Protein interactions for CCDC120 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CCDC120
Gene descriptionⁱ Full gene name according to HGNC.	Coiled-coil domain containing 120
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Cancer-related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Squamous epithelium - Keratinization (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enhanced (esophagus, skin)
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.51
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Mitochondria
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Squamous epithelium - Keratinization

Field

Cluster

Pathway

Number of interactions:

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
CEP170	Direct interaction	High	0.76	12
NIN	Direct interaction	High	0.68	3
CYTH1	Physical association	High	0.67	12
CYTH2	Physical association	High	0.67	6
ODF2	Physical association	Medium	0.6	1
AKAP8L	Physical association	Medium	0.56	49
ARID5A	Physical association	Medium	0.56	94
ATP23	Physical association	Medium	0.56	22
BCAS2	Physical association	Medium	0.56	49
BLZF1	Physical association	Medium	0.56	84
C1orf109	Physical association	Medium	0.56	121
CALCOCO2	Physical association	Medium	0.56	117
CCDC102B	Physical association	Medium	0.56	87
CCDC13	Physical association	Medium	0.56	37
CDR2	Physical association	Medium	0.56	68
CEP55	Physical association	Medium	0.56	56
CKS1B	Physical association	Medium	0.56	43
CNFN	Physical association	Medium	0.56	10
COG6	Physical association	Medium	0.56	49
CYSRT1	Physical association	Medium	0.56	396
CYTH4	Physical association	Medium	0.56	14
EFHC2	Physical association	Medium	0.56	79
EIF3F	Physical association	Medium	0.56	42
FGFR3	Physical association	Medium	0.56	192
FOS	Physical association	Medium	0.56	48
FOSL1	Physical association	Medium	0.56	17
FSD2	Physical association	Medium	0.56	73
GAS2L2	Physical association	Medium	0.56	29
GFAP	Physical association	Medium	0.56	147
GOLGA2	Physical association	Medium	0.56	349
GOLGA6L9	Physical association	Medium	0.56	177
GPRASP3	Physical association	Medium	0.56	49
HNRNPH1	Physical association	Medium	0.56	30
HOMER3	Physical association	Medium	0.56	65
HRAS	Physical association	Medium	0.56	87
HSF2BP	Physical association	Medium	0.56	223
HTT	Physical association	Medium	0.56	665
IFT88	Physical association	Medium	0.56	23
IHO1	Physical association	Medium	0.56	62
INTS11	Physical association	Medium	0.56	27
KASH5	Physical association	Medium	0.56	96
KRT31	Physical association	Medium	0.56	284
KRT34	Physical association	Medium	0.56	201
KRT35	Physical association	Medium	0.56	69
KRT38	Physical association	Medium	0.56	57
KRTAP13-3	Physical association	Medium	0.56	58
KRTAP19-1	Physical association	Medium	0.56	36
KRTAP6-1	Physical association	Medium	0.56	70
KRTAP6-2	Physical association	Medium	0.56	136
LMNB2	Physical association	Medium	0.56	22
LMO4	Physical association	Medium	0.56	85
LZTS1	Physical association	Medium	0.56	73
MAGED1	Physical association	Medium	0.56	79
MED11	Physical association	Medium	0.56	11
METTL27	Physical association	Medium	0.56	41
MIIP	Physical association	Medium	0.56	24
MIPOL1	Physical association	Medium	0.56	58
MKRN3	Physical association	Medium	0.56	118
MRPL38	Physical association	Medium	0.56	16
MYOG	Physical association	Medium	0.56	27
NCK2	Physical association	Medium	0.56	113
NOTO	Physical association	Medium	0.56	24
NXF1	Physical association	Medium	0.56	62
PECAM1	Physical association	Medium	0.56	58
PLA2G10	Physical association	Medium	0.56	40
PLAGL2	Physical association	Medium	0.56	36
PLEKHG4	Physical association	Medium	0.56	50
POU2AF1	Physical association	Medium	0.56	30
PRDM6	Physical association	Medium	0.56	48
PRPH	Physical association	Medium	0.56	57
RAB5A	Physical association	Medium	0.56	19
RABEP1	Physical association	Medium	0.56	39
RERE	Physical association	Medium	0.56	5
RINT1	Physical association	Medium	0.56	68
RUSC1	Physical association	Medium	0.56	71
SORBS3	Physical association	Medium	0.56	87
STX11	Physical association	Medium	0.56	80
TFIP11	Physical association	Medium	0.56	179
TP53BP1	Physical association	Medium	0.56	71
TRAF1	Physical association	Medium	0.56	166
TRIM42	Physical association	Medium	0.56	112
TRIP6	Physical association	Medium	0.56	90
TSGA10IP	Physical association	Medium	0.56	83
VIM	Physical association	Medium	0.56	86
ZIM2	Physical association	Medium	0.56	26
ZMAT5	Physical association	Medium	0.56	16
ZNF417	Physical association	Medium	0.56	140
ZNF648	Physical association	Medium	0.56	50
ZRANB1	Physical association	Medium	0.56	112
MDFI	Physical association	Medium	0.55	277
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
CCDC120 is not a metabolic protein