Protein interactions for CD79A - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CD79A
Gene descriptionⁱ Full gene name according to HGNC.	CD79a molecule
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Cancer-related genes CD markers Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Lymphoid tissue - Cytokine signaling (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Group enriched (intestine, lymphoid tissue)
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.75
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Not available
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Lymphoid tissue - Cytokine signaling

Field

Cluster

Pathway

Number of interactions:

144

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
FATE1	Physical association	High	0.72	78
ADIPOQ	Physical association	Medium	0.56	46
ALG10	Physical association	Medium	0.56	5
ALG10B	Physical association	Medium	0.56	2
ALG3	Physical association	Medium	0.56	10
APOD	Physical association	Medium	0.56	38
AQP1	Physical association	Medium	0.56	106
AQP3	Physical association	Medium	0.56	23
ATP6V0C	Physical association	Medium	0.56	47
BCL2L2	Physical association	Medium	0.56	45
BCL2L2-PABPN1	Physical association	Medium	0.56	45
BET1	Physical association	Medium	0.56	41
BTN2A2	Physical association	Medium	0.56	33
C14orf180	Physical association	Medium	0.56	38
C2CD2L	Physical association	Medium	0.56	31
CCDC167	Physical association	Medium	0.56	32
CDIPT	Physical association	Medium	0.56	47
CLDN1	Physical association	Medium	0.56	6
CLN6	Physical association	Medium	0.56	21
CMTM7	Physical association	Medium	0.56	39
CNIH1	Physical association	Medium	0.56	21
CNIH3	Physical association	Medium	0.56	23
CTXN3	Physical association	Medium	0.56	51
CYB561	Physical association	Medium	0.56	49
CYB561A3	Physical association	Medium	0.56	21
CYB561D2	Physical association	Medium	0.56	16
CYB5B	Physical association	Medium	0.56	37
DEFB127	Physical association	Medium	0.56	12
DOLK	Physical association	Medium	0.56	19
EDDM3B	Physical association	Medium	0.56	17
EMC6	Physical association	Medium	0.56	16
EMP1	Physical association	Medium	0.56	55
EMP3	Physical association	Medium	0.56	45
FA2H	Physical association	Medium	0.56	25
FAXDC2	Physical association	Medium	0.56	28
FDFT1	Physical association	Medium	0.56	12
FFAR3	Physical association	Medium	0.56	12
FKBP8	Physical association	Medium	0.56	32
FUNDC2	Physical association	Medium	0.56	22
GALNT15	Physical association	Medium	0.56	13
GIMAP1	Physical association	Medium	0.56	40
GJB1	Physical association	Medium	0.56	37
GPR42	Physical association	Medium	0.56	88
HACD4	Physical association	Medium	0.56	1
HMOX1	Physical association	Medium	0.56	25
HMOX2	Physical association	Medium	0.56	44
IER3	Physical association	Medium	0.56	11
INSIG2	Physical association	Medium	0.56	34
ITGAM	Physical association	Medium	0.56	34
JAGN1	Physical association	Medium	0.56	102
LAMB1	Physical association	Medium	0.56	3
LEPROTL1	Physical association	Medium	0.56	68
LHFPL5	Physical association	Medium	0.56	108
LPAR3	Physical association	Medium	0.56	46
LTC4S	Physical association	Medium	0.56	8
MALL	Physical association	Medium	0.56	51
MARCHF2	Physical association	Medium	0.56	23
MFSD5	Physical association	Medium	0.56	46
MFSD6	Physical association	Medium	0.56	31
MOSPD3	Physical association	Medium	0.56	13
MS4A13	Physical association	Medium	0.56	52
MYADM	Physical association	Medium	0.56	9
MYADML2	Physical association	Medium	0.56	10
NAT8	Physical association	Medium	0.56	25
NEU1	Physical association	Medium	0.56	16
