Protein interactions for WFS1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	WFS1
Gene descriptionⁱ Full gene name according to HGNC.	Wolframin ER transmembrane glycoprotein
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes Plasma proteins Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	12

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Neuronal - Transcription (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.31
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Not available
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Neuronal - Transcription

Field

Cluster

Pathway

Number of interactions:

315

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
IL18RAP	Physical association	High	0.61	1
ATP1B1	Physical association	Medium	0.58	7
ABCG4	Physical association	Medium	0.56	5
AGA	Physical association	Medium	0.56	3
AK3	Physical association	Medium	0.56	8
AKR1A1	Physical association	Medium	0.56	3
ANAPC13	Physical association	Medium	0.56	4
ANP32B	Physical association	Medium	0.56	10
ANXA5	Physical association	Medium	0.56	5
ANXA8	Physical association	Medium	0.56	14
APP	Physical association	Medium	0.56	312
AQP6	Physical association	Medium	0.56	264
AQP8	Physical association	Medium	0.56	11
ARFGAP3	Physical association	Medium	0.56	29
ASCL4	Physical association	Medium	0.56	34
ATP6V1B1	Physical association	Medium	0.56	8
ATP6V1B2	Physical association	Medium	0.56	7
BAG3	Physical association	Medium	0.56	58
BATF	Physical association	Medium	0.56	18
BCL2L13	Physical association	Medium	0.56	42
BECN1	Physical association	Medium	0.56	48
BMF	Physical association	Medium	0.56	21
BRME1	Physical association	Medium	0.56	19
BSND	Physical association	Medium	0.56	25
BTRC	Physical association	Medium	0.56	37
C14orf39	Physical association	Medium	0.56	3
C17orf49	Physical association	Medium	0.56	6
C1D	Physical association	Medium	0.56	11
C1orf216	Physical association	Medium	0.56	69
C2orf49	Physical association	Medium	0.56	2
C7orf50	Physical association	Medium	0.56	4
C8orf48	Physical association	Medium	0.56	17
CAMK1G	Physical association	Medium	0.56	4
CCAR2	Physical association	Medium	0.56	6
CCDC141	Physical association	Medium	0.56	7
CCDC9	Physical association	Medium	0.56	4
CCNE2	Physical association	Medium	0.56	6
CCT2	Physical association	Medium	0.56	11
CD79A	Physical association	Medium	0.56	144
CDCA7	Physical association	Medium	0.56	2
CDKAL1	Physical association	Medium	0.56	3
CHCHD3	Physical association	Medium	0.56	37
CIAO2B	Physical association	Medium	0.56	19
CITED2	Physical association	Medium	0.56	6
CKMT1A	Physical association	Medium	0.56	10
CKMT1B	Physical association	Medium	0.56	10
CLEC11A	Physical association	Medium	0.56	6
CLINT1	Physical association	Medium	0.56	6
CLIP3	Physical association	Medium	0.56	5
CLPP	Physical association	Medium	0.56	19
CMSS1	Physical association	Medium	0.56	1
CNPY3	Physical association	Medium	0.56	9
COMT	Physical association	Medium	0.56	53
COPS2	Physical association	Medium	0.56	13
CRIPT	Physical association	Medium	0.56	2
CSTA	Physical association	Medium	0.56	5
CXorf38	Physical association	Medium	0.56	10
CYB5A	Physical association	Medium	0.56	3
CYFIP1	Physical association	Medium	0.56	10
DCLRE1B	Physical association	Medium	0.56	8
DDX39A	Physical association	Medium	0.56	9
DENND2B	Physical association	Medium	0.56	2
DISP1	Physical association	Medium	0.56	2
DMRTA1	Physical association	Medium	0.56	2
DNAJC4	Physical association	Medium	0.56	3
DNASE1L1	Physical association	Medium	0.56	10
DNMT3A	Physical association	Medium	0.56	14
