Protein interactions for TRIM27 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TRIM27
Gene descriptionⁱ Full gene name according to HGNC.	Tripartite motif containing 27
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Cancer-related genes Disease related genes Enzymes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Mitochondrial translation (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.37
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Nucleoli In addition localized to the Nucleoplasm
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Non-specific - Mitochondrial translation

Field

Cluster

Pathway

Number of interactions:

232

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
ARHGEF3	Physical association	High	0.83	7
UBE2K	Physical association	High	0.81	60
PRPF31	Physical association	High	0.79	118
PSMB1	Physical association	High	0.79	83
ABCF3	Physical association	High	0.78	2
ATOSB	Physical association	High	0.78	50
BABAM1	Physical association	High	0.78	8
BAG1	Physical association	High	0.78	8
GPANK1	Physical association	High	0.78	65
POLE2	Physical association	High	0.78	11
PPP1R18	Physical association	High	0.78	68
PUS7L	Physical association	High	0.78	2
VPS25	Physical association	High	0.78	15
ZNF417	Physical association	High	0.78	140
EIF4E	Physical association	High	0.74	17
NIF3L1	Physical association	High	0.74	52
NDEL1	Physical association	High	0.74	60
ARHGEF5	Physical association	High	0.72	18
ARMC7	Physical association	High	0.72	58
ATPAF2	Physical association	High	0.72	57
BAG5	Physical association	High	0.72	13
BYSL	Physical association	High	0.72	119
CCDC102B	Physical association	High	0.72	87
CDKL3	Physical association	High	0.72	22
CPNE2	Physical association	High	0.72	13
CWF19L2	Physical association	High	0.72	65
DDX6	Physical association	High	0.72	66
DMRT3	Physical association	High	0.72	65
EHHADH	Physical association	High	0.72	94
EIF3D	Physical association	High	0.72	27
FBXW5	Physical association	High	0.72	21
GEM	Physical association	High	0.72	88
GFAP	Physical association	High	0.72	147
KAT14	Physical association	High	0.72	7
KCTD9	Physical association	High	0.72	77
LGALS14	Physical association	High	0.72	43
NCK2	Physical association	High	0.72	113
NEIL2	Physical association	High	0.72	8
NTAQ1	Physical association	High	0.72	302
NUDT21	Physical association	High	0.72	20
PIMREG	Physical association	High	0.72	18
POLR1C	Physical association	High	0.72	87
POLR3C	Physical association	High	0.72	29
PSMA1	Physical association	High	0.72	135
PSMB3	Physical association	High	0.72	15
SCNM1	Physical association	High	0.72	148
SNRPA	Physical association	High	0.72	36
SNRPB2	Physical association	High	0.72	16
STAMBPL1	Physical association	High	0.72	22
STK25	Physical association	High	0.72	10
TCEA2	Physical association	High	0.72	88
TEAD4	Physical association	High	0.72	30
USP2	Physical association	High	0.72	78
XPA	Physical association	High	0.72	17
ZNF581	Physical association	High	0.72	82
CLK2	Physical association	High	0.67	45
BMP7	Physical association	High	0.67	13
CDC23	Physical association	High	0.67	69
ERCC3	Physical association	High	0.67	14
GNPDA2	Physical association	High	0.67	2
GSE1	Physical association	High	0.67	15
ILK	Physical association	High	0.67	18
JOSD1	Physical association	High	0.67	24
KANSL1	Physical association	High	0.67	22
NEDD9	Physical association	High	0.67	12
OAS1	Physical association	High	0.67	4
SPATA2	Physical association	High	0.67	17
TBC1D22B	Physical association	High	0.67	46
TCHP	Physical association	High	0.67	40