NINJ2	Physical association	Medium	0.56	63
NIPAL3	Physical association	Medium	0.56	8
NKG7	Physical association	Medium	0.56	39
ORMDL2	Physical association	Medium	0.56	18
OTOP2	Physical association	Medium	0.56	4
PLP2	Physical association	Medium	0.56	58
PLPP6	Physical association	Medium	0.56	44
PLPPR2	Physical association	Medium	0.56	20
PNLIPRP1	Physical association	Medium	0.56	31
PRAF2	Physical association	Medium	0.56	26
RHO	Physical association	Medium	0.56	2
RTP2	Physical association	Medium	0.56	63
SACM1L	Physical association	Medium	0.56	26
SEC22B	Physical association	Medium	0.56	45
SERP1	Physical association	Medium	0.56	37
SFTPC	Physical association	Medium	0.56	26
SLC13A4	Physical association	Medium	0.56	22
SLC13A5	Physical association	Medium	0.56	16
SLC16A12	Physical association	Medium	0.56	3
SLC16A13	Physical association	Medium	0.56	16
SLC30A2	Physical association	Medium	0.56	55
SLC35B1	Physical association	Medium	0.56	13
SLC35B4	Physical association	Medium	0.56	25
SLC38A1	Physical association	Medium	0.56	26
SLC39A2	Physical association	Medium	0.56	45
SLC39A9	Physical association	Medium	0.56	30
SLC41A1	Physical association	Medium	0.56	26
SLC41A2	Physical association	Medium	0.56	28
SLC66A2	Physical association	Medium	0.56	19
SLC6A12	Physical association	Medium	0.56	3
SLC7A1	Physical association	Medium	0.56	47
SMCO4	Physical association	Medium	0.56	51
SMIM3	Physical association	Medium	0.56	44
STRIT1	Physical association	Medium	0.56	32
STX12	Physical association	Medium	0.56	33
STX3	Physical association	Medium	0.56	33
STX8	Physical association	Medium	0.56	58
SYNJ2BP	Physical association	Medium	0.56	22
TECR	Physical association	Medium	0.56	22
THBD	Physical association	Medium	0.56	19
TM4SF19	Physical association	Medium	0.56	32
TM4SF4	Physical association	Medium	0.56	19
TMBIM6	Physical association	Medium	0.56	55
TMEM107	Physical association	Medium	0.56	38
TMEM11	Physical association	Medium	0.56	40
TMEM140	Physical association	Medium	0.56	44
TMEM147	Physical association	Medium	0.56	44
TMEM14B	Physical association	Medium	0.56	193
TMEM176A	Physical association	Medium	0.56	12
TMEM187	Physical association	Medium	0.56	13
TMEM19	Physical association	Medium	0.56	34
TMEM218	Physical association	Medium	0.56	61
TMEM222	Physical association	Medium	0.56	30
TMEM229B	Physical association	Medium	0.56	34
TMEM243	Physical association	Medium	0.56	37
TMEM254	Physical association	Medium	0.56	35
TMEM262	Physical association	Medium	0.56	12
TMEM42	Physical association	Medium	0.56	41
TMEM86A	Physical association	Medium	0.56	38
TMEM86B	Physical association	Medium	0.56	92
TMPPE	Physical association	Medium	0.56	30
TNFRSF10C	Physical association	Medium	0.56	23
TRAM1L1	Physical association	Medium	0.56	20
TSPAN2	Physical association	Medium	0.56	34
TSPO2	Physical association	Medium	0.56	49
UBE2J1	Physical association	Medium	0.56	34
UBIAD1	Physical association	Medium	0.56	33
UNC93B1	Physical association	Medium	0.56	24
VAMP3	Physical association	Medium	0.56	46
VAPA	Physical association	Medium	0.56	37
VAPB	Physical association	Medium	0.56	33
VTI1B	Physical association	Medium	0.56	26
WFDC2	Physical association	Medium	0.56	14
WFS1	Physical association	Medium	0.56	315
YIF1A	Physical association	Medium	0.56	66
YIPF4	Physical association	Medium	0.56	28
YIPF6	Physical association	Medium	0.56	72
ZDHHC15	Physical association	Medium	0.56	47
ZDHHC22	Physical association	Medium	0.56	12
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
CD79A is not a metabolic protein