DPYSL4	Physical association	Medium	0.56	6
DPYSL5	Physical association	Medium	0.56	16
DUSP16	Physical association	Medium	0.56	3
DVL3	Physical association	Medium	0.56	120
DYNLT1	Physical association	Medium	0.56	36
ECRG4	Physical association	Medium	0.56	2
EDRF1	Physical association	Medium	0.56	6
EIF3F	Physical association	Medium	0.56	42
EIF5B	Physical association	Medium	0.56	4
EPS8L2	Physical association	Medium	0.56	5
ERCC6L	Physical association	Medium	0.56	3
ESM1	Physical association	Medium	0.56	7
ESR1	Physical association	Medium	0.56	57
ESRP1	Physical association	Medium	0.56	28
EXOC5	Physical association	Medium	0.56	46
EYA3	Physical association	Medium	0.56	8
FABP7	Physical association	Medium	0.56	5
FAM111B	Physical association	Medium	0.56	4
FAM117B	Physical association	Medium	0.56	21
FAM163A	Physical association	Medium	0.56	17
FAM209A	Physical association	Medium	0.56	199
FAM98C	Physical association	Medium	0.56	9
FAM9A	Physical association	Medium	0.56	47
FANCG	Physical association	Medium	0.56	35
FANK1	Physical association	Medium	0.56	5
FASTKD1	Physical association	Medium	0.56	9
FBH1	Physical association	Medium	0.56	3
FBLN5	Physical association	Medium	0.56	11
FBXO4	Physical association	Medium	0.56	6
FBXO42	Physical association	Medium	0.56	5
FEZ2	Physical association	Medium	0.56	12
FOSL1	Physical association	Medium	0.56	17
FTL	Physical association	Medium	0.56	13
G2E3	Physical association	Medium	0.56	6
G6PC1	Physical association	Medium	0.56	2
GALNT6	Physical association	Medium	0.56	2
GFAP	Physical association	Medium	0.56	147
GFOD1	Physical association	Medium	0.56	17
GLI4	Physical association	Medium	0.56	3
GPANK1	Physical association	Medium	0.56	65
GPR141	Physical association	Medium	0.56	8
GPR89B	Physical association	Medium	0.56	1
GPSM3	Physical association	Medium	0.56	38
H2AP	Physical association	Medium	0.56	15
H3-5	Physical association	Medium	0.56	17
H3C1	Physical association	Medium	0.56	52
H3C10	Physical association	Medium	0.56	52
H3C11	Physical association	Medium	0.56	52
H3C12	Physical association	Medium	0.56	52
H3C2	Physical association	Medium	0.56	52
H3C3	Physical association	Medium	0.56	52
H3C4	Physical association	Medium	0.56	52
H3C6	Physical association	Medium	0.56	52
H3C7	Physical association	Medium	0.56	52
H3C8	Physical association	Medium	0.56	52
HHEX	Physical association	Medium	0.56	23
HK3	Physical association	Medium	0.56	6
HNRNPDL	Physical association	Medium	0.56	3
IGFBP4	Physical association	Medium	0.56	10
IL4I1	Physical association	Medium	0.56	2
ING4	Physical association	Medium	0.56	11
IQCF2	Physical association	Medium	0.56	5
IQUB	Physical association	Medium	0.56	56
ISCA2	Physical association	Medium	0.56	13
JMJD7	Physical association	Medium	0.56	14
KCNMB2	Physical association	Medium	0.56	2
KCTD13	Physical association	Medium	0.56	22
KDSR	Physical association	Medium	0.56	3
KEAP1	Physical association	Medium	0.56	53
KIAA0408	Physical association	Medium	0.56	24
KIF1A	Physical association	Medium	0.56	5
KLF15	Physical association	Medium	0.56	30
KLF3	Physical association	Medium	0.56	28
KLHL20	Physical association	Medium	0.56	31
KRT19	Physical association	Medium	0.56	65
KRT222	Physical association	Medium	0.56	9
KRT33B	Physical association	Medium	0.56	65
KRTAP13-3	Physical association	Medium	0.56	58
KRTAP19-7	Physical association	Medium	0.56	71
KRTAP8-1	Physical association	Medium	0.56	76
LCA5L	Physical association	Medium	0.56	14
LCAT	Physical association	Medium	0.56	2
LCE1B	Physical association	Medium	0.56	69
