Protein interactions for GPX8 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GPX8
Gene descriptionⁱ Full gene name according to HGNC.	Glutathione peroxidase 8 (putative)
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Connective tissue - ECM organization (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.40
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Plasma membrane, Cytosol In addition localized to the Actin filaments
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Connective tissue - ECM organization

Field

Cluster

Pathway

Number of interactions:

135

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
ALG8	Physical association	Medium	0.56	8
APOC3	Physical association	Medium	0.56	3
APOD	Physical association	Medium	0.56	38
AQP1	Physical association	Medium	0.56	106
AQP2	Physical association	Medium	0.56	33
AQP3	Physical association	Medium	0.56	23
ASGR1	Physical association	Medium	0.56	27
BCL2L2	Physical association	Medium	0.56	45
BCL2L2-PABPN1	Physical association	Medium	0.56	45
BET1	Physical association	Medium	0.56	41
BIK	Physical association	Medium	0.56	79
BMP10	Physical association	Medium	0.56	51
BNIP2	Physical association	Medium	0.56	37
BTN2A2	Physical association	Medium	0.56	33
C14orf180	Physical association	Medium	0.56	38
CACNG1	Physical association	Medium	0.56	15
CD302	Physical association	Medium	0.56	9
CD53	Physical association	Medium	0.56	57
CD81	Physical association	Medium	0.56	22
CDIPT	Physical association	Medium	0.56	47
CDS2	Physical association	Medium	0.56	29
CFHR5	Physical association	Medium	0.56	15
CHST1	Physical association	Medium	0.56	2
CLEC1A	Physical association	Medium	0.56	13
CLEC2A	Physical association	Medium	0.56	4
CNIH1	Physical association	Medium	0.56	21
CNIH3	Physical association	Medium	0.56	23
CORIN	Physical association	Medium	0.56	4
CYB561	Physical association	Medium	0.56	49
CYB561A3	Physical association	Medium	0.56	21
CYB561D2	Physical association	Medium	0.56	16
DNAJC30	Physical association	Medium	0.56	23
DOLK	Physical association	Medium	0.56	19
EDDM3B	Physical association	Medium	0.56	17
ERG28	Physical association	Medium	0.56	48
FA2H	Physical association	Medium	0.56	25
FAM3C	Physical association	Medium	0.56	45
FAXDC2	Physical association	Medium	0.56	28
GET3	Physical association	Medium	0.56	32
GOSR2	Physical association	Medium	0.56	45
GPR151	Physical association	Medium	0.56	35
GPR37L1	Physical association	Medium	0.56	49
GRINA	Physical association	Medium	0.56	6
GYPA	Physical association	Medium	0.56	24
HHATL	Physical association	Medium	0.56	13
HMOX2	Physical association	Medium	0.56	44
IGFBP5	Physical association	Medium	0.56	63
INSIG2	Physical association	Medium	0.56	34
KIR2DL3	Physical association	Medium	0.56	54
KLRG1	Physical association	Medium	0.56	9
LAPTM4B	Physical association	Medium	0.56	19
LEPROTL1	Physical association	Medium	0.56	68
LHFPL5	Physical association	Medium	0.56	108
LPAR3	Physical association	Medium	0.56	46
MAN2B2	Physical association	Medium	0.56	9
MARCHF2	Physical association	Medium	0.56	23
MARCHF5	Physical association	Medium	0.56	25
MFSD5	Physical association	Medium	0.56	46
MFSD6	Physical association	Medium	0.56	31
MGST2	Physical association	Medium	0.56	22
MGST3	Physical association	Medium	0.56	79
MIP	Physical association	Medium	0.56	35
MMD	Physical association	Medium	0.56	16
MYADML2	Physical association	Medium	0.56	10
NEU1	Physical association	Medium	0.56	16
NINJ1	Physical association	Medium	0.56	16
