Protein interactions for CYSRT1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CYSRT1
Gene descriptionⁱ Full gene name according to HGNC.	Cysteine rich tail 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Not detected - no cluster assigned
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enriched (esophagus)
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.84
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Nuclear speckles In addition localized to the Vesicles, Midbody
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria

Field

Cluster

Pathway

Number of interactions:

396

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
KRTAP1-3	Physical association	High	0.63	140
KPRP	Physical association	High	0.6	80
KRTAP4-4	Physical association	High	0.6	56
KRTAP9-8	Physical association	High	0.6	72
LCE2C	Physical association	High	0.6	71
LCE3A	Physical association	High	0.6	54
LCE4A	Physical association	High	0.6	63
PLLP	Physical association	High	0.6	33
PRKAB2	Physical association	High	0.6	126
ZNF786	Physical association	High	0.6	9
A1CF	Physical association	Medium	0.56	16
ACY3	Physical association	Medium	0.56	15
ADAMTSL3	Physical association	Medium	0.56	13
AGXT	Physical association	Medium	0.56	28
ALDH3B1	Physical association	Medium	0.56	15
ALPP	Physical association	Medium	0.56	30
AQP1	Physical association	Medium	0.56	106
AREG	Physical association	Medium	0.56	3
ARHGAP9	Physical association	Medium	0.56	10
ARID5A	Physical association	Medium	0.56	94
ASTL	Physical association	Medium	0.56	1
ATOSB	Physical association	Medium	0.56	50
ATPAF2	Physical association	Medium	0.56	57
AVPI1	Physical association	Medium	0.56	29
B4GALT7	Physical association	Medium	0.56	5
BAG3	Physical association	Medium	0.56	58
BAHD1	Physical association	Medium	0.56	54
BAIAP2L1	Physical association	Medium	0.56	4
BEX1	Physical association	Medium	0.56	12
BEX2	Physical association	Medium	0.56	67
BLCAP	Physical association	Medium	0.56	14
BMP7	Physical association	Medium	0.56	13
C11orf87	Physical association	Medium	0.56	18
C22orf39	Physical association	Medium	0.56	36
C4orf45	Physical association	Medium	0.56	16
C7orf31	Physical association	Medium	0.56	15
C9orf24	Physical association	Medium	0.56	22
CACNA1S	Physical association	Medium	0.56	4
CARD10	Physical association	Medium	0.56	83
CARHSP1	Physical association	Medium	0.56	11
CATIP	Physical association	Medium	0.56	14
CATSPER1	Physical association	Medium	0.56	95
CBLL2	Physical association	Medium	0.56	7
CCDC120	Physical association	Medium	0.56	90
CCER1	Physical association	Medium	0.56	10
CD300LG	Physical association	Medium	0.56	6
CDKL3	Physical association	Medium	0.56	22
CELF5	Physical association	Medium	0.56	19
CERCAM	Physical association	Medium	0.56	28
CERK	Physical association	Medium	0.56	19
CFAP206	Physical association	Medium	0.56	46
CFP	Physical association	Medium	0.56	22
CHCHD2	Physical association	Medium	0.56	24
CHCHD3	Physical association	Medium	0.56	37
CHIC2	Physical association	Medium	0.56	53
CHRD	Physical association	Medium	0.56	40
CLDN2	Physical association	Medium	0.56	16
CLEC18A	Physical association	Medium	0.56	5
CNNM3	Physical association	Medium	0.56	59
CNTF	Physical association	Medium	0.56	14
COA5	Physical association	Medium	0.56	3
COL8A1	Physical association	Medium	0.56	51
COMP	Physical association	Medium	0.56	7
CPT2	Physical association	Medium	0.56	2
CRCT1	Physical association	Medium	0.56	46
CRH	Physical association	Medium	0.56	11
CRY2	Physical association	Medium	0.56	29
CRYBA1	Physical association	Medium	0.56	18