TLE5	Physical association	High	0.67	105
TUFT1	Physical association	High	0.67	5
ZGPAT	Physical association	High	0.67	25
NOD2	Direct interaction	High	0.66	11
ZBTB16	Physical association	High	0.62	43
EIF3E	Physical association	High	0.6	26
PIK3C2B	Physical association	High	0.6	5
KRT1	Physical association	High	0.6	32
ACSF3	Physical association	Medium	0.56	4
AEN	Physical association	Medium	0.56	27
AMMECR1	Physical association	Medium	0.56	7
AP1M1	Physical association	Medium	0.56	67
ARID5A	Physical association	Medium	0.56	94
ARPIN	Physical association	Medium	0.56	3
ATOSA	Physical association	Medium	0.56	5
AXIN1	Physical association	Medium	0.56	40
BAG3	Physical association	Medium	0.56	58
BEX2	Physical association	Medium	0.56	67
CAPN7	Physical association	Medium	0.56	12
CARD10	Physical association	Medium	0.56	83
CATSPER1	Physical association	Medium	0.56	95
CBX8	Physical association	Medium	0.56	78
CCDC185	Physical association	Medium	0.56	34
CCDC198	Physical association	Medium	0.56	16
CCDC87	Physical association	Medium	0.56	7
CCDC92	Physical association	Medium	0.56	7
CDC20B	Physical association	Medium	0.56	11
CDC7	Physical association	Medium	0.56	21
CDK18	Physical association	Medium	0.56	45
CFAP206	Physical association	Medium	0.56	46
CHCHD3	Physical association	Medium	0.56	37
CKS1B	Physical association	Medium	0.56	43
CNNM3	Physical association	Medium	0.56	59
COX5B	Physical association	Medium	0.56	29
CSRP2	Physical association	Medium	0.56	4
DCX	Physical association	Medium	0.56	13
DTNBP1	Physical association	Medium	0.56	22
EIF4A3	Physical association	Medium	0.56	30
EIF4E2	Physical association	Medium	0.56	32
ENKD1	Physical association	Medium	0.56	159
EXOC8	Physical association	Medium	0.56	67
FAM110A	Physical association	Medium	0.56	41
FAM161A	Physical association	Medium	0.56	118
FAM83A	Physical association	Medium	0.56	22
FAM90A1	Physical association	Medium	0.56	128
FANCM	Physical association	Medium	0.56	4
FARS2	Physical association	Medium	0.56	56
FASTKD5	Physical association	Medium	0.56	3
FNDC11	Physical association	Medium	0.56	37
FOXB1	Physical association	Medium	0.56	5
FOXC2	Physical association	Medium	0.56	7
GADD45GIP1	Physical association	Medium	0.56	55
GAS2L2	Physical association	Medium	0.56	29
GATAD2B	Physical association	Medium	0.56	19
GFM2	Physical association	Medium	0.56	4
GLYCTK	Physical association	Medium	0.56	48
GPKOW	Physical association	Medium	0.56	40
GRB14	Physical association	Medium	0.56	3
GRB2	Physical association	Medium	0.56	165
HAPLN2	Physical association	Medium	0.56	36
HAUS1	Physical association	Medium	0.56	83
HGS	Physical association	Medium	0.56	177
HOXB5	Physical association	Medium	0.56	47
HOXB9	Physical association	Medium	0.56	42
HOXC8	Physical association	Medium	0.56	74
HYCC1	Physical association	Medium	0.56	4
HYCC2	Physical association	Medium	0.56	4
ILF2	Physical association	Medium	0.56	7
INO80B	Physical association	Medium	0.56	49
INPP5J	Physical association	Medium	0.56	15
IP6K3	Physical association	Medium	0.56	13
IQCN	Physical association	Medium	0.56	6
IQUB	Physical association	Medium	0.56	56
KAT5	Physical association	Medium	0.56	180
KIFC3	Physical association	Medium	0.56	70
KRT3	Physical association	Medium	0.56	33
KRT75	Physical association	Medium	0.56	103
KRT76	Physical association	Medium	0.56	33
LAGE3	Physical association	Medium	0.56	19
LASP1	Physical association	Medium	0.56	21
LENG1	Physical association	Medium	0.56	63
LINGO1	Physical association	Medium	0.56	11
LMNB2	Physical association	Medium	0.56	22
