Protein interactions for GPR152 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GPR152
Gene descriptionⁱ Full gene name according to HGNC.	G protein-coupled receptor 152
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	G-protein coupled receptors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Not detected - no cluster assigned
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Not detected
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	Not detected
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Not detected
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Not available
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria

Field

Cluster

Pathway

Number of interactions:

163

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
ABCG4	Physical association	Medium	0.56	5
ABHD16A	Physical association	Medium	0.56	46
ACSF2	Physical association	Medium	0.56	17
ADIPOQ	Physical association	Medium	0.56	46
AQP10	Physical association	Medium	0.56	17
AQP3	Physical association	Medium	0.56	23
AQP6	Physical association	Medium	0.56	264
ARL6IP1	Physical association	Medium	0.56	60
ARV1	Physical association	Medium	0.56	11
ATP6V0C	Physical association	Medium	0.56	47
B3GNT7	Physical association	Medium	0.56	1
BET1	Physical association	Medium	0.56	41
BMP10	Physical association	Medium	0.56	51
BNIP2	Physical association	Medium	0.56	37
BNIP3	Physical association	Medium	0.56	49
C14orf180	Physical association	Medium	0.56	38
C1QL4	Physical association	Medium	0.56	16
C8A	Physical association	Medium	0.56	6
CCDC167	Physical association	Medium	0.56	32
CCL4	Physical association	Medium	0.56	16
CCL4L2	Physical association	Medium	0.56	31
CD53	Physical association	Medium	0.56	57
CD72	Physical association	Medium	0.56	13
CD81	Physical association	Medium	0.56	22
CDIPT	Physical association	Medium	0.56	47
CDS2	Physical association	Medium	0.56	29
CGRRF1	Physical association	Medium	0.56	26
CLDND2	Physical association	Medium	0.56	24
CLEC17A	Physical association	Medium	0.56	19
CLEC1A	Physical association	Medium	0.56	13
CNIH1	Physical association	Medium	0.56	21
COMT	Physical association	Medium	0.56	53
CSGALNACT2	Physical association	Medium	0.56	16
CTXN3	Physical association	Medium	0.56	51
CYB561	Physical association	Medium	0.56	49
CYB561A3	Physical association	Medium	0.56	21
CYB5B	Physical association	Medium	0.56	37
CYB5R3	Physical association	Medium	0.56	50
CYBC1	Physical association	Medium	0.56	51
DEFB108B	Physical association	Medium	0.56	3
DGAT2L6	Physical association	Medium	0.56	37
EBP	Physical association	Medium	0.56	159
EDDM3B	Physical association	Medium	0.56	17
EFNA5	Physical association	Medium	0.56	28
EMD	Physical association	Medium	0.56	72
ERG28	Physical association	Medium	0.56	48
FA2H	Physical association	Medium	0.56	25
FAM20B	Physical association	Medium	0.56	8
FAXDC2	Physical association	Medium	0.56	28
FDFT1	Physical association	Medium	0.56	12
FUNDC2	Physical association	Medium	0.56	22
GAST	Physical association	Medium	0.56	18
GJB2	Physical association	Medium	0.56	33
GOLT1A	Physical association	Medium	0.56	23
GOLT1B	Physical association	Medium	0.56	8
GOSR2	Physical association	Medium	0.56	45
GPR151	Physical association	Medium	0.56	35
GPR37L1	Physical association	Medium	0.56	49
HHATL	Physical association	Medium	0.56	13
HMOX1	Physical association	Medium	0.56	25
HMOX2	Physical association	Medium	0.56	44
IFNA8	Physical association	Medium	0.56	1
IGFBP5	Physical association	Medium	0.56	63
INSIG2	Physical association	Medium	0.56	34
JAGN1	Physical association	Medium	0.56	102
KCNA1	Physical association	Medium	0.56	13
KCNN4	Physical association	Medium	0.56	7
LAMB1	Physical association	Medium	0.56	3
LEPROTL1	Physical association	Medium	0.56	68
LHFPL2	Physical association	Medium	0.56	9
LHFPL5	Physical association	Medium	0.56	108
LTC4S	Physical association	Medium	0.56	8
MAL	Physical association	Medium	0.56	68
MAL2	Physical association	Medium	0.56	37