CRYBA2	Physical association	Medium	0.56	21
CSF1	Physical association	Medium	0.56	7
CST2	Physical association	Medium	0.56	7
CST9L	Physical association	Medium	0.56	6
CTRC	Physical association	Medium	0.56	12
CTSG	Physical association	Medium	0.56	4
CTSZ	Physical association	Medium	0.56	16
DCDC2B	Physical association	Medium	0.56	10
DDX43	Physical association	Medium	0.56	2
DMRT3	Physical association	Medium	0.56	65
DNAJA3	Physical association	Medium	0.56	9
DNASE1L3	Physical association	Medium	0.56	2
DOCK2	Physical association	Medium	0.56	36
DVL3	Physical association	Medium	0.56	120
ECE1	Physical association	Medium	0.56	5
ECM1	Physical association	Medium	0.56	27
EFEMP1	Physical association	Medium	0.56	27
EFEMP2	Physical association	Medium	0.56	83
EMC7	Physical association	Medium	0.56	6
ENKD1	Physical association	Medium	0.56	159
ERH	Physical association	Medium	0.56	9
ETNK2	Physical association	Medium	0.56	4
EVA1B	Physical association	Medium	0.56	6
FAM221A	Physical association	Medium	0.56	10
FAM221B	Physical association	Medium	0.56	12
FAM222B	Physical association	Medium	0.56	25
FAM83A	Physical association	Medium	0.56	22
FAM90A1	Physical association	Medium	0.56	128
FANCL	Physical association	Medium	0.56	36
FARS2	Physical association	Medium	0.56	56
FASLG	Physical association	Medium	0.56	28
FBXW5	Physical association	Medium	0.56	21
FEZF1	Physical association	Medium	0.56	6
FHL3	Physical association	Medium	0.56	103
FOXD2	Physical association	Medium	0.56	14
FOXD4L1	Physical association	Medium	0.56	17
FOXD4L3	Physical association	Medium	0.56	14
FOXH1	Physical association	Medium	0.56	48
FRS3	Physical association	Medium	0.56	77
FRZB	Physical association	Medium	0.56	1
FZD10	Physical association	Medium	0.56	6
GARIN6	Physical association	Medium	0.56	19
GAS8	Physical association	Medium	0.56	97
GATA2	Physical association	Medium	0.56	24
GATA5	Physical association	Medium	0.56	7
GCSAM	Physical association	Medium	0.56	4
GEM	Physical association	Medium	0.56	88
GGN	Physical association	Medium	0.56	14
GLB1L2	Physical association	Medium	0.56	2
GLP1R	Physical association	Medium	0.56	10
GNG13	Physical association	Medium	0.56	21
GPANK1	Physical association	Medium	0.56	65
GPS2	Physical association	Medium	0.56	31
GRN	Physical association	Medium	0.56	216
GSTP1	Physical association	Medium	0.56	21
HBZ	Physical association	Medium	0.56	18
HDHD3	Physical association	Medium	0.56	11
HEY2	Physical association	Medium	0.56	17
HHEX	Physical association	Medium	0.56	23
HLX	Physical association	Medium	0.56	9
HOXB5	Physical association	Medium	0.56	47
HOXB9	Physical association	Medium	0.56	42
HOXC8	Physical association	Medium	0.56	74
HOXC9	Physical association	Medium	0.56	14
HR	Physical association	Medium	0.56	15
HRG	Physical association	Medium	0.56	2
HSBP1	Physical association	Medium	0.56	15
HSD3B7	Physical association	Medium	0.56	42
HSPA12B	Physical association	Medium	0.56	10
HSPD1	Physical association	Medium	0.56	35
HYAL2	Physical association	Medium	0.56	12
ICAM1	Physical association	Medium	0.56	7
INCA1	Physical association	Medium	0.56	204
INO80B	Physical association	Medium	0.56	49
INS	Physical association	Medium	0.56	4
IQUB	Physical association	Medium	0.56	56
ISYNA1	Physical association	Medium	0.56	3
ITGB2	Physical association	Medium	0.56	21
ITGB5	Physical association	Medium	0.56	20
JOSD1	Physical association	Medium	0.56	24
KCNS2	Physical association	Medium	0.56	3
KLHL38	Physical association	Medium	0.56	72
KLK8	Physical association	Medium	0.56	13
KRT20	Physical association	Medium	0.56	32
