Protein interactions for GFAP - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GFAP
Gene descriptionⁱ Full gene name according to HGNC.	Glial fibrillary acidic protein
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Candidate cardiovascular disease genes Disease related genes Human disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	17

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Oligodendrocytes - Myelination (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enriched (brain)
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.85
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Intermediate filaments
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Oligodendrocytes - Myelination

Field

Cluster

Pathway

Number of interactions:

147

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
GOLGA2	Physical association	High	0.81	349
KRT15	Physical association	High	0.81	100
KRT19	Physical association	High	0.81	65
NEFL	Physical association	High	0.81	70
LGALS14	Physical association	High	0.78	43
NXF1	Physical association	High	0.78	62
VIM	Physical association	High	0.78	86
KIAA0408	Physical association	High	0.74	24
CWF19L2	Physical association	High	0.72	65
DES	Physical association	High	0.72	36
KRT13	Physical association	High	0.72	20
MYBPHL	Physical association	High	0.72	10
TRIM27	Physical association	High	0.72	232
ZNF774	Physical association	High	0.72	68
PDLIM1	Physical association	High	0.67	2
HTT	Physical association	High	0.67	665
PDZK1	Physical association	High	0.67	6
PIH1D2	Physical association	High	0.67	64
SH3YL1	Physical association	High	0.67	4
SMARCB1	Physical association	High	0.67	33
ALDH1A1	Physical association	Medium	0.56	4
ATP6V1B2	Physical association	Medium	0.56	7
BAHD1	Physical association	Medium	0.56	54
BCAS2	Physical association	Medium	0.56	49
BIRC2	Physical association	Medium	0.56	30
BRK1	Physical association	Medium	0.56	46
C6orf141	Physical association	Medium	0.56	8
CARD10	Physical association	Medium	0.56	83
CCDC120	Physical association	Medium	0.56	90
CCNC	Physical association	Medium	0.56	69
CDC23	Physical association	Medium	0.56	69
CDC37	Physical association	Medium	0.56	124
CFAP206	Physical association	Medium	0.56	46
CRLF3	Physical association	Medium	0.56	24
CT55	Physical association	Medium	0.56	22
CTNNB1	Physical association	Medium	0.56	81
DBF4	Physical association	Medium	0.56	5
DDIT3	Physical association	Medium	0.56	30
ENKD1	Physical association	Medium	0.56	159
EPM2AIP1	Physical association	Medium	0.56	40
ESS2	Physical association	Medium	0.56	10
EXTL2	Physical association	Medium	0.56	3
FAM50B	Physical association	Medium	0.56	39
FANCG	Physical association	Medium	0.56	35
FASTKD1	Physical association	Medium	0.56	9
H3C13	Physical association	Medium	0.56	27
H3C14	Physical association	Medium	0.56	27
H3C15	Physical association	Medium	0.56	27
HNRNPK	Physical association	Medium	0.56	49
HYAL2	Physical association	Medium	0.56	12
IQUB	Physical association	Medium	0.56	56
JADE3	Physical association	Medium	0.56	7
JPH3	Physical association	Medium	0.56	146
KLHL20	Physical association	Medium	0.56	31
KRT27	Physical association	Medium	0.56	113
KRT31	Physical association	Medium	0.56	284
KRT33B	Physical association	Medium	0.56	65
KRT39	Physical association	Medium	0.56	28
LENG1	Physical association	Medium	0.56	63
LENG8	Physical association	Medium	0.56	35
LGALS9C	Physical association	Medium	0.56	23
LMO2	Physical association	Medium	0.56	61
LNX1	Physical association	Medium	0.56	333
LONRF2	Physical association	Medium	0.56	12
LPIN1	Physical association	Medium	0.56	18