LCE2A	Physical association	Medium	0.56	43
LENG8	Physical association	Medium	0.56	35
LGALS8	Physical association	Medium	0.56	6
LHX6	Physical association	Medium	0.56	18
LHX8	Physical association	Medium	0.56	28
LNX2	Physical association	Medium	0.56	63
LOXL4	Physical association	Medium	0.56	15
LPIN1	Physical association	Medium	0.56	18
MAF1	Physical association	Medium	0.56	4
MAGEB18	Physical association	Medium	0.56	10
MAP2K6	Physical association	Medium	0.56	7
MECP2	Physical association	Medium	0.56	33
METTL27	Physical association	Medium	0.56	41
MIS18A	Physical association	Medium	0.56	26
MLC1	Physical association	Medium	0.56	13
MPND	Physical association	Medium	0.56	15
MRFAP1	Physical association	Medium	0.56	34
MRFAP1L1	Physical association	Medium	0.56	46
MRPS17	Physical association	Medium	0.56	3
MSL3	Physical association	Medium	0.56	1
MYL11	Physical association	Medium	0.56	5
MYLK2	Physical association	Medium	0.56	4
NAALAD2	Physical association	Medium	0.56	3
NCLN	Physical association	Medium	0.56	2
NDN	Physical association	Medium	0.56	11
NDUFAF4	Physical association	Medium	0.56	4
NGEF	Physical association	Medium	0.56	8
NR1D2	Physical association	Medium	0.56	10
NUDT4	Physical association	Medium	0.56	4
NUFIP2	Physical association	Medium	0.56	58
OIP5	Physical association	Medium	0.56	113
OTUB1	Physical association	Medium	0.56	43
P2RY6	Physical association	Medium	0.56	15
PABPC3	Physical association	Medium	0.56	3
PAK5	Physical association	Medium	0.56	30
PALMD	Physical association	Medium	0.56	2
PALS1	Physical association	Medium	0.56	19
PELO	Physical association	Medium	0.56	20
PER1	Physical association	Medium	0.56	21
PERP	Physical association	Medium	0.56	7
PGLYRP3	Physical association	Medium	0.56	11
PHF5A	Physical association	Medium	0.56	4
PIAS1	Physical association	Medium	0.56	38
PLA2G12A	Physical association	Medium	0.56	2
PLEKHG7	Physical association	Medium	0.56	18
PLIN2	Physical association	Medium	0.56	5
PLPPR1	Physical association	Medium	0.56	13
POLB	Physical association	Medium	0.56	4
POLR3F	Physical association	Medium	0.56	12
PPTC7	Physical association	Medium	0.56	6
PRKAA2	Physical association	Medium	0.56	78
PRPS1	Physical association	Medium	0.56	79
PRPS2	Physical association	Medium	0.56	10
PRUNE2	Physical association	Medium	0.56	13
PSMB1	Physical association	Medium	0.56	83
PSMC6	Physical association	Medium	0.56	44
PSMD5	Physical association	Medium	0.56	9
PUM1	Physical association	Medium	0.56	3
QARS1	Physical association	Medium	0.56	53
RAB11B	Physical association	Medium	0.56	9
RAI2	Physical association	Medium	0.56	13
RBM14	Physical association	Medium	0.56	11
RBM17	Physical association	Medium	0.56	21
RHPN1	Physical association	Medium	0.56	15
RMND5A	Physical association	Medium	0.56	18
RNF10	Physical association	Medium	0.56	13
RNF168	Physical association	Medium	0.56	5
RNF183	Physical association	Medium	0.56	30
RNF208	Physical association	Medium	0.56	20
RNH1	Physical association	Medium	0.56	4
RPL3	Physical association	Medium	0.56	3
RPS15A	Physical association	Medium	0.56	8
RPS27A	Physical association	Medium	0.56	15
RPSA	Physical association	Medium	0.56	11
RUSF1	Physical association	Medium	0.56	49
RXYLT1	Physical association	Medium	0.56	4
S100P	Physical association	Medium	0.56	15
SAMD7	Physical association	Medium	0.56	5
SARNP	Physical association	Medium	0.56	5
SCAMP4	Physical association	Medium	0.56	16
SDC2	Physical association	Medium	0.56	7
SDCBP	Physical association	Medium	0.56	240
SELE	Physical association	Medium	0.56	3
SEMA4C	Physical association	Medium	0.56	14
