Protein interactions for TMEM14B - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TMEM14B
Gene descriptionⁱ Full gene name according to HGNC.	Transmembrane protein 14B
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Unknown function (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.19
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Not available
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Non-specific - Unknown function

Field

Cluster

Pathway

Number of interactions:

193

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
ABHD16A	Physical association	Medium	0.56	46
ABHD5	Physical association	Medium	0.56	16
ACSL5	Physical association	Medium	0.56	9
AGPAT3	Physical association	Medium	0.56	16
AGPAT4	Physical association	Medium	0.56	22
AGR3	Physical association	Medium	0.56	21
APOC4	Physical association	Medium	0.56	22
ARL6IP1	Physical association	Medium	0.56	60
ARL8B	Physical association	Medium	0.56	5
ARV1	Physical association	Medium	0.56	11
B4GALT7	Physical association	Medium	0.56	5
BIK	Physical association	Medium	0.56	79
BLCAP	Physical association	Medium	0.56	14
BMP10	Physical association	Medium	0.56	51
BTN2A2	Physical association	Medium	0.56	33
C14orf180	Physical association	Medium	0.56	38
C2CD2L	Physical association	Medium	0.56	31
CCL4	Physical association	Medium	0.56	16
CD79A	Physical association	Medium	0.56	144
CEPT1	Physical association	Medium	0.56	2
CFHR5	Physical association	Medium	0.56	15
CIDEB	Physical association	Medium	0.56	58
CLDN10	Physical association	Medium	0.56	7
CLDND2	Physical association	Medium	0.56	24
CMTM8	Physical association	Medium	0.56	3
CNIH2	Physical association	Medium	0.56	5
CNIH3	Physical association	Medium	0.56	23
CNIH4	Physical association	Medium	0.56	2
COMT	Physical association	Medium	0.56	53
CPLX4	Physical association	Medium	0.56	85
CREB3L1	Physical association	Medium	0.56	163
CYB561	Physical association	Medium	0.56	49
CYB5R3	Physical association	Medium	0.56	50
DEFB103A	Physical association	Medium	0.56	9
DEFB103B	Physical association	Medium	0.56	9
DGAT2L6	Physical association	Medium	0.56	37
DHRSX	Physical association	Medium	0.56	14
EBP	Physical association	Medium	0.56	159
EI24	Physical association	Medium	0.56	8
EMC6	Physical association	Medium	0.56	16
EPHX4	Physical association	Medium	0.56	1
ERGIC3	Physical association	Medium	0.56	186
EXTL1	Physical association	Medium	0.56	4
FA2H	Physical association	Medium	0.56	25
FAM209A	Physical association	Medium	0.56	199
FIS1	Physical association	Medium	0.56	22
FKBP8	Physical association	Medium	0.56	32
GDAP1	Physical association	Medium	0.56	29
GIMAP1	Physical association	Medium	0.56	40
GPR152	Physical association	Medium	0.56	163
GPX8	Physical association	Medium	0.56	135
GYPA	Physical association	Medium	0.56	24
GYPC	Physical association	Medium	0.56	11
HEXB	Physical association	Medium	0.56	25
HIBADH	Physical association	Medium	0.56	31
HIGD1C	Physical association	Medium	0.56	11
HMOX1	Physical association	Medium	0.56	25
HMOX2	Physical association	Medium	0.56	44
HSD17B11	Physical association	Medium	0.56	54
HSD3B1	Physical association	Medium	0.56	8
IER3IP1	Physical association	Medium	0.56	34
IFITM3	Physical association	Medium	0.56	22
INSIG2	Physical association	Medium	0.56	34
ITGAM	Physical association	Medium	0.56	34
JAGN1	Physical association	Medium	0.56	102
KCNA1	Physical association	Medium	0.56	13
KCNK1	Physical association	Medium	0.56	8
LEPROTL1	Physical association	Medium	0.56	68
LPAR3	Physical association	Medium	0.56	46
MAL2	Physical association	Medium	0.56	37
MARCHF5	Physical association	Medium	0.56	25
MFSD5	Physical association	Medium	0.56	46
MGAM	Physical association	Medium	0.56	5
MS4A13	Physical association	Medium	0.56	52
MS4A4A	Physical association	Medium	0.56	12
NAT8	Physical association	Medium	0.56	25
NDUFA3	Physical association	Medium	0.56	14
NEU1	Physical association	Medium	0.56	16
NINJ1	Physical association	Medium	0.56	16
NINJ2	Physical association	Medium	0.56	63
NIPAL3	Physical association	Medium	0.56	8
ORMDL1	Physical association	Medium	0.56	31
OTULINL	Physical association	Medium	0.56	11
PAGE1	Physical association	Medium	0.56	12
PDPN	Physical association	Medium	0.56	1
PDZK1IP1	Physical association	Medium	0.56	71
PEX11G	Physical association	Medium	0.56	5
PIGF	Physical association	Medium	0.56	8
PLLP	Physical association	Medium	0.56	33
PLP2	Physical association	Medium	0.56	58
PMP22	Physical association	Medium	0.56	52