MAPK9	Physical association	Medium	0.56	48
MCRS1	Physical association	Medium	0.56	97
METTL27	Physical association	Medium	0.56	41
MICAL2	Physical association	Medium	0.56	8
MLC1	Physical association	Medium	0.56	13
MOS	Physical association	Medium	0.56	46
MSRB2	Physical association	Medium	0.56	9
MYL11	Physical association	Medium	0.56	5
NAP1L3	Physical association	Medium	0.56	5
NEBL	Physical association	Medium	0.56	28
NFKBID	Physical association	Medium	0.56	83
NFX1	Physical association	Medium	0.56	5
NOD1	Physical association	Medium	0.56	11
NTAQ1	Physical association	Medium	0.56	302
NUDT21	Physical association	Medium	0.56	20
ODF3L2	Physical association	Medium	0.56	10
OTUB1	Physical association	Medium	0.56	43
PCSK7	Physical association	Medium	0.56	9
PDLIM5	Physical association	Medium	0.56	9
PECAM1	Physical association	Medium	0.56	58
PER1	Physical association	Medium	0.56	21
PERP	Physical association	Medium	0.56	7
PHF19	Physical association	Medium	0.56	24
PIAS2	Physical association	Medium	0.56	16
PKP3	Physical association	Medium	0.56	3
PNMA5	Physical association	Medium	0.56	53
PNP	Physical association	Medium	0.56	9
PPP1R16A	Physical association	Medium	0.56	35
PPP1R16B	Physical association	Medium	0.56	31
PPP1R18	Physical association	Medium	0.56	68
RAB38	Physical association	Medium	0.56	9
RAB5A	Physical association	Medium	0.56	19
RASSF2	Physical association	Medium	0.56	15
RHPN1	Physical association	Medium	0.56	15
RORA	Physical association	Medium	0.56	3
RUFY4	Physical association	Medium	0.56	9
RYBP	Physical association	Medium	0.56	44
SAXO1	Physical association	Medium	0.56	39
SKIC8	Physical association	Medium	0.56	30
SLU7	Physical association	Medium	0.56	22
SMARCD1	Physical association	Medium	0.56	104
SNRNP40	Physical association	Medium	0.56	9
SNW1	Physical association	Medium	0.56	89
SPATA2	Physical association	Medium	0.56	17
SPATA22	Physical association	Medium	0.56	16
SPATA2L	Physical association	Medium	0.56	16
SPRED1	Physical association	Medium	0.56	308
SPRED2	Physical association	Medium	0.56	38
STK36	Physical association	Medium	0.56	7
SYNC	Physical association	Medium	0.56	9
TASOR2	Physical association	Medium	0.56	34
TBC1D21	Physical association	Medium	0.56	16
TBC1D22B	Physical association	Medium	0.56	46
TCAP	Physical association	Medium	0.56	34
TFIP11	Physical association	Medium	0.56	179
THAP1	Physical association	Medium	0.56	81
TLE5	Physical association	Medium	0.56	105
TMEM186	Physical association	Medium	0.56	4
TNFAIP1	Physical association	Medium	0.56	31
TSNAX	Physical association	Medium	0.56	36
TXN	Physical association	Medium	0.56	26
UBXN8	Physical association	Medium	0.56	7
USP10	Physical association	Medium	0.56	8
VSX2	Physical association	Medium	0.56	20
WDR83	Physical association	Medium	0.56	30
WFS1	Physical association	Medium	0.56	315
YES1	Physical association	Medium	0.56	44
ZC2HC1C	Physical association	Medium	0.56	18
ZFPM2	Physical association	Medium	0.56	4
ZKSCAN3	Physical association	Medium	0.56	12
ZKSCAN5	Physical association	Medium	0.56	5
ZNF19	Physical association	Medium	0.56	23
ZNF20	Physical association	Medium	0.56	43
ZNF232	Physical association	Medium	0.56	21
ZNF436	Physical association	Medium	0.56	19
ZNF500	Physical association	Medium	0.56	8
ZNF572	Physical association	Medium	0.56	58
ZNF581	Physical association	Medium	0.56	82
ZNF655	Physical association	Medium	0.56	117
ZSCAN22	Physical association	Medium	0.56	27
ZSCAN9	Physical association	Medium	0.56	21
RIBC2	Physical association	Medium	0.55	2
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
GFAP is not a metabolic protein