NIPAL3	Physical association	Medium	0.56	8
NKG7	Physical association	Medium	0.56	39
NRM	Physical association	Medium	0.56	50
OCLN	Physical association	Medium	0.56	5
PAEP	Physical association	Medium	0.56	12
PAQR5	Physical association	Medium	0.56	5
PAQR6	Physical association	Medium	0.56	3
PLLP	Physical association	Medium	0.56	33
PLN	Physical association	Medium	0.56	44
PLP2	Physical association	Medium	0.56	58
PLPP4	Physical association	Medium	0.56	29
PLPP6	Physical association	Medium	0.56	44
PNLIPRP1	Physical association	Medium	0.56	31
RBFA	Physical association	Medium	0.56	20
RND1	Physical association	Medium	0.56	5
RTP2	Physical association	Medium	0.56	63
SCARB2	Physical association	Medium	0.56	5
SCARF1	Physical association	Medium	0.56	18
SCD	Physical association	Medium	0.56	36
SEC22B	Physical association	Medium	0.56	45
SELENOK	Physical association	Medium	0.56	24
SERINC1	Physical association	Medium	0.56	5
SERP1	Physical association	Medium	0.56	37
SERTM1	Physical association	Medium	0.56	13
SFTPC	Physical association	Medium	0.56	26
SGMS2	Physical association	Medium	0.56	3
SLC13A3	Physical association	Medium	0.56	9
SLC30A3	Physical association	Medium	0.56	22
SLC34A3	Physical association	Medium	0.56	4
SLC35A1	Physical association	Medium	0.56	27
SLC35B4	Physical association	Medium	0.56	25
SLC41A2	Physical association	Medium	0.56	28
SMAGP	Physical association	Medium	0.56	35
SNORC	Physical association	Medium	0.56	20
STX3	Physical association	Medium	0.56	33
STX8	Physical association	Medium	0.56	58
TF	Physical association	Medium	0.56	20
THBD	Physical association	Medium	0.56	19
TIMMDC1	Physical association	Medium	0.56	53
TM4SF4	Physical association	Medium	0.56	19
TMBIM6	Physical association	Medium	0.56	55
TMEM107	Physical association	Medium	0.56	38
TMEM109	Physical association	Medium	0.56	13
TMEM120B	Physical association	Medium	0.56	46
TMEM14B	Physical association	Medium	0.56	193
TMEM19	Physical association	Medium	0.56	34
TMEM218	Physical association	Medium	0.56	61
TMEM229B	Physical association	Medium	0.56	34
TMEM243	Physical association	Medium	0.56	37
TMEM254	Physical association	Medium	0.56	35
TMEM42	Physical association	Medium	0.56	41
TMEM50B	Physical association	Medium	0.56	18
TMEM60	Physical association	Medium	0.56	86
TMEM86B	Physical association	Medium	0.56	92
TMEM97	Physical association	Medium	0.56	49
TMPRSS4	Physical association	Medium	0.56	10
TMUB2	Physical association	Medium	0.56	15
TRAM1L1	Physical association	Medium	0.56	20
TSPAN33	Physical association	Medium	0.56	23
UNC50	Physical association	Medium	0.56	29
UPK1B	Physical association	Medium	0.56	41
VAMP3	Physical association	Medium	0.56	46
VAMP4	Physical association	Medium	0.56	35
VAMP5	Physical association	Medium	0.56	58
VKORC1L1	Physical association	Medium	0.56	15
VTI1B	Physical association	Medium	0.56	26
YIF1A	Physical association	Medium	0.56	66
YIPF6	Physical association	Medium	0.56	72
ZDHHC22	Physical association	Medium	0.56	12
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene GPX8 is associated with 11 reactions in 3 different subsystems, and present in the compartments: Cytosol, Endoplasmic reticulum, Extracellular, Mitochondria, Peroxisome. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Arachidonic acid metabolism	Cytosol, Peroxisome, Endoplasmic reticulum, Extracellular, Nucleus, Mitochondria	108	87	7
Glutathione metabolism	Extracellular, Cytosol, Mitochondria	33	21	3
Linoleate metabolism	Cytosol, Endoplasmic reticulum	63	42	1