MFSD5	Physical association	Medium	0.56	46
MFSD6	Physical association	Medium	0.56	31
MGST3	Physical association	Medium	0.56	79
MMD	Physical association	Medium	0.56	16
MOSPD3	Physical association	Medium	0.56	13
MS4A13	Physical association	Medium	0.56	52
MYADML2	Physical association	Medium	0.56	10
NAT8	Physical association	Medium	0.56	25
NDUFB11	Physical association	Medium	0.56	9
NEU1	Physical association	Medium	0.56	16
NINJ2	Physical association	Medium	0.56	63
NIPAL4	Physical association	Medium	0.56	15
ORMDL1	Physical association	Medium	0.56	31
ORMDL3	Physical association	Medium	0.56	23
PEX16	Physical association	Medium	0.56	23
PIGF	Physical association	Medium	0.56	8
PIN1	Physical association	Medium	0.56	112
PLN	Physical association	Medium	0.56	44
PNLIPRP1	Physical association	Medium	0.56	31
PRAF2	Physical association	Medium	0.56	26
PROM2	Physical association	Medium	0.56	2
RABAC1	Physical association	Medium	0.56	48
RBFA	Physical association	Medium	0.56	20
ROBO2	Physical association	Medium	0.56	1
RTP2	Physical association	Medium	0.56	63
SACM1L	Physical association	Medium	0.56	26
SCAMP4	Physical association	Medium	0.56	16
SCD	Physical association	Medium	0.56	36
SEC22B	Physical association	Medium	0.56	45
SERF1A	Physical association	Medium	0.56	11
SERF1B	Physical association	Medium	0.56	11
SERP2	Physical association	Medium	0.56	42
SFT2D2	Physical association	Medium	0.56	24
SFTPC	Physical association	Medium	0.56	26
SLC10A1	Physical association	Medium	0.56	76
SLC13A4	Physical association	Medium	0.56	22
SLC30A3	Physical association	Medium	0.56	22
SLC35A4	Physical association	Medium	0.56	23
SLC35B1	Physical association	Medium	0.56	13
SLC35B4	Physical association	Medium	0.56	25
SLC35F6	Physical association	Medium	0.56	8
SLC38A1	Physical association	Medium	0.56	26
SLC38A7	Physical association	Medium	0.56	43
SLC39A2	Physical association	Medium	0.56	45
SLC41A1	Physical association	Medium	0.56	26
SLC66A2	Physical association	Medium	0.56	19
SLC7A1	Physical association	Medium	0.56	47
SMCO4	Physical association	Medium	0.56	51
STATH	Physical association	Medium	0.56	21
STX1B	Physical association	Medium	0.56	21
STX3	Physical association	Medium	0.56	33
STX4	Physical association	Medium	0.56	37
STX5	Physical association	Medium	0.56	26
STX8	Physical association	Medium	0.56	58
TAP1	Physical association	Medium	0.56	17
TEX264	Physical association	Medium	0.56	23
TFRC	Physical association	Medium	0.56	23
THSD7B	Physical association	Medium	0.56	23
TIMMDC1	Physical association	Medium	0.56	53
TM4SF19	Physical association	Medium	0.56	32
TMEM100	Physical association	Medium	0.56	32
TMEM120B	Physical association	Medium	0.56	46
TMEM140	Physical association	Medium	0.56	44
TMEM14B	Physical association	Medium	0.56	193
TMEM14C	Physical association	Medium	0.56	35
TMEM208	Physical association	Medium	0.56	18
TMEM218	Physical association	Medium	0.56	61
TMEM236	Physical association	Medium	0.56	4
TMEM243	Physical association	Medium	0.56	37
TMEM254	Physical association	Medium	0.56	35
TMEM42	Physical association	Medium	0.56	41
TMEM50B	Physical association	Medium	0.56	18
TMEM54	Physical association	Medium	0.56	19
TMEM60	Physical association	Medium	0.56	86
TMEM97	Physical association	Medium	0.56	49
TMPPE	Physical association	Medium	0.56	30
TNFRSF10C	Physical association	Medium	0.56	23
TSPAN33	Physical association	Medium	0.56	23
TSPAN7	Physical association	Medium	0.56	3
TSPO2	Physical association	Medium	0.56	49
UBIAD1	Physical association	Medium	0.56	33
UNC50	Physical association	Medium	0.56	29
VAMP4	Physical association	Medium	0.56	35
VAMP5	Physical association	Medium	0.56	58
VKORC1	Physical association	Medium	0.56	12
YIPF1	Physical association	Medium	0.56	30
YIPF4	Physical association	Medium	0.56	28
YIPF6	Physical association	Medium	0.56	72
ZDHHC15	Physical association	Medium	0.56	47
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
GPR152 is not a metabolic protein