KRT31	Physical association	Medium	0.56	284
KRT33B	Physical association	Medium	0.56	65
KRT34	Physical association	Medium	0.56	201
KRT81	Physical association	Medium	0.56	22
KRT83	Physical association	Medium	0.56	31
KRT85	Physical association	Medium	0.56	22
KRT86	Physical association	Medium	0.56	38
KRTAP1-1	Physical association	Medium	0.56	150
KRTAP1-5	Physical association	Medium	0.56	32
KRTAP10-10	Physical association	Medium	0.56	18
KRTAP10-11	Physical association	Medium	0.56	31
KRTAP10-5	Physical association	Medium	0.56	115
KRTAP10-7	Physical association	Medium	0.56	239
KRTAP10-8	Physical association	Medium	0.56	325
KRTAP10-9	Physical association	Medium	0.56	182
KRTAP11-1	Physical association	Medium	0.56	83
KRTAP12-1	Physical association	Medium	0.56	50
KRTAP12-2	Physical association	Medium	0.56	97
KRTAP12-3	Physical association	Medium	0.56	117
KRTAP12-4	Physical association	Medium	0.56	41
KRTAP13-2	Physical association	Medium	0.56	57
KRTAP13-3	Physical association	Medium	0.56	58
KRTAP13-4	Physical association	Medium	0.56	6
KRTAP15-1	Physical association	Medium	0.56	53
KRTAP19-1	Physical association	Medium	0.56	36
KRTAP19-2	Physical association	Medium	0.56	32
KRTAP19-3	Physical association	Medium	0.56	11
KRTAP19-5	Physical association	Medium	0.56	82
KRTAP19-6	Physical association	Medium	0.56	49
KRTAP19-7	Physical association	Medium	0.56	71
KRTAP2-4	Physical association	Medium	0.56	77
KRTAP26-1	Physical association	Medium	0.56	73
KRTAP3-1	Physical association	Medium	0.56	61
KRTAP3-3	Physical association	Medium	0.56	60
KRTAP4-11	Physical association	Medium	0.56	61
KRTAP4-12	Physical association	Medium	0.56	74
KRTAP4-2	Physical association	Medium	0.56	102
KRTAP4-5	Physical association	Medium	0.56	54
KRTAP5-11	Physical association	Medium	0.56	49
KRTAP5-3	Physical association	Medium	0.56	39
KRTAP5-6	Physical association	Medium	0.56	73
KRTAP5-7	Physical association	Medium	0.56	50
KRTAP5-9	Physical association	Medium	0.56	166
KRTAP6-1	Physical association	Medium	0.56	70
KRTAP6-2	Physical association	Medium	0.56	136
KRTAP8-1	Physical association	Medium	0.56	76
KRTAP9-2	Physical association	Medium	0.56	123
KRTAP9-3	Physical association	Medium	0.56	103
KSR2	Physical association	Medium	0.56	4
LAGE3	Physical association	Medium	0.56	19
LCE1A	Physical association	Medium	0.56	59
LCE1B	Physical association	Medium	0.56	69
LCE1C	Physical association	Medium	0.56	55
LCE1D	Physical association	Medium	0.56	47
LCE1E	Physical association	Medium	0.56	52
LCE1F	Physical association	Medium	0.56	61
LCE2A	Physical association	Medium	0.56	43
LCE2B	Physical association	Medium	0.56	55
LCE2D	Physical association	Medium	0.56	51
LCE3B	Physical association	Medium	0.56	34
LCE3C	Physical association	Medium	0.56	46
LCE3D	Physical association	Medium	0.56	44
LCE3E	Physical association	Medium	0.56	46
LCE5A	Physical association	Medium	0.56	53
LENG8	Physical association	Medium	0.56	35
LGALS9C	Physical association	Medium	0.56	23
LMNTD2	Physical association	Medium	0.56	17
LMO4	Physical association	Medium	0.56	85
LNX1	Physical association	Medium	0.56	333
LONRF1	Physical association	Medium	0.56	77
LONRF3	Physical association	Medium	0.56	8
LRFN4	Physical association	Medium	0.56	8
LRRC41	Physical association	Medium	0.56	6
LRRN4	Physical association	Medium	0.56	5
LYVE1	Physical association	Medium	0.56	21
MACROH2A1	Physical association	Medium	0.56	11
MAPKBP1	Physical association	Medium	0.56	48
MCRS1	Physical association	Medium	0.56	97
MED25	Physical association	Medium	0.56	21
MFSD13A	Physical association	Medium	0.56	3