SENP3	Physical association	Medium	0.56	8
SEPTIN6	Physical association	Medium	0.56	17
SERINC3	Physical association	Medium	0.56	3
SH3KBP1	Physical association	Medium	0.56	33
SHLD1	Physical association	Medium	0.56	6
SKIL	Physical association	Medium	0.56	17
SLC13A2	Physical association	Medium	0.56	3
SLC16A6	Physical association	Medium	0.56	1
SLITRK3	Physical association	Medium	0.56	1
SMU1	Physical association	Medium	0.56	10
SNAPC3	Physical association	Medium	0.56	10
SPINK2	Physical association	Medium	0.56	6
SPPL2A	Physical association	Medium	0.56	2
SPRED2	Physical association	Medium	0.56	38
SPRY4	Physical association	Medium	0.56	30
SRARP	Physical association	Medium	0.56	2
STAM2	Physical association	Medium	0.56	31
STOML2	Physical association	Medium	0.56	3
STT3A	Physical association	Medium	0.56	7
STUB1	Physical association	Medium	0.56	54
SUMF2	Physical association	Medium	0.56	8
SYCE3	Physical association	Medium	0.56	10
SYNC	Physical association	Medium	0.56	9
SYT3	Physical association	Medium	0.56	7
TBPL1	Physical association	Medium	0.56	7
TCEAL4	Physical association	Medium	0.56	4
TCEAL8	Physical association	Medium	0.56	8
TCF25	Physical association	Medium	0.56	9
TCP10L	Physical association	Medium	0.56	28
TDG	Physical association	Medium	0.56	13
TENT5B	Physical association	Medium	0.56	57
TEX19	Physical association	Medium	0.56	6
THUMPD2	Physical association	Medium	0.56	2
TIMM17B	Physical association	Medium	0.56	18
TIMM8A	Physical association	Medium	0.56	13
TLR10	Physical association	Medium	0.56	4
TMEM61	Physical association	Medium	0.56	11
TNNI3	Physical association	Medium	0.56	6
TRIM23	Physical association	Medium	0.56	142
TRMT61B	Physical association	Medium	0.56	4
TSC22D4	Physical association	Medium	0.56	30
TTC1	Physical association	Medium	0.56	7
TUBB6	Physical association	Medium	0.56	4
UBAC1	Physical association	Medium	0.56	24
UBE2E3	Physical association	Medium	0.56	24
UBE2J2	Physical association	Medium	0.56	7
UBE2K	Physical association	Medium	0.56	60
VDAC2	Physical association	Medium	0.56	19
VPS37A	Physical association	Medium	0.56	18
VSX2	Physical association	Medium	0.56	20
WDR77	Physical association	Medium	0.56	6
WDR83	Physical association	Medium	0.56	30
WWP2	Physical association	Medium	0.56	51
XRCC6	Physical association	Medium	0.56	21
YIF1A	Physical association	Medium	0.56	66
YY1	Physical association	Medium	0.56	47
ZCRB1	Physical association	Medium	0.56	3
ZDHHC17	Physical association	Medium	0.56	30
ZFP64	Physical association	Medium	0.56	14
ZKSCAN8	Physical association	Medium	0.56	14
ZNF124	Physical association	Medium	0.56	45
ZNF138	Physical association	Medium	0.56	16
ZNF225	Physical association	Medium	0.56	1
ZNF239	Physical association	Medium	0.56	7
ZNF366	Physical association	Medium	0.56	22
ZNF436	Physical association	Medium	0.56	19
ZNF440	Physical association	Medium	0.56	26
ZNF497	Physical association	Medium	0.56	41
ZNF524	Physical association	Medium	0.56	22
ZNF57	Physical association	Medium	0.56	14
ZNF572	Physical association	Medium	0.56	58
ZNF670	Physical association	Medium	0.56	19
ZNF696	Physical association	Medium	0.56	30
ZNF697	Physical association	Medium	0.56	4
ZNF774	Physical association	Medium	0.56	68
ZNF791	Physical association	Medium	0.56	2
ZSCAN26	Physical association	Medium	0.56	15
ZSCAN9	Physical association	Medium	0.56	21
ZXDC	Physical association	Medium	0.56	19
ATP2A2	Physical association	Medium	0.52	4
TERF1	Physical association	Medium	0.51	71
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
WFS1 is not a metabolic protein