	68
ZNF835	Physical association	Medium	0.56	54
ZNF84	Physical association	Medium	0.56	3
ZNF844	Physical association	Medium	0.56	11
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
HSF2BP is not a metabolic protein