MIIP	Physical association	Medium	0.56	24
MKRN3	Physical association	Medium	0.56	118
MRPL23	Physical association	Medium	0.56	5
MRPL40	Physical association	Medium	0.56	7
MSRB1	Physical association	Medium	0.56	4
MT1M	Physical association	Medium	0.56	6
MTA1	Physical association	Medium	0.56	23
MTNR1A	Physical association	Medium	0.56	7
MXD3	Physical association	Medium	0.56	10
MYPOP	Physical association	Medium	0.56	33
NDUFA9	Physical association	Medium	0.56	9
NDUFAF3	Physical association	Medium	0.56	13
NDUFV1	Physical association	Medium	0.56	17
NEU2	Physical association	Medium	0.56	2
NKD1	Physical association	Medium	0.56	11
NMU	Physical association	Medium	0.56	14
NOTCH2NLC	Physical association	Medium	0.56	178
NPBWR2	Physical association	Medium	0.56	15
NPDC1	Physical association	Medium	0.56	27
NPPB	Physical association	Medium	0.56	7
NR4A3	Physical association	Medium	0.56	30
NTAQ1	Physical association	Medium	0.56	302
NTN4	Physical association	Medium	0.56	8
NUBP2	Physical association	Medium	0.56	10
NUFIP2	Physical association	Medium	0.56	58
ODF3L1	Physical association	Medium	0.56	2
OLIG3	Physical association	Medium	0.56	24
OR7A17	Physical association	Medium	0.56	2
OTOS	Physical association	Medium	0.56	3
OTX1	Physical association	Medium	0.56	118
P2RX7	Physical association	Medium	0.56	10
PGAP6	Physical association	Medium	0.56	9
PITX1	Physical association	Medium	0.56	50
PKD2	Physical association	Medium	0.56	12
PKN1	Physical association	Medium	0.56	59
PLA2G10	Physical association	Medium	0.56	40
POLD1	Physical association	Medium	0.56	10
POU4F2	Physical association	Medium	0.56	62
PPP1CB	Physical association	Medium	0.56	42
PPY	Physical association	Medium	0.56	1
PRF1	Physical association	Medium	0.56	3
PRKAA2	Physical association	Medium	0.56	78
PROC	Physical association	Medium	0.56	1
PROP1	Physical association	Medium	0.56	40
PRPF31	Physical association	Medium	0.56	118
PRR30	Physical association	Medium	0.56	3
PRR35	Physical association	Medium	0.56	57
PTGDS	Physical association	Medium	0.56	10
PTPMT1	Physical association	Medium	0.56	25
PVR	Physical association	Medium	0.56	52
QRICH1	Physical association	Medium	0.56	36
R3HDM2	Physical association	Medium	0.56	15
RAB3IL1	Physical association	Medium	0.56	24
RAMAC	Physical association	Medium	0.56	37
RAMP3	Physical association	Medium	0.56	7
RASD1	Physical association	Medium	0.56	23
RBM22	Physical association	Medium	0.56	6
RBP3	Physical association	Medium	0.56	9
REM2	Physical association	Medium	0.56	2
RGL2	Physical association	Medium	0.56	6
RHNO1	Physical association	Medium	0.56	7
RNF38	Physical association	Medium	0.56	11
RPS19BP1	Physical association	Medium	0.56	8
RPUSD3	Physical association	Medium	0.56	4
SAPCD2	Physical association	Medium	0.56	11
SAXO1	Physical association	Medium	0.56	39
SCARF1	Physical association	Medium	0.56	18
SCNM1	Physical association	Medium	0.56	148
SEMA4C	Physical association	Medium	0.56	14
SH3KBP1	Physical association	Medium	0.56	33
SH3RF2	Physical association	Medium	0.56	9
SHISA6	Physical association	Medium	0.56	20
SLC12A4	Physical association	Medium	0.56	8
SLC13A5	Physical association	Medium	0.56	16
SLC25A18	Physical association	Medium	0.56	5
SLC43A2	Physical association	Medium	0.56	5
SLC5A5	Physical association	Medium	0.56	2
SLC6A20	Physical association	Medium	0.56	8
SLIT1	Physical association	Medium	0.56	8
SMARCC1	Physical association	Medium	0.56	31
SMARCD1	Physical association	Medium	0.56	104
SMARCE1	Physical association	Medium	0.56	56
SMCP	Physical association	Medium	0.56	67