LMO1	Physical association	Medium	0.56	88
LMO4	Physical association	Medium	0.56	85
LNX1	Physical association	Medium	0.56	333
LONRF1	Physical association	Medium	0.56	77
MAD2L2	Physical association	Medium	0.56	32
MAGOHB	Physical association	Medium	0.56	56
MAPKBP1	Physical association	Medium	0.56	48
MAT2B	Physical association	Medium	0.56	7
MCM7	Physical association	Medium	0.56	25
MEMO1	Physical association	Medium	0.56	16
MOS	Physical association	Medium	0.56	46
MRPL40	Physical association	Medium	0.56	7
MSRB1	Physical association	Medium	0.56	4
MTMR6	Physical association	Medium	0.56	4
NCOA1	Physical association	Medium	0.56	14
NEBL	Physical association	Medium	0.56	28
NEK6	Physical association	Medium	0.56	20
NELFE	Physical association	Medium	0.56	5
NME7	Physical association	Medium	0.56	62
NOTCH2NLA	Physical association	Medium	0.56	190
P2RX7	Physical association	Medium	0.56	10
PIN1	Physical association	Medium	0.56	112
PKN1	Physical association	Medium	0.56	59
PLEKHN1	Physical association	Medium	0.56	9
PPL	Physical association	Medium	0.56	31
PRAM1	Physical association	Medium	0.56	17
PRKAA1	Physical association	Medium	0.56	33
PRPF18	Physical association	Medium	0.56	63
PRR35	Physical association	Medium	0.56	57
PTPMT1	Physical association	Medium	0.56	25
PTPN23	Physical association	Medium	0.56	13
QARS1	Physical association	Medium	0.56	53
RAB29	Physical association	Medium	0.56	4
RAMAC	Physical association	Medium	0.56	37
RBM23	Physical association	Medium	0.56	6
RBM41	Physical association	Medium	0.56	23
RCOR3	Physical association	Medium	0.56	24
RHPN1	Physical association	Medium	0.56	15
RIBC1	Physical association	Medium	0.56	21
RIN1	Physical association	Medium	0.56	38
RSPH14	Physical association	Medium	0.56	36
SDCBP	Physical association	Medium	0.56	240
SH2D4A	Physical association	Medium	0.56	63
SIAH1	Physical association	Medium	0.56	88
SMARCD1	Physical association	Medium	0.56	104
SMG9	Physical association	Medium	0.56	32
SORBS3	Physical association	Medium	0.56	87
SPATC1L	Physical association	Medium	0.56	9
STK16	Physical association	Medium	0.56	66
SYNGAP1	Physical association	Medium	0.56	10
SYT17	Physical association	Medium	0.56	34
TACO1	Physical association	Medium	0.56	15
THOC1	Physical association	Medium	0.56	15
TNS4	Physical association	Medium	0.56	10
TPRKB	Physical association	Medium	0.56	3
TRAF4	Physical association	Medium	0.56	73
TRIM42	Physical association	Medium	0.56	112
TRIM50	Physical association	Medium	0.56	31
TSGA10IP	Physical association	Medium	0.56	83
TSHZ3	Physical association	Medium	0.56	24
TTLL10	Physical association	Medium	0.56	10
TXNDC9	Physical association	Medium	0.56	18
USE1	Physical association	Medium	0.56	17
UTP14C	Physical association	Medium	0.56	17
UTP23	Physical association	Medium	0.56	22
VEZF1	Physical association	Medium	0.56	40
VPS28	Physical association	Medium	0.56	12
VPS9D1	Physical association	Medium	0.56	21
YJU2	Physical association	Medium	0.56	15
ZC2HC1C	Physical association	Medium	0.56	18
ZFYVE21	Physical association	Medium	0.56	22
ZMYND19	Physical association	Medium	0.56	39
ZNF414	Physical association	Medium	0.56	42
ZNF572	Physical association	Medium	0.56	58
ZNF580	Physical association	Medium	0.56	15
ZNF587	Physical association	Medium	0.56	102
ZNF79	Physical association	Medium	0.56	6
MRRF	Physical association	Medium	0.55	6
TRIM29	Physical association	Medium	0.55	13
TUBGCP4	Physical association	Medium	0.49	11
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
TRIM27 is not a metabolic protein