Protein interactions for CPLX4 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CPLX4
Gene descriptionⁱ Full gene name according to HGNC.	Complexin 4
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Retina - Visual perception (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enriched (retina)
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.98
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Not available
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Retina - Visual perception

Field

Cluster

Pathway

Number of interactions:

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
ADIPOQ	Physical association	Medium	0.56	46
AOC3	Physical association	Medium	0.56	10
APOD	Physical association	Medium	0.56	38
AQP1	Physical association	Medium	0.56	106
AQP9	Physical association	Medium	0.56	18
ASGR1	Physical association	Medium	0.56	27
ATP6V0C	Physical association	Medium	0.56	47
BNIP2	Physical association	Medium	0.56	37
C14orf180	Physical association	Medium	0.56	38
C3orf52	Physical association	Medium	0.56	57
C5	Physical association	Medium	0.56	17
CACNG1	Physical association	Medium	0.56	15
CCL4L2	Physical association	Medium	0.56	31
CD81	Physical association	Medium	0.56	22
CDIPT	Physical association	Medium	0.56	47
CDS2	Physical association	Medium	0.56	29
CLDND2	Physical association	Medium	0.56	24
CLEC4G	Physical association	Medium	0.56	9
CLN6	Physical association	Medium	0.56	21
CNIH1	Physical association	Medium	0.56	21
CTXN3	Physical association	Medium	0.56	51
CYB5B	Physical association	Medium	0.56	37
CYBC1	Physical association	Medium	0.56	51
CYP4F2	Physical association	Medium	0.56	33
DEFB127	Physical association	Medium	0.56	12
EMD	Physical association	Medium	0.56	72
GAD2	Physical association	Medium	0.56	36
GIMAP1	Physical association	Medium	0.56	40
GRM2	Physical association	Medium	0.56	20
HACD1	Physical association	Medium	0.56	4
HHATL	Physical association	Medium	0.56	13
HMOX1	Physical association	Medium	0.56	25
INSIG2	Physical association	Medium	0.56	34
LPAR3	Physical association	Medium	0.56	46
MAL	Physical association	Medium	0.56	68
MALL	Physical association	Medium	0.56	51
MAN2B2	Physical association	Medium	0.56	9
MGAM	Physical association	Medium	0.56	5
NINJ2	Physical association	Medium	0.56	63
NRM	Physical association	Medium	0.56	50
ORMDL1	Physical association	Medium	0.56	31
PLN	Physical association	Medium	0.56	44
PLP2	Physical association	Medium	0.56	58
PLPP4	Physical association	Medium	0.56	29
PNLIPRP1	Physical association	Medium	0.56	31
PTPN9	Physical association	Medium	0.56	39
RTP2	Physical association	Medium	0.56	63
SEC22B	Physical association	Medium	0.56	45
SELENOK	Physical association	Medium	0.56	24
SFTPC	Physical association	Medium	0.56	26
SLC30A2	Physical association	Medium	0.56	55
SLC30A8	Physical association	Medium	0.56	66
SLC35A1	Physical association	Medium	0.56	27
SLC35A4	Physical association	Medium	0.56	23
SLC35B4	Physical association	Medium	0.56	25
SLC38A7	Physical association	Medium	0.56	43
SLC39A9	Physical association	Medium	0.56	30
SMCO4	Physical association	Medium	0.56	51
STX3	Physical association	Medium	0.56	33
STX8	Physical association	Medium	0.56	58
SYNJ2BP	Physical association	Medium	0.56	22
TF	Physical association	Medium	0.56	20
TMEM120B	Physical association	Medium	0.56	46
TMEM14A	Physical association	Medium	0.56	21
TMEM14B	Physical association	Medium	0.56	193
TMEM19	Physical association	Medium	0.56	34
TMEM203	Physical association	Medium	0.56	34
TMEM218	Physical association	Medium	0.56	61
TMEM229B	Physical association	Medium	0.56	34
TMEM243	Physical association	Medium	0.56	37
TMEM254	Physical association	Medium	0.56	35
TMEM267	Physical association	Medium	0.56	6
TMEM60	Physical association	Medium	0.56	86
TMEM79	Physical association	Medium	0.56	31
TMEM86A	Physical association	Medium	0.56	38
TMEM97	Physical association	Medium	0.56	49
TRAF3IP3	Physical association	Medium	0.56	45
TSPO2	Physical association	Medium	0.56	49
UBIAD1	Physical association	Medium	0.56	33
VAMP4	Physical association	Medium	0.56	35
VAMP5	Physical association	Medium	0.56	58
VKORC1	Physical association	Medium	0.56	12
WFDC2	Physical association	Medium	0.56	14
YIPF6	Physical association	Medium	0.56	72
ZFPL1	Physical association	Medium	0.56	54
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
CPLX4 is not a metabolic protein