SNRPC	Physical association	Medium	0.56	43
SNX18	Physical association	Medium	0.56	14
SOCS7	Physical association	Medium	0.56	12
SPATA46	Physical association	Medium	0.56	10
SPG7	Physical association	Medium	0.56	17
SPON1	Physical association	Medium	0.56	2
SPPL2C	Physical association	Medium	0.56	2
SPRY1	Physical association	Medium	0.56	59
SPTSSA	Physical association	Medium	0.56	5
SRD5A2	Physical association	Medium	0.56	2
STK16	Physical association	Medium	0.56	66
TAPBPL	Physical association	Medium	0.56	8
TBX2	Physical association	Medium	0.56	5
TBX6	Physical association	Medium	0.56	24
TCEA2	Physical association	Medium	0.56	88
TENT5B	Physical association	Medium	0.56	57
TEPSIN	Physical association	Medium	0.56	101
TEX37	Physical association	Medium	0.56	32
TEX45	Physical association	Medium	0.56	3
TFAP2D	Physical association	Medium	0.56	48
THAP7	Physical association	Medium	0.56	47
TIMM22	Physical association	Medium	0.56	3
TM7SF2	Physical association	Medium	0.56	2
TMEM174	Physical association	Medium	0.56	12
TNIP1	Physical association	Medium	0.56	67
TNIP3	Physical association	Medium	0.56	26
TNS4	Physical association	Medium	0.56	10
TRAPPC14	Physical association	Medium	0.56	6
TRIM42	Physical association	Medium	0.56	112
TSGA10IP	Physical association	Medium	0.56	83
TSPAN4	Physical association	Medium	0.56	30
TTPA	Physical association	Medium	0.56	36
TYK2	Physical association	Medium	0.56	13
UBXN7	Physical association	Medium	0.56	22
UNC5CL	Physical association	Medium	0.56	5
UTP23	Physical association	Medium	0.56	22
VASN	Physical association	Medium	0.56	42
VENTX	Physical association	Medium	0.56	60
VSTM4	Physical association	Medium	0.56	8
VWC2	Physical association	Medium	0.56	51
VWC2L	Physical association	Medium	0.56	20
WIF1	Physical association	Medium	0.56	4
WNT11	Physical association	Medium	0.56	17
YES1	Physical association	Medium	0.56	44
YY1	Physical association	Medium	0.56	47
ZBTB25	Physical association	Medium	0.56	24
ZBTB4	Physical association	Medium	0.56	9
ZCCHC14	Physical association	Medium	0.56	6
ZDHHC1	Physical association	Medium	0.56	14
ZIC1	Physical association	Medium	0.56	55
ZMYND10	Physical association	Medium	0.56	10
ZNF124	Physical association	Medium	0.56	45
ZNF165	Physical association	Medium	0.56	31
ZNF266	Physical association	Medium	0.56	8
ZNF319	Physical association	Medium	0.56	17
ZNF330	Physical association	Medium	0.56	43
ZNF408	Physical association	Medium	0.56	51
ZNF414	Physical association	Medium	0.56	42
ZNF417	Physical association	Medium	0.56	140
ZNF419	Physical association	Medium	0.56	3
ZNF438	Physical association	Medium	0.56	50
ZNF439	Physical association	Medium	0.56	19
ZNF440	Physical association	Medium	0.56	26
ZNF441	Physical association	Medium	0.56	7
ZNF497	Physical association	Medium	0.56	41
ZNF552	Physical association	Medium	0.56	27
ZNF575	Physical association	Medium	0.56	22
ZNF580	Physical association	Medium	0.56	15
ZNF581	Physical association	Medium	0.56	82
ZNF587	Physical association	Medium	0.56	102
ZNF648	Physical association	Medium	0.56	50
ZNF669	Physical association	Medium	0.56	15
ZNF683	Physical association	Medium	0.56	5
ZNF696	Physical association	Medium	0.56	30
ZNF764	Physical association	Medium	0.56	26
ZNF775	Physical association	Medium	0.56	9
ZNF835	Physical association	Medium	0.56	54
ZNF837	Physical association	Medium	0.56	68
ZNF843	Physical association	Medium	0.56	3
ZNHIT1	Physical association	Medium	0.56	22
ZSCAN5A	Physical association	Medium	0.56	3
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
CYSRT1 is not a metabolic protein