Protein interactions for LMO4 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	LMO4
Gene descriptionⁱ Full gene name according to HGNC.	LIM domain only 4
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Brain - Neuronal signaling (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enhanced (brain)
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.33
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Nucleoplasm In addition localized to the Midbody ring
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Brain - Neuronal signaling

Field

Cluster

Pathway

Number of interactions:

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
SMAD4	Physical association	High	0.83	27
LDB2	Physical association	High	0.8	21
GRHL2	Physical association	High	0.78	4
CCDC102B	Physical association	High	0.72	87
GABPB1	Physical association	High	0.72	16
GOLGA2	Physical association	High	0.72	349
KANK2	Physical association	High	0.72	151
KIAA1958	Physical association	High	0.72	11
KRT15	Physical association	High	0.72	100
KRT31	Physical association	High	0.72	284
TFIP11	Physical association	High	0.72	179
LDB1	Physical association	High	0.67	9
PDE4DIP	Physical association	High	0.67	31
ZNF202	Physical association	High	0.6	17
AARD	Physical association	Medium	0.56	13
ARNT2	Physical association	Medium	0.56	9
BANP	Physical association	Medium	0.56	58
BBS2	Physical association	Medium	0.56	19
BCAS2	Physical association	Medium	0.56	49
BIRC7	Physical association	Medium	0.56	25
C12orf40	Physical association	Medium	0.56	4
CALCOCO2	Physical association	Medium	0.56	117
CCDC120	Physical association	Medium	0.56	90
COG6	Physical association	Medium	0.56	49
CRNN	Physical association	Medium	0.56	1
CRYBB2	Physical association	Medium	0.56	5
CYSRT1	Physical association	Medium	0.56	396
DES	Physical association	Medium	0.56	36
ECM1	Physical association	Medium	0.56	27
ERCC6L	Physical association	Medium	0.56	3
EXOSC8	Physical association	Medium	0.56	46
FAM228A	Physical association	Medium	0.56	15
FHL3	Physical association	Medium	0.56	103
GOLGA6L9	Physical association	Medium	0.56	177
HGS	Physical association	Medium	0.56	177
HSF2BP	Physical association	Medium	0.56	223
ID3	Physical association	Medium	0.56	14
IKZF3	Physical association	Medium	0.56	130
KATNBL1	Physical association	Medium	0.56	31
KRT33B	Physical association	Medium	0.56	65
KRT34	Physical association	Medium	0.56	201
KRT38	Physical association	Medium	0.56	57
KRT39	Physical association	Medium	0.56	28
KRT40	Physical association	Medium	0.56	288
KRT74	Physical association	Medium	0.56	14
KRT75	Physical association	Medium	0.56	103
KRT76	Physical association	Medium	0.56	33
KRTAP11-1	Physical association	Medium	0.56	83
KRTAP3-1	Physical association	Medium	0.56	61
LZTS1	Physical association	Medium	0.56	73
MCCD1	Physical association	Medium	0.56	20
METTL27	Physical association	Medium	0.56	41
MYOD1	Physical association	Medium	0.56	6
MYOZ3	Physical association	Medium	0.56	44
N4BP3	Physical association	Medium	0.56	12
NFKBID	Physical association	Medium	0.56	83
NME4	Physical association	Medium	0.56	43
PELO	Physical association	Medium	0.56	20
PER2	Physical association	Medium	0.56	8
QRICH1	Physical association	Medium	0.56	36
RBAK	Physical association	Medium	0.56	20
RBPMS	Physical association	Medium	0.56	105
RCN1	Physical association	Medium	0.56	19
RNF8	Physical association	Medium	0.56	41
ROPN1	Physical association	Medium	0.56	37
RSPH6A	Physical association	Medium	0.56	2
SLC15A2	Physical association	Medium	0.56	20
STAT5B	Physical association	Medium	0.56	15
SUOX	Physical association	Medium	0.56	67
TCF4	Physical association	Medium	0.56	124
TEX14	Physical association	Medium	0.56	3
TLE5	Physical association	Medium	0.56	105
TRAF5	Physical association	Medium	0.56	35
TRIM27	Physical association	Medium	0.56	232
TRIM54	Physical association	Medium	0.56	151
UBQLN2	Physical association	Medium	0.56	212
VMAC	Physical association	Medium	0.56	12
VPS52	Physical association	Medium	0.56	83
ZBTB43	Physical association	Medium	0.56	21
ZMYND12	Physical association	Medium	0.56	66
ZNF135	Physical association	Medium	0.56	2
ZNF213	Physical association	Medium	0.56	7
ZNF397	Physical association	Medium	0.56	5
ZNF467	Physical association	Medium	0.56	3
ITSN1	Physical association	Medium	0.55	14
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
LMO4 is not a metabolic protein