Protein interactions for FAM209A - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FAM209A
Gene descriptionⁱ Full gene name according to HGNC.	Family with sequence similarity 209 member A
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Testis - Spermatogenesis (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enriched (testis)
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.90
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Plasma membrane, Cell Junctions
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Testis - Spermatogenesis

Field

Cluster

Pathway

Number of interactions:

199

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
ADGRE2	Physical association	Medium	0.56	18
ADIPOQ	Physical association	Medium	0.56	46
ALG8	Physical association	Medium	0.56	8
APMAP	Physical association	Medium	0.56	1
APOC3	Physical association	Medium	0.56	3
APOD	Physical association	Medium	0.56	38
APOL2	Physical association	Medium	0.56	26
AQP1	Physical association	Medium	0.56	106
AQP2	Physical association	Medium	0.56	33
AQP3	Physical association	Medium	0.56	23
ARV1	Physical association	Medium	0.56	11
ASGR1	Physical association	Medium	0.56	27
B4GALNT2	Physical association	Medium	0.56	2
BET1	Physical association	Medium	0.56	41
BIK	Physical association	Medium	0.56	79
BMP10	Physical association	Medium	0.56	51
BNIP2	Physical association	Medium	0.56	37
BNIP3	Physical association	Medium	0.56	49
BTN2A2	Physical association	Medium	0.56	33
C11orf24	Physical association	Medium	0.56	7
C14orf180	Physical association	Medium	0.56	38
C2	Physical association	Medium	0.56	6
C3orf52	Physical association	Medium	0.56	57
CANT1	Physical association	Medium	0.56	2
CCL4L2	Physical association	Medium	0.56	31
CD53	Physical association	Medium	0.56	57
CD59	Physical association	Medium	0.56	3
CD81	Physical association	Medium	0.56	22
CDIPT	Physical association	Medium	0.56	47
CDS1	Physical association	Medium	0.56	5
CDS2	Physical association	Medium	0.56	29
CLDN2	Physical association	Medium	0.56	16
CLDN4	Physical association	Medium	0.56	14
CLDND2	Physical association	Medium	0.56	24
CLEC4G	Physical association	Medium	0.56	9
CLN6	Physical association	Medium	0.56	21
CMTM7	Physical association	Medium	0.56	39
CNIH1	Physical association	Medium	0.56	21
CNPY3	Physical association	Medium	0.56	9
COMT	Physical association	Medium	0.56	53
CTRL	Physical association	Medium	0.56	3
CTXN3	Physical association	Medium	0.56	51
CYB561D2	Physical association	Medium	0.56	16
CYB5B	Physical association	Medium	0.56	37
CYBC1	Physical association	Medium	0.56	51
DEFB121	Physical association	Medium	0.56	8
DEFB128	Physical association	Medium	0.56	1
DNAJC30	Physical association	Medium	0.56	23
DOLK	Physical association	Medium	0.56	19
EBP	Physical association	Medium	0.56	159
EMC6	Physical association	Medium	0.56	16
EMD	Physical association	Medium	0.56	72
ERG28	Physical association	Medium	0.56	48
ERMP1	Physical association	Medium	0.56	29
FA2H	Physical association	Medium	0.56	25
FAM20B	Physical association	Medium	0.56	8
FAM3C	Physical association	Medium	0.56	45
FATE1	Physical association	Medium	0.56	78
FDFT1	Physical association	Medium	0.56	12
FIS1	Physical association	Medium	0.56	22
GAST	Physical association	Medium	0.56	18
GET3	Physical association	Medium	0.56	32
GHITM	Physical association	Medium	0.56	7
GIMAP1	Physical association	Medium	0.56	40
GJB2	Physical association	Medium	0.56	33
GKN1	Physical association	Medium	0.56	13
GKN2	Physical association	Medium	0.56	1
GOSR2	Physical association	Medium	0.56	45
GPR108	Physical association	Medium	0.56	6
GPR151	Physical association	Medium	0.56	35
GPR37L1	Physical association	Medium	0.56	49
GYPA	Physical association	Medium	0.56	24
HACD2	Physical association	Medium	0.56	8
HHATL	Physical association	Medium	0.56	13
HMOX1	Physical association	Medium	0.56	25
HMOX2	Physical association	Medium	0.56	44
IGFBP5	Physical association	Medium	0.56	63
INSIG2	Physical association	Medium	0.56	34
JAGN1	Physical association	Medium	0.56	102
KIR2DL3	Physical association	Medium	0.56	54
LHFPL5	Physical association	Medium	0.56	108
LPAR3	Physical association	Medium	0.56	46
LRP10	Physical association	Medium	0.56	21
MAL	Physical association	Medium	0.56	68
MARCHF2	Physical association	Medium	0.56	23
MIP	Physical association	Medium	0.56	35
MMD	Physical association	Medium	0.56	16
MS4A1	Physical association	Medium	0.56	27
MS4A13	Physical association	Medium	0.56	52
MYADM	Physical association	Medium	0.56	9
MYADML2	Physical association	Medium	0.56	10
NAPB	Physical association	Medium	0.56	28
NAT8	Physical association	Medium	0.56	25
NCR3	Physical association	Medium	0.56	3