PNLIPRP1	Physical association	Medium	0.56	31
PRAF2	Physical association	Medium	0.56	26
PTPMT1	Physical association	Medium	0.56	25
RABAC1	Physical association	Medium	0.56	48
RHOT2	Physical association	Medium	0.56	4
SAR1B	Physical association	Medium	0.56	2
SCAMP5	Physical association	Medium	0.56	15
SCN3B	Physical association	Medium	0.56	93
SCRG1	Physical association	Medium	0.56	4
SERF1A	Physical association	Medium	0.56	11
SERF1B	Physical association	Medium	0.56	11
SERP1	Physical association	Medium	0.56	37
SERP2	Physical association	Medium	0.56	42
SFT2D1	Physical association	Medium	0.56	27
SFT2D2	Physical association	Medium	0.56	24
SFXN1	Physical association	Medium	0.56	14
SFXN2	Physical association	Medium	0.56	5
SFXN3	Physical association	Medium	0.56	16
SLC16A10	Physical association	Medium	0.56	3
SLC16A13	Physical association	Medium	0.56	16
SLC19A3	Physical association	Medium	0.56	9
SLC2A6	Physical association	Medium	0.56	1
SLC30A3	Physical association	Medium	0.56	22
SLC30A8	Physical association	Medium	0.56	66
SLC35A4	Physical association	Medium	0.56	23
SLC35E3	Physical association	Medium	0.56	22
SLC35E4	Physical association	Medium	0.56	12
SLC35F1	Physical association	Medium	0.56	5
SLC35F6	Physical association	Medium	0.56	8
SLC35G1	Physical association	Medium	0.56	4
SLC39A2	Physical association	Medium	0.56	45
SLC39A7	Physical association	Medium	0.56	24
SLC48A1	Physical association	Medium	0.56	6
SLC7A8	Physical association	Medium	0.56	25
SMAGP	Physical association	Medium	0.56	35
SMPD2	Physical association	Medium	0.56	11
SQLE	Physical association	Medium	0.56	3
STOM	Physical association	Medium	0.56	120
STX12	Physical association	Medium	0.56	33
STX3	Physical association	Medium	0.56	33
STX6	Physical association	Medium	0.56	24
STX8	Physical association	Medium	0.56	58
SUCNR1	Physical association	Medium	0.56	2
SYNJ2BP	Physical association	Medium	0.56	22
TAP1	Physical association	Medium	0.56	17
TAS2R19	Physical association	Medium	0.56	6
TBC1D20	Physical association	Medium	0.56	4
TEX44	Physical association	Medium	0.56	11
THBD	Physical association	Medium	0.56	19
TIMM22	Physical association	Medium	0.56	3
TIMM23	Physical association	Medium	0.56	18
TIMMDC1	Physical association	Medium	0.56	53
TLCD1	Physical association	Medium	0.56	7
TM4SF4	Physical association	Medium	0.56	19
TMEM11	Physical association	Medium	0.56	40
TMEM120A	Physical association	Medium	0.56	21
TMEM120B	Physical association	Medium	0.56	46
TMEM121	Physical association	Medium	0.56	12
TMEM147	Physical association	Medium	0.56	44
TMEM14A	Physical association	Medium	0.56	21
TMEM14C	Physical association	Medium	0.56	35
TMEM187	Physical association	Medium	0.56	13
TMEM19	Physical association	Medium	0.56	34
TMEM199	Physical association	Medium	0.56	15
TMEM203	Physical association	Medium	0.56	34
TMEM220	Physical association	Medium	0.56	2
TMEM222	Physical association	Medium	0.56	30
TMEM229B	Physical association	Medium	0.56	34
TMEM243	Physical association	Medium	0.56	37
TMEM254	Physical association	Medium	0.56	35
TMEM255B	Physical association	Medium	0.56	5
TMEM267	Physical association	Medium	0.56	6
TMEM42	Physical association	Medium	0.56	41
TMEM50A	Physical association	Medium	0.56	9
TMEM50B	Physical association	Medium	0.56	18
TMEM51	Physical association	Medium	0.56	32
TMEM60	Physical association	Medium	0.56	86
TMEM69	Physical association	Medium	0.56	2
TMEM97	Physical association	Medium	0.56	49
TMUB1	Physical association	Medium	0.56	7
TMX2	Physical association	Medium	0.56	131
TOMM6	Physical association	Medium	0.56	9
TSPAN2	Physical association	Medium	0.56	34
TSPO	Physical association	Medium	0.56	13
TVP23B	Physical association	Medium	0.56	17
UBE2J1	Physical association	Medium	0.56	34
UBE2J2	Physical association	Medium	0.56	7
UBIAD1	Physical association	Medium	0.56	33
UBXN8	Physical association	Medium	0.56	7
UNC50	Physical association	Medium	0.56	29
VAMP5	Physical association	Medium	0.56	58
VRK2	Physical association	Medium	0.56	8
VTI1B	Physical association	Medium	0.56	26
YIF1A	Physical association	Medium	0.56	66
YIPF1	Physical association	Medium	0.56	30
YIPF2	Physical association	Medium	0.56	19
YIPF4	Physical association	Medium	0.56	28
YIPF6	Physical association	Medium	0.56	72
ZDHHC11	Physical association	Medium	0.56	1
ZDHHC22	Physical association	Medium	0.56	12
ZDHHC24	Physical association	Medium	0.56	17
ZFPL1	Physical association	Medium	0.56	54
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
TMEM14B is not a metabolic protein