NINJ2	Physical association	Medium	0.56	63
NRM	Physical association	Medium	0.56	50
NXPE3	Physical association	Medium	0.56	4
OLFM4	Physical association	Medium	0.56	24
ORMDL3	Physical association	Medium	0.56	23
OTOR	Physical association	Medium	0.56	1
PAQR7	Physical association	Medium	0.56	4
PGLYRP3	Physical association	Medium	0.56	11
PLN	Physical association	Medium	0.56	44
PLP2	Physical association	Medium	0.56	58
PLPP4	Physical association	Medium	0.56	29
PLPP6	Physical association	Medium	0.56	44
PMP22	Physical association	Medium	0.56	52
PNLIPRP1	Physical association	Medium	0.56	31
RHAG	Physical association	Medium	0.56	4
RPRM	Physical association	Medium	0.56	66
RTP2	Physical association	Medium	0.56	63
RUSF1	Physical association	Medium	0.56	49
S100A2	Physical association	Medium	0.56	13
SCARF1	Physical association	Medium	0.56	18
SCGB1D1	Physical association	Medium	0.56	5
SCRG1	Physical association	Medium	0.56	4
SEC22A	Physical association	Medium	0.56	88
SEC22B	Physical association	Medium	0.56	45
SEC61G	Physical association	Medium	0.56	8
SELENOK	Physical association	Medium	0.56	24
SERP1	Physical association	Medium	0.56	37
SFTPC	Physical association	Medium	0.56	26
SLC13A3	Physical association	Medium	0.56	9
SLC1A1	Physical association	Medium	0.56	8
SLC30A8	Physical association	Medium	0.56	66
SLC35A1	Physical association	Medium	0.56	27
SLC35A4	Physical association	Medium	0.56	23
SLC35B4	Physical association	Medium	0.56	25
SLC35E3	Physical association	Medium	0.56	22
SLC35G2	Physical association	Medium	0.56	4
SLC38A7	Physical association	Medium	0.56	43
SLC52A2	Physical association	Medium	0.56	2
SLC7A14	Physical association	Medium	0.56	31
SMCO4	Physical association	Medium	0.56	51
SMIM1	Physical association	Medium	0.56	48
SNORC	Physical association	Medium	0.56	20
STATH	Physical association	Medium	0.56	21
STX1B	Physical association	Medium	0.56	21
STX3	Physical association	Medium	0.56	33
STX5	Physical association	Medium	0.56	26
STX8	Physical association	Medium	0.56	58
TECR	Physical association	Medium	0.56	22
TEX264	Physical association	Medium	0.56	23
TFRC	Physical association	Medium	0.56	23
THBD	Physical association	Medium	0.56	19
THSD7B	Physical association	Medium	0.56	23
TM6SF2	Physical association	Medium	0.56	8
TMBIM6	Physical association	Medium	0.56	55
TMEM100	Physical association	Medium	0.56	32
TMEM107	Physical association	Medium	0.56	38
TMEM11	Physical association	Medium	0.56	40
TMEM120A	Physical association	Medium	0.56	21
TMEM140	Physical association	Medium	0.56	44
TMEM141	Physical association	Medium	0.56	3
TMEM14B	Physical association	Medium	0.56	193
TMEM14C	Physical association	Medium	0.56	35
TMEM203	Physical association	Medium	0.56	34
TMEM208	Physical association	Medium	0.56	18
TMEM218	Physical association	Medium	0.56	61
TMEM222	Physical association	Medium	0.56	30
TMEM229B	Physical association	Medium	0.56	34
TMEM236	Physical association	Medium	0.56	4
TMEM243	Physical association	Medium	0.56	37
TMEM254	Physical association	Medium	0.56	35
TMEM42	Physical association	Medium	0.56	41
TMEM43	Physical association	Medium	0.56	13
TMEM47	Physical association	Medium	0.56	5
TMEM50B	Physical association	Medium	0.56	18
TMEM60	Physical association	Medium	0.56	86
TMEM65	Physical association	Medium	0.56	29
TMEM72	Physical association	Medium	0.56	9
TMEM79	Physical association	Medium	0.56	31
TMEM86A	Physical association	Medium	0.56	38
TMEM86B	Physical association	Medium	0.56	92
TMEM97	Physical association	Medium	0.56	49
TMPRSS4	Physical association	Medium	0.56	10
TMUB2	Physical association	Medium	0.56	15
TNF	Physical association	Medium	0.56	32
TNFRSF10C	Physical association	Medium	0.56	23
TRAF3IP3	Physical association	Medium	0.56	45
TRAM1L1	Physical association	Medium	0.56	20
TSPAN2	Physical association	Medium	0.56	34
TSPAN33	Physical association	Medium	0.56	23
TSPAN7	Physical association	Medium	0.56	3
TSPO	Physical association	Medium	0.56	13
TWSG1	Physical association	Medium	0.56	7
UBE2J1	Physical association	Medium	0.56	34
UBIAD1	Physical association	Medium	0.56	33
UNC50	Physical association	Medium	0.56	29
UPK1B	Physical association	Medium	0.56	41
VAMP3	Physical association	Medium	0.56	46
VAMP4	Physical association	Medium	0.56	35
VAMP5	Physical association	Medium	0.56	58
VKORC1	Physical association	Medium	0.56	12
VMP1	Physical association	Medium	0.56	6
WFDC2	Physical association	Medium	0.56	14
WFS1	Physical association	Medium	0.56	315
YIPF6	Physical association	Medium	0.56	72
ZFPL1	Physical association	Medium	0.56	54
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
FAM209A is not